FOXS1_MOUSE
ID FOXS1_MOUSE Reviewed; 329 AA.
AC Q61574; Q8C5N7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Forkhead box protein S1;
DE AltName: Full=Forkhead-like 18 protein;
DE AltName: Full=Forkhead-related transcription factor 10;
DE Short=FREAC-10;
DE AltName: Full=Transcription factor FKH-3;
GN Name=Foxs1; Synonyms=Fkh3, Fkhl18, Freac10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-119.
RC STRAIN=129;
RX PubMed=7689224; DOI=10.1073/pnas.90.16.7628;
RA Kaestner K.H., Lee K.H., Schloendorff J., Hiemisch H., Monaghan A.P.,
RA Schuetz G.;
RT "Six members of the mouse forkhead gene family are developmentally
RT regulated.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:7628-7631(1993).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=18288644; DOI=10.1002/mrd.20888;
RA Sato Y., Baba T., Zubair M., Miyabayashi K., Toyama Y., Maekawa M.,
RA Owaki A., Mizusaki H., Sawamura T., Toshimori K., Morohashi K.,
RA Katoh-Fukui Y.;
RT "Importance of forkhead transcription factor Fkhl18 for development of
RT testicular vasculature.";
RL Mol. Reprod. Dev. 75:1361-1371(2008).
CC -!- FUNCTION: Transcriptional repressor that suppresses transcription from
CC the FASLG, FOXO3 and FOXO4 promoters. May have a role in the
CC organization of the testicular vasculature.
CC {ECO:0000269|PubMed:18288644}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089,
CC ECO:0000269|PubMed:18288644}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the testis in Sertoli and
CC periendothelial cells at 14 dpc. {ECO:0000269|PubMed:18288644}.
CC -!- DISRUPTION PHENOTYPE: Accumulation of blood in the central part of the
CC fetal testis. Increased ectopic apoptosis in periendothelial cells of
CC the testis. {ECO:0000269|PubMed:18288644}.
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DR EMBL; AK077935; BAC37074.1; -; mRNA.
DR EMBL; X71941; CAA50743.1; -; Genomic_DNA.
DR CCDS; CCDS16901.1; -.
DR PIR; C47746; C47746.
DR RefSeq; NP_034356.1; NM_010226.2.
DR AlphaFoldDB; Q61574; -.
DR SMR; Q61574; -.
DR STRING; 10090.ENSMUSP00000096806; -.
DR iPTMnet; Q61574; -.
DR PhosphoSitePlus; Q61574; -.
DR PaxDb; Q61574; -.
DR PRIDE; Q61574; -.
DR ProteomicsDB; 267622; -.
DR Antibodypedia; 25256; 88 antibodies from 21 providers.
DR DNASU; 14239; -.
DR Ensembl; ENSMUST00000099200; ENSMUSP00000096806; ENSMUSG00000074676.
DR GeneID; 14239; -.
DR KEGG; mmu:14239; -.
DR UCSC; uc008ngt.1; mouse.
DR CTD; 2307; -.
DR MGI; MGI:95546; Foxs1.
DR VEuPathDB; HostDB:ENSMUSG00000074676; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000162811; -.
DR HOGENOM; CLU_839247_0_0_1; -.
DR InParanoid; Q61574; -.
DR OMA; HYIMGRF; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q61574; -.
DR TreeFam; TF316127; -.
DR BioGRID-ORCS; 14239; 3 hits in 74 CRISPR screens.
DR PRO; PR:Q61574; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q61574; protein.
DR Bgee; ENSMUSG00000074676; Expressed in ureteric bud trunk and 76 other tissues.
DR ExpressionAtlas; Q61574; baseline and differential.
DR Genevisible; Q61574; MM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0001568; P:blood vessel development; IMP:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..329
FT /note="Forkhead box protein S1"
FT /id="PRO_0000091894"
FT DNA_BIND 17..108
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 117..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 329 AA; 35567 MW; E0196C8408AEA6AD CRC64;
MQKQPSPESL APSAEPTKPP YSYIALIAMA IQSSPGQRAT LSGIYRYIMG RFAFYRHNRP
GWQNSIRHNL SLNECFVKVP RDDRKPGKGS YWTLDPDCHD MFQHGSFLRR RRRFTKRTGA
QGTKGPVKID HRPHRATSPD PGAPKTTTGR LCPFPQEVPN PKGLSFEGLM GSLPANMSST
TSDVRPQLPT GPKEMCSAKS GGPRELSEAT SPSPCPAFGF SSAFSDAESL GKAPTPGVAP
ESVGSSYQCR MQTLNFCMGT DPGLEHLLVS SVPTPGSSTP SASHRAPLPL PADSKEPWVA
GSFPVQGGSG YPLGLPPCLY RTPGMFFFE
