FP100_MOUSE
ID FP100_MOUSE Reviewed; 879 AA.
AC A2ACJ2; Q0P653; Q810W2;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Fanconi anemia core complex-associated protein 100 {ECO:0000250|UniProtKB:Q0VG06};
DE AltName: Full=Fanconi anemia-associated protein of 100 kDa;
GN Name=Faap100 {ECO:0000250|UniProtKB:Q0VG06};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-879.
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in Fanconi anemia-associated DNA damage response
CC network. Regulates FANCD2 monoubiquitination and the stability of the
CC FA core complex. Induces chromosomal instability as well as
CC hypersensitivity to DNA cross-linking agents, when repressed (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Belongs to the multisubunit FA complex composed of FANCA,
CC FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and
CC FAAP100. Forms a subcomplex with FANCB and FANCL (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH34203.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH48376.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AK148234; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK148234; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL669855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034203; AAH34203.1; ALT_INIT; mRNA.
DR EMBL; BC048376; AAH48376.1; ALT_INIT; mRNA.
DR CCDS; CCDS49004.1; -.
DR RefSeq; NP_082256.2; NM_027980.2.
DR AlphaFoldDB; A2ACJ2; -.
DR SMR; A2ACJ2; -.
DR BioGRID; 215005; 9.
DR IntAct; A2ACJ2; 8.
DR STRING; 10090.ENSMUSP00000026448; -.
DR iPTMnet; A2ACJ2; -.
DR PhosphoSitePlus; A2ACJ2; -.
DR EPD; A2ACJ2; -.
DR MaxQB; A2ACJ2; -.
DR PaxDb; A2ACJ2; -.
DR PRIDE; A2ACJ2; -.
DR ProteomicsDB; 271718; -.
DR Antibodypedia; 19824; 70 antibodies from 17 providers.
DR DNASU; 71885; -.
DR Ensembl; ENSMUST00000026448; ENSMUSP00000026448; ENSMUSG00000025384.
DR GeneID; 71885; -.
DR KEGG; mmu:71885; -.
DR UCSC; uc007msm.2; mouse.
DR CTD; 80233; -.
DR MGI; MGI:1919135; Faap100.
DR VEuPathDB; HostDB:ENSMUSG00000025384; -.
DR eggNOG; ENOG502QTI0; Eukaryota.
DR GeneTree; ENSGT00390000016682; -.
DR HOGENOM; CLU_018470_0_0_1; -.
DR InParanoid; A2ACJ2; -.
DR OMA; MYHSTPS; -.
DR OrthoDB; 129283at2759; -.
DR PhylomeDB; A2ACJ2; -.
DR TreeFam; TF330817; -.
DR Reactome; R-MMU-6783310; Fanconi Anemia Pathway.
DR BioGRID-ORCS; 71885; 29 hits in 75 CRISPR screens.
DR ChiTaRS; Faap100; mouse.
DR PRO; PR:A2ACJ2; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; A2ACJ2; protein.
DR Bgee; ENSMUSG00000025384; Expressed in retinal neural layer and 201 other tissues.
DR Genevisible; A2ACJ2; MM.
DR GO; GO:0000785; C:chromatin; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0043240; C:Fanconi anaemia nuclear complex; IEA:InterPro.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:InterPro.
DR GO; GO:0006513; P:protein monoubiquitination; ISO:MGI.
DR InterPro; IPR029251; Faap100.
DR PANTHER; PTHR14890; PTHR14890; 1.
DR Pfam; PF15146; FANCAA; 1.
PE 2: Evidence at transcript level;
KW DNA damage; DNA repair; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..879
FT /note="Fanconi anemia core complex-associated protein 100"
FT /id="PRO_0000289131"
FT CONFLICT 436
FT /note="S -> P (in Ref. 1; AK148234)"
FT /evidence="ECO:0000305"
FT CONFLICT 856
FT /note="S -> G (in Ref. 1; AK148234)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 879 AA; 94281 MW; 83F2DF42485E2F50 CRC64;
MAGASSRVHY LSDFCCPLGG RAAGKPFVLR HEAEVFLSTG REFVYVYDQE GGLLTAVYQF
PDQVWHLQLL AIRRALYVLC ARTGIYCLSL DSLDRSGSQA CEDKEEAAPP YPVIHVDPDA
CVLPDAALCA FTVLDDMLVT LAQGPTQWKM QLFERPCAGE EPLPRGQIGE VELSTCTPPG
GVPEKPAAPR FLPVLCCVFP PDSRAPHGHP QGCGCFTLEE ALFGLLFGVD ATLLQSPVIL
CGLPDGQLCC VVLKALVTSG LAPGDPKVLV KILHHLEEPV IFIGALRAEP HEEEAAGELL
PGQHEHSDCL VALGHQGRTL AIKASWSESG NLVPELREYC LPGPVLCAAC DRDGHVYHST
PSDLCVVDLT RRDSPWNPEK PDGAIGGLPS VLCPASLNIC SALALCVTAR APTGSTELLA
LSSKGRLITC SLDLNSEAPV PAKMAMANAG QKIKELLLDI GDVSERVSFL KKAVDQRNKA
ITSLNEAMNV SCALLSHPEG DRPIACTITT SWSRLELRDM LMATCTLENS SSFSLDQGWT
LCIQVLTSSS ALDLDGTGSA FTYTIPVDRL GPGSRREVTL PLGPSESGVL DLPVTMSCWL
FYSLREVVGA ALAPSDPLEA PYLEQFPLSL PKQEGVCLPL CKRTVDMLQC LRFAGAATHP
AQAPCMPGPA CEPVETFLKT CQAPGSEPTG AASLRAKYLP PSTASIRVSA GLLRAALEDS
HSGFHLCSAT LRWLLAENAA VDVVRAQTLS SIQGIAPDGT DVNLTVHEVA VTDLSPAGPI
QAVEIQVESS SLANMCRAHH AIIRRIQTMV TEQAALGSSP PDLRMQYLQQ IHANHQELLR
EVQALRDQLC TEDELSSCST AQKLLHIYKQ LRNPSLVLL
