ID   FOXR2_MOUSE             Reviewed;         302 AA.
AC   Q3UM89; A2AG72; B2RXE0;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Forkhead box protein R2;
DE   AltName: Full=Forkhead box protein N6;
GN   Name=Foxr2; Synonyms=Foxn6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=15202009;
RA   Katoh M., Katoh M.;
RT   "Identification and characterization of human FOXN6, mouse Foxn6, and rat
RT   Foxn6 genes in silico.";
RL   Int. J. Oncol. 25:219-223(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in 9.5 dpc embryo.
CC       {ECO:0000269|PubMed:15202009}.
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DR   EMBL; AK145057; BAE26209.1; -; mRNA.
DR   EMBL; AL672293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC151186; AAI51187.1; -; mRNA.
DR   CCDS; CCDS30479.1; -.
DR   RefSeq; NP_001030066.1; NM_001034894.3.
DR   RefSeq; XP_011246143.1; XM_011247841.1.
DR   RefSeq; XP_017174032.1; XM_017318543.1.
DR   AlphaFoldDB; Q3UM89; -.
DR   SMR; Q3UM89; -.
DR   STRING; 10090.ENSMUSP00000093984; -.
DR   iPTMnet; Q3UM89; -.
DR   PhosphoSitePlus; Q3UM89; -.
DR   MaxQB; Q3UM89; -.
DR   PaxDb; Q3UM89; -.
DR   PeptideAtlas; Q3UM89; -.
DR   PRIDE; Q3UM89; -.
DR   Antibodypedia; 12993; 126 antibodies from 25 providers.
DR   DNASU; 436240; -.
DR   Ensembl; ENSMUST00000096265; ENSMUSP00000093984; ENSMUSG00000071665.
DR   Ensembl; ENSMUST00000163801; ENSMUSP00000128452; ENSMUSG00000071665.
DR   GeneID; 436240; -.
DR   KEGG; mmu:436240; -.
DR   UCSC; uc009uqs.2; mouse.
DR   CTD; 139628; -.
DR   MGI; MGI:3511682; Foxr2.
DR   VEuPathDB; HostDB:ENSMUSG00000071665; -.
DR   eggNOG; KOG2294; Eukaryota.
DR   GeneTree; ENSGT00940000162993; -.
DR   HOGENOM; CLU_077699_3_1_1; -.
DR   InParanoid; Q3UM89; -.
DR   OMA; DMNEEIN; -.
DR   OrthoDB; 912825at2759; -.
DR   PhylomeDB; Q3UM89; -.
DR   TreeFam; TF329867; -.
DR   BioGRID-ORCS; 436240; 2 hits in 71 CRISPR screens.
DR   PRO; PR:Q3UM89; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q3UM89; protein.
DR   Bgee; ENSMUSG00000071665; Expressed in epiblast (generic) and 12 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..302
FT                   /note="Forkhead box protein R2"
FT                   /id="PRO_0000253781"
FT   DNA_BIND        183..285
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
SQ   SEQUENCE   302 AA;  35036 MW;  D3AD63F1DC40BBE5 CRC64;
     MDVKVKNRDF WYSLHGQVPG MLDWDMGNEF FLPCTMDQCS FAEQSLAKYK IQLTKPPALP
     QKKKSNFDDD GPPAEPSLWM WVNPNIVCPI NSKEAPNTIH KILPSAPFPQ TGESDYLGTQ
     RMVQSLSVLH TEHHQQQKLL IYSTAPDFIE EETKEQECTS SKKYSKKHTV CHGPHREKES
     WPRPPLNYSH LVALALKSSP SCGLNVQQIY NFTRQHFPYF RTAPEGWKNT IRHNLCSLTC
     FEKVPVDLED EPDGKPRSFL WKLTDEGNRF FQEDTRVLAY ARRESIKQSM RQPELIDLLF
     HL