FOXO6_MOUSE
ID FOXO6_MOUSE Reviewed; 559 AA.
AC Q70KY4;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Forkhead box protein O6;
GN Name=Foxo6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, PHOSPHORYLATION AT SER-184, AND
RP MUTAGENESIS OF THR-26 AND SER-184.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=12857750; DOI=10.1074/jbc.m302804200;
RA Jacobs F.M.J., van der Heide L.P., Wijchers P.J.E.C., Burbach J.P.H.,
RA Hoekman M.F.M., Smidt M.P.;
RT "FoxO6, a novel member of the FoxO class of transcription factors with
RT distinct shuttling dynamics.";
RL J. Biol. Chem. 278:35959-35967(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Transcriptional activator. {ECO:0000269|PubMed:12857750}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12857750}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:12857750}.
CC Note=When phosphorylated, translocated from nucleus to cytoplasm. High
CC nuclear localization after stimulation with growth factors.
CC -!- TISSUE SPECIFICITY: Expressed in brain in areas of the nucleus
CC accumbens, cingulate cortex, parts of the amygdala and in the
CC hippocampus. {ECO:0000269|PubMed:12857750}.
CC -!- DEVELOPMENTAL STAGE: Expressed in developing brain in a specific
CC temporal and spatial pattern. {ECO:0000269|PubMed:12857750}.
CC -!- PTM: Phosphorylation of Ser-184 is be important in regulating the
CC transacriptional activity. {ECO:0000269|PubMed:12857750}.
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DR EMBL; AJ571690; CAE00176.1; -; mRNA.
DR EMBL; AL626767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS18588.1; -.
DR RefSeq; NP_918949.1; NM_194060.1.
DR AlphaFoldDB; Q70KY4; -.
DR SMR; Q70KY4; -.
DR STRING; 10090.ENSMUSP00000099716; -.
DR iPTMnet; Q70KY4; -.
DR PhosphoSitePlus; Q70KY4; -.
DR MaxQB; Q70KY4; -.
DR PaxDb; Q70KY4; -.
DR PRIDE; Q70KY4; -.
DR ProteomicsDB; 271595; -.
DR Antibodypedia; 46860; 63 antibodies from 19 providers.
DR DNASU; 329934; -.
DR Ensembl; ENSMUST00000102656; ENSMUSP00000099716; ENSMUSG00000052135.
DR GeneID; 329934; -.
DR KEGG; mmu:329934; -.
DR UCSC; uc008unc.1; mouse.
DR CTD; 100132074; -.
DR MGI; MGI:2676586; Foxo6.
DR VEuPathDB; HostDB:ENSMUSG00000052135; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000161401; -.
DR HOGENOM; CLU_023456_1_0_1; -.
DR InParanoid; Q70KY4; -.
DR OMA; QPAMSLM; -.
DR OrthoDB; 1160384at2759; -.
DR PhylomeDB; Q70KY4; -.
DR TreeFam; TF315583; -.
DR Reactome; R-MMU-198693; AKT phosphorylates targets in the nucleus.
DR Reactome; R-MMU-9614399; Regulation of localization of FOXO transcription factors.
DR Reactome; R-MMU-9617828; FOXO-mediated transcription of cell cycle genes.
DR BioGRID-ORCS; 329934; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Foxo6; mouse.
DR PRO; PR:Q70KY4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q70KY4; protein.
DR Bgee; ENSMUSG00000052135; Expressed in cortical plate and 67 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:ParkinsonsUK-UCL.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007613; P:memory; IMP:ParkinsonsUK-UCL.
DR GO; GO:0060999; P:positive regulation of dendritic spine development; IMP:ParkinsonsUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:ParkinsonsUK-UCL.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032067; FOXO-TAD.
DR InterPro; IPR032068; FOXO_KIX-bd.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16676; FOXO-TAD; 1.
DR Pfam; PF16675; FOXO_KIX_bdg; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..559
FT /note="Forkhead box protein O6"
FT /id="PRO_0000317414"
FT DNA_BIND 88..182
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..559
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 184
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:12857750"
FT MUTAGEN 26
FT /note="T->A: No IGF1-induced increase in cytoplasmic
FT localization."
FT /evidence="ECO:0000269|PubMed:12857750"
FT MUTAGEN 184
FT /note="S->A: No IGF1-induced increase in cytoplasmic
FT localization. Increased transactivation activity."
FT /evidence="ECO:0000269|PubMed:12857750"
SQ SEQUENCE 559 AA; 57595 MW; A6FD814864572215 CRC64;
MAAKLRAHQV DVDPDFAPQS RPRSCTWPLP QPDLAGDEDG ALGAGVAEGS EDCGPERRAT
APAMAPAPPL GAEVGPLRKA KSSRRNAWGN LSYADLITKA IESAPDKRLT LSQIYDWMVR
YVPYFKDKGD SNSSAGWKNS IRHNLSLHTR FIRVQNEGTG KSSWWMLNPE GGKTGKTPRR
RAVSMDNGAK FLRIKGKASK KKQLHLPERS PDDSPPGAPV PGPLSASAKW AASPASHASD
DYEAWADFRG SRRPLLGEAA ELEDDEALEA LAPSSPLMYP SPASALSPAL GARCPGELPR
LAELGGPLGL HGGGVAGLPD ALLDGAQDAY GPRARAGTPS YFGSCKASAY GGGGGFGPPA
LGSLRRLPMQ TIQENKQASF VQAAAPFRPG ALPALLPPPP PAPRPGPLLG APGELALAGA
AAAYPGKGAA PYAPPAPSRS ALAHPISLMT LPGEAGAAGL APPAHAAAFG GPPGGLLLDA
LPGPYAAAAA GPLGAGPDRF PADLDLDMFS GSLECDVESI ILNDFMDSDE MDFNFDSALP
PPPPGLAGAP PPNQSWVPG
