FOXR1_MOUSE
ID FOXR1_MOUSE Reviewed; 268 AA.
AC Q3UTB7;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Forkhead box protein R1;
DE AltName: Full=Forkhead box protein N5;
GN Name=Foxr1; Synonyms=Foxn5, Gm1115;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND SUBCELLULAR LOCATION.
RX PubMed=25609838; DOI=10.1095/biolreprod.114.126250;
RA Petit F.G., Kervarrec C., Jamin S.P., Smagulova F., Hao C., Becker E.,
RA Jegou B., Chalmel F., Primig M.;
RT "Combining RNA and protein profiling data with network interactions
RT identifies genes associated with spermatogenesis in mouse and human.";
RL Biol. Reprod. 92:71-71(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25609838}.
CC Cytoplasm, perinuclear region {ECO:0000269|PubMed:25609838}.
CC Note=Located in the cytoplasm of spermatocytes and strongly accumulates
CC at the perinuclear region in elongated spermatids.
CC {ECO:0000269|PubMed:25609838}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3UTB7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UTB7-2; Sequence=VSP_021113, VSP_021114;
CC -!- TISSUE SPECIFICITY: Expressed in adult germ cells (at protein level).
CC {ECO:0000269|PubMed:25609838}.
CC -!- DEVELOPMENTAL STAGE: Weakly expressed in embryonic gonads.
CC {ECO:0000269|PubMed:25609838}.
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DR EMBL; AK139562; BAE24063.1; -; mRNA.
DR EMBL; AC122428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS23111.1; -. [Q3UTB7-2]
DR RefSeq; NP_001028641.1; NM_001033469.2. [Q3UTB7-2]
DR AlphaFoldDB; Q3UTB7; -.
DR SMR; Q3UTB7; -.
DR STRING; 10090.ENSMUSP00000096436; -.
DR iPTMnet; Q3UTB7; -.
DR PhosphoSitePlus; Q3UTB7; -.
DR PaxDb; Q3UTB7; -.
DR PRIDE; Q3UTB7; -.
DR Antibodypedia; 32552; 92 antibodies from 24 providers.
DR DNASU; 382074; -.
DR Ensembl; ENSMUST00000098837; ENSMUSP00000096436; ENSMUSG00000074397. [Q3UTB7-2]
DR GeneID; 382074; -.
DR KEGG; mmu:382074; -.
DR UCSC; uc009pdr.1; mouse. [Q3UTB7-2]
DR CTD; 283150; -.
DR MGI; MGI:2685961; Foxr1.
DR VEuPathDB; HostDB:ENSMUSG00000074397; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000162579; -.
DR HOGENOM; CLU_108077_0_0_1; -.
DR InParanoid; Q3UTB7; -.
DR OMA; SIQRCMS; -.
DR OrthoDB; 912825at2759; -.
DR PhylomeDB; Q3UTB7; -.
DR BioGRID-ORCS; 382074; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q3UTB7; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q3UTB7; protein.
DR Bgee; ENSMUSG00000074397; Expressed in primary oocyte and 13 other tissues.
DR ExpressionAtlas; Q3UTB7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; DNA-binding; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..268
FT /note="Forkhead box protein R1"
FT /id="PRO_0000253779"
FT DNA_BIND 149..248
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 91..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 181..223
FT /note="EHFPFFRTAPEAWKNTVRHNLSFRDSFEKVPASRQGGASTGPR -> QNICL
FT LSAQEHNHSYPFATYNPAVPQIPILLGRYSFSYPVPKD (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021113"
FT VAR_SEQ 224..268
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021114"
SQ SEQUENCE 268 AA; 30579 MW; E944AC7A39C5B7B8 CRC64;
MGNECFLTFT TTHLSEAEQK LALYRLQLVE PPKLPLEKKT NPDKDGPDIK PNLWMWVNPN
MVYPPGKLEV AVKEEDQSAL SAFQPALKEE EDSCSEASEV QQPLPPCRQK RKQRRSTVPL
PLAPGRRAPL ENPWRLPQAI SPEGRLWSRP PLHYFHLIAL ALRNSPPCGL SVQQIYSFTR
EHFPFFRTAP EAWKNTVRHN LSFRDSFEKV PASRQGGAST GPRSCLWKLT EEGHRRFSKE
ARTLASTQLQ SIQQCMSQPG VKPFLFDL
