FOXQ1_RAT
ID FOXQ1_RAT Reviewed; 399 AA.
AC Q63244;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 3.
DT 25-MAY-2022, entry version 150.
DE RecName: Full=Forkhead box protein Q1;
DE AltName: Full=HNF-3/forkhead-like protein 1;
DE Short=HFH-1;
DE AltName: Full=Hepatocyte nuclear factor 3 forkhead homolog 1;
GN Name=Foxq1; Synonyms=Hfh1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-65.
RC STRAIN=Wistar;
RX PubMed=15326124; DOI=10.1167/iovs.04-0302;
RA Ahmed F., Torrado M., Zinovieva R.D., Senatorov V.V., Wistow G.,
RA Tomarev S.I.;
RT "Gene expression profile of the rat eye iridocorneal angle: NEIBank
RT expressed sequence tag analysis.";
RL Invest. Ophthalmol. Vis. Sci. 45:3081-3090(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 8-399.
RC STRAIN=Sprague-Dawley; TISSUE=Lung;
RX PubMed=7683413; DOI=10.1073/pnas.90.9.3948;
RA Clevidence D.E., Overdier D.G., Tao W., Qian X., Pani L., Lai E.,
RA Costa R.H.;
RT "Identification of nine tissue-specific transcription factors of the
RT hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:3948-3952(1993).
CC -!- FUNCTION: Plays a role in hair follicle differentiation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA74561.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; DV214562; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; L13201; AAA74561.1; ALT_FRAME; mRNA.
DR PIR; I60916; I60916.
DR PDB; 1KQ8; NMR; -; A=114-213.
DR PDBsum; 1KQ8; -.
DR AlphaFoldDB; Q63244; -.
DR SMR; Q63244; -.
DR UCSC; RGD:621572; rat.
DR RGD; 621572; Foxq1.
DR InParanoid; Q63244; -.
DR PhylomeDB; Q63244; -.
DR EvolutionaryTrace; Q63244; -.
DR PRO; PR:Q63244; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0031069; P:hair follicle morphogenesis; ISO:RGD.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..399
FT /note="Forkhead box protein Q1"
FT /id="PRO_0000091892"
FT DNA_BIND 114..205
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 41
FT /note="G -> S (in Ref. 1; DV214562)"
FT /evidence="ECO:0000305"
FT CONFLICT 55..58
FT /note="SGAG -> RSAV (in Ref. 1; DV214562)"
FT /evidence="ECO:0000305"
FT CONFLICT 62
FT /note="G -> S (in Ref. 1; DV214562)"
FT /evidence="ECO:0000305"
FT HELIX 121..128
FT /evidence="ECO:0007829|PDB:1KQ8"
FT STRAND 131..134
FT /evidence="ECO:0007829|PDB:1KQ8"
FT HELIX 138..148
FT /evidence="ECO:0007829|PDB:1KQ8"
FT HELIX 152..154
FT /evidence="ECO:0007829|PDB:1KQ8"
FT HELIX 160..170
FT /evidence="ECO:0007829|PDB:1KQ8"
FT STRAND 183..185
FT /evidence="ECO:0007829|PDB:1KQ8"
SQ SEQUENCE 399 AA; 41079 MW; DFFFDBBA7B04F780 CRC64;
MKLEVFAPRA AHGDKMGSDL EGAGSSDVPS PLSAAGDDSL GSDGDCAANS PAAGSGAGDL
EGGGGERNSS GGASTQDDPE VTDGSRTQAS PVGPCAGSVG GGEGARSKPY TRRPKPPYSY
IALIAMAIRD SAGGRLTLAE INEYLMGKFP FFRGSYTGWR NSVRHNLSLN DCFVKVLRDP
SRPWGKDNYW MLNPNSEYTF ADGVFRRRRK RLSHRTTVSA SGYGGGSPPG PAGTPQPAPT
AGSSPIARSP ARQEEGSSPA SKFSSSFAID SILSKPFRSR RDGTPALGVQ LPWSAAPCPP
LRAYPALLPA SSGGALLPLC AYGAAEPTLL ASRGAEVQPA APLFVAPLST AAPAKPFRGP
ETAGAAHLYC PLRLPTALQA AAACGPGPHL SYRVETLLA
