FOXP1_CHICK
ID FOXP1_CHICK Reviewed; 686 AA.
AC Q58NQ4;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Forkhead box protein P1;
GN Name=FOXP1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16397219; DOI=10.1158/0008-5472.can-05-1728;
RA Pajer P., Pecenka V., Kralova J., Karafiat V., Prukova D., Zemanova Z.,
RA Kodet R., Dvorak M.;
RT "Identification of potential human oncogenes by mapping the common viral
RT integration sites in avian nephroblastoma.";
RL Cancer Res. 66:78-86(2006).
CC -!- FUNCTION: Transcriptional repressor. {ECO:0000250|UniProtKB:Q9H334}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H334}.
CC -!- DOMAIN: The leucine-zipper is required for dimerization and
CC transcriptional repression. {ECO:0000250|UniProtKB:P58462}.
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DR EMBL; AY935991; AAX36029.1; -; mRNA.
DR RefSeq; NP_001019998.1; NM_001024827.1.
DR RefSeq; XP_015148600.1; XM_015293114.1.
DR RefSeq; XP_015148601.1; XM_015293115.1.
DR RefSeq; XP_015148602.1; XM_015293116.1.
DR AlphaFoldDB; Q58NQ4; -.
DR SMR; Q58NQ4; -.
DR STRING; 9031.ENSGALP00000012592; -.
DR PaxDb; Q58NQ4; -.
DR Ensembl; ENSGALT00000075651; ENSGALP00000044290; ENSGALG00000007769.
DR GeneID; 416092; -.
DR KEGG; gga:416092; -.
DR CTD; 27086; -.
DR VEuPathDB; HostDB:geneid_416092; -.
DR eggNOG; KOG4385; Eukaryota.
DR GeneTree; ENSGT00940000159892; -.
DR HOGENOM; CLU_019502_3_1_1; -.
DR InParanoid; Q58NQ4; -.
DR OMA; GHAYCTP; -.
DR OrthoDB; 836427at2759; -.
DR PhylomeDB; Q58NQ4; -.
DR PRO; PR:Q58NQ4; -.
DR Proteomes; UP000000539; Chromosome 12.
DR Bgee; ENSGALG00000007769; Expressed in granulocyte and 13 other tissues.
DR ExpressionAtlas; Q58NQ4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008045; P:motor neuron axon guidance; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021517; P:ventral spinal cord development; IEP:UniProtKB.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032354; FOXP-CC.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16159; FOXP-CC; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..686
FT /note="Forkhead box protein P1"
FT /id="PRO_0000294520"
FT ZN_FING 315..340
FT /note="C2H2-type"
FT DNA_BIND 474..564
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..378
FT /note="Leucine-zipper"
FT REGION 391..395
FT /note="CTBP1-binding"
FT /evidence="ECO:0000250"
FT REGION 403..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 686 AA; 76826 MW; CF58EB8C05BFB029 CRC64;
MMQESGTETK SNGSAIQNGA SGGNHLLECS LREVRSNGET PSVEIGAADL THLQQQQALQ
VARQLLLQQQ QQQQQQQQQQ QQQQVSGLKS PKRNDKQPAL QVPVSVAMMT PQVITPQQMQ
QILQQQVLTP QQLQVLLQQQ QALMLQQQQL QEFYKKQQEQ LQLQLLQQQH AGKQPKEPQQ
QQVATQQLAF QQQLLQMQQL QQQHLLTLQR QGLLTIQPGQ PTLPLQPLAQ GMIPTELQQL
WKEVTSSHTA EEAASNNHSS LDLSTTCVSS SAPSKTSLII NPHASTNGQL SVHTPKRESL
SHEEHSHSHP LYGHGVCKWP GCEAVCEDFQ SFLKHLNSEH ALDDRSTAQC RVQMQVVQQL
ELQLAKDKER LQAMMTHLHV KSTEPKATPQ PLNLVSSVTL SKTASEASPQ SLPHTPTTPT
APITPVTQGP SVITTTSMHN VGPIRRRYSD KYNVPISSAD IAQNQEFYKN AEVRPPFTYA
SLIRQAILES PEKQLTLNEI YNWFTRMFAY FRRNAATWKN AVRHNLSLHK CFVRVENVKG
AVWTVDEQEF QKRRPQKISG NPSLIKNIQT SHTYCTPLNA ALQASMAENS IPLYTTASMG
NPTLGNLANV MREELNGAME HTNSNGSDSS PGRSPMQAMH PVHVKEEPLD PDENEGPLSL
VTTANHSPDF DHDRDYEDEP VNEDIE
