FOXO6_HUMAN
ID FOXO6_HUMAN Reviewed; 492 AA.
AC A8MYZ6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Forkhead box protein O6;
GN Name=FOXO6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- FUNCTION: Transcriptional activator. {ECO:0000250}.
CC -!- INTERACTION:
CC A8MYZ6; P41235: HNF4A; NbExp=2; IntAct=EBI-8531039, EBI-1049011;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00089}. Note=When phosphorylated,
CC translocated from nucleus to cytoplasm. High nuclear localization after
CC stimulation with growth factors (By similarity). {ECO:0000250}.
CC -!- PTM: Phosphorylation of Ser-184 is be important in regulating the
CC transacriptional activity. {ECO:0000250}.
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DR EMBL; AC093151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A8MYZ6; -.
DR SMR; A8MYZ6; -.
DR IntAct; A8MYZ6; 14.
DR MINT; A8MYZ6; -.
DR STRING; 9606.ENSP00000361672; -.
DR iPTMnet; A8MYZ6; -.
DR PhosphoSitePlus; A8MYZ6; -.
DR BioMuta; FOXO6; -.
DR jPOST; A8MYZ6; -.
DR MassIVE; A8MYZ6; -.
DR MaxQB; A8MYZ6; -.
DR PaxDb; A8MYZ6; -.
DR PeptideAtlas; A8MYZ6; -.
DR PRIDE; A8MYZ6; -.
DR ProteomicsDB; 2440; -.
DR Antibodypedia; 46860; 63 antibodies from 19 providers.
DR Ensembl; ENST00000641094.2; ENSP00000493184.1; ENSG00000204060.8.
DR UCSC; uc057fie.1; human.
DR GeneCards; FOXO6; -.
DR HGNC; HGNC:24814; FOXO6.
DR HPA; ENSG00000204060; Not detected.
DR MIM; 611457; gene.
DR neXtProt; NX_A8MYZ6; -.
DR OpenTargets; ENSG00000204060; -.
DR PharmGKB; PA162388893; -.
DR VEuPathDB; HostDB:ENSG00000204060; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000161401; -.
DR HOGENOM; CLU_023456_2_0_1; -.
DR InParanoid; A8MYZ6; -.
DR OMA; QPAMSLM; -.
DR PhylomeDB; A8MYZ6; -.
DR PathwayCommons; A8MYZ6; -.
DR Reactome; R-HSA-198693; AKT phosphorylates targets in the nucleus.
DR Reactome; R-HSA-5674400; Constitutive Signaling by AKT1 E17K in Cancer.
DR Reactome; R-HSA-9614399; Regulation of localization of FOXO transcription factors.
DR Reactome; R-HSA-9615017; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes.
DR SignaLink; A8MYZ6; -.
DR SIGNOR; A8MYZ6; -.
DR ChiTaRS; FOXO6; human.
DR Pharos; A8MYZ6; Tbio.
DR PRO; PR:A8MYZ6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A8MYZ6; protein.
DR Bgee; ENSG00000204060; Expressed in cortical plate and 89 other tissues.
DR Genevisible; A8MYZ6; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005737; C:cytoplasm; ISS:ParkinsonsUK-UCL.
DR GO; GO:0005634; C:nucleus; ISS:ParkinsonsUK-UCL.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:ParkinsonsUK-UCL.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0060999; P:positive regulation of dendritic spine development; ISS:ParkinsonsUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:ParkinsonsUK-UCL.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032067; FOXO-TAD.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16676; FOXO-TAD; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..492
FT /note="Forkhead box protein O6"
FT /id="PRO_0000317413"
FT DNA_BIND 88..182
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..492
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 184
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q70KY4"
SQ SEQUENCE 492 AA; 50595 MW; 85061867EDA1D656 CRC64;
MAAKLRAHQV DVDPDFAPQS RPRSCTWPLP QPDLAGDEDG ALGAGVAEGA EDCGPERRAT
APAMAPAPPL GAEVGPLRKA KSSRRNAWGN LSYADLITKA IESAPDKRLT LSQIYDWMVR
YVPYFKDKGD SNSSAGWKNS IRHNLSLHTR FIRVQNEGTG KSSWWMLNPE GGKTGKTPRR
RAVSMDNGAK FLRIKGKASK KKQLQAPERS PDDSSPSAPA PGPVPAAAKW AASPASHASD
DYEAWADFRG GGRPLLGEAA ELEDDEALEA LAPSSPLMYP SPASALSPAL GSRCPGELPR
LAELGGPLGL HGGGGAGLPE GLLDGAQDAY GPRPAPRPGP VLGAPGELAL AGAAAAYPGK
GAAPYAPPAP SRSALAHPIS LMTLPGEAGA AGLAPPGHAA AFGGPPGGLL LDALPGPYAA
AAAGPLGAAP DRFPADLDLD MFSGSLECDV ESIILNDFMD SDEMDFNFDS ALPPPPPGLA
GAPPPNQSWV PG
