FP1_MYTCO
ID FP1_MYTCO Reviewed; 872 AA.
AC Q25434;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Adhesive plaque matrix protein;
DE AltName: Full=Foot protein 1;
DE AltName: Full=MCFP1;
DE Flags: Precursor;
GN Name=FP1;
OS Mytilus coruscus (Sea mussel).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC Mytilus.
OX NCBI_TaxID=42192;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Foot;
RX PubMed=8798340; DOI=10.1007/bf02339009;
RA Inoue K., Takeuchi Y., Takeyama S., Yamaha E., Yamazaki F., Odo S.,
RA Harayama S.;
RT "Adhesive protein cDNA sequence of the mussel Mytilus coruscus and its
RT evolutionary implications.";
RL J. Mol. Evol. 43:348-356(1996).
CC -!- FUNCTION: Provides adhesiveness to the mussel's foot. Mussels produce
CC one of the strongest water insoluble glues. The mussel's adhesive is a
CC bundle of threads, called a byssus, formed by a fibrous collagenous
CC core coated with adhesive proteins.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Produced by the byssal gland.
CC -!- DOMAIN: Almost exclusively composed of repeats of a decapeptide.
CC -!- PTM: Hydroxylated on proline (mono- or dihydroxylation) and tyrosine
CC residues (to L-DOPA = 3',4'-dihydroxyphenylalanine) of the tandem
CC repeats.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=Sticky business - Issue 2 of
CC September 2001;
CC URL="https://web.expasy.org/spotlight/back_issues/002";
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DR EMBL; D63777; BAA09850.1; -; mRNA.
DR AlphaFoldDB; Q25434; -.
DR PRIDE; Q25434; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR002964; Adhesive_plaq.
DR PRINTS; PR01216; ADHESIVEI.
PE 2: Evidence at transcript level;
KW Hydroxylation; Repeat; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..872
FT /note="Adhesive plaque matrix protein"
FT /id="PRO_0000021285"
FT REPEAT 124..133
FT /note="1"
FT REPEAT 134..143
FT /note="2"
FT REPEAT 144..153
FT /note="3"
FT REPEAT 154..163
FT /note="4"
FT REPEAT 174..183
FT /note="5"
FT REPEAT 184..192
FT /note="6"
FT REPEAT 193..202
FT /note="7"
FT REPEAT 203..212
FT /note="8"
FT REPEAT 213..221
FT /note="9"
FT REPEAT 222..231
FT /note="10"
FT REPEAT 232..241
FT /note="11"
FT REPEAT 242..251
FT /note="12"
FT REPEAT 252..261
FT /note="13"
FT REPEAT 262..271
FT /note="14"
FT REPEAT 272..281
FT /note="15"
FT REPEAT 282..291
FT /note="16"
FT REPEAT 292..301
FT /note="17"
FT REPEAT 302..311
FT /note="18"
FT REPEAT 312..321
FT /note="19"
FT REPEAT 322..331
FT /note="20"
FT REPEAT 332..341
FT /note="21"
FT REPEAT 342..351
FT /note="22"
FT REPEAT 352..361
FT /note="23"
FT REPEAT 362..371
FT /note="24"
FT REPEAT 372..381
FT /note="25"
FT REPEAT 382..391
FT /note="26"
FT REPEAT 402..411
FT /note="27"
FT REPEAT 412..421
FT /note="28"
FT REPEAT 422..431
FT /note="29"
FT REPEAT 432..441
FT /note="30"
FT REPEAT 442..451
FT /note="31"
FT REPEAT 452..461
FT /note="32"
FT REPEAT 462..471
FT /note="33"
FT REPEAT 472..481
FT /note="34"
FT REPEAT 482..491
FT /note="35"
FT REPEAT 502..511
FT /note="36"
FT REPEAT 512..521
FT /note="37"
FT REPEAT 522..531
FT /note="38"
FT REPEAT 532..541
FT /note="39"
FT REPEAT 542..551
FT /note="40"
FT REPEAT 552..561
FT /note="41"
FT REPEAT 562..571
FT /note="42"
FT REPEAT 572..581
FT /note="43"
FT REPEAT 582..591
FT /note="44"
FT REPEAT 602..611
FT /note="45"
FT REPEAT 612..621
FT /note="46"
FT REPEAT 622..631
FT /note="47"
FT REPEAT 632..641
FT /note="48"
FT REPEAT 642..651
FT /note="49"
FT REPEAT 652..661
FT /note="50"
FT REPEAT 662..671
FT /note="51"
FT REPEAT 672..681
FT /note="52"
FT REPEAT 682..691
FT /note="53"
FT REPEAT 702..711
FT /note="54"
FT REPEAT 712..721
FT /note="55"
FT REPEAT 722..731
FT /note="56"
FT REPEAT 732..741
FT /note="57"
FT REPEAT 742..751
FT /note="58"
FT REPEAT 752..761
FT /note="59"
FT REPEAT 762..771
FT /note="60"
FT REPEAT 772..781
FT /note="61"
FT REPEAT 782..791
FT /note="62"
FT REPEAT 792..801
FT /note="63"
FT REPEAT 812..821
FT /note="64"
FT REPEAT 822..831
FT /note="65"
FT REPEAT 832..841
FT /note="66"
FT REPEAT 842..851
FT /note="67"
FT REPEAT 852..861
FT /note="68"
FT REPEAT 862..871
FT /note="69"
FT REGION 21..41
FT /note="Nonrepetitive linker"
FT REGION 124..871
FT /note="69 X 10 AA tandem repeats of Y-[KRQ]-[PSTAHQR]-K-
FT [AIPTSKGV]-[STR]-Y-[PTSVA]-[PSTQA]-[STYIPAQ]"
FT REGION 184..192
FT /note="Nonapeptide 1"
FT REGION 213..221
FT /note="Nonapeptide 2"
FT REGION 273..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..326
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..373
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..417
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..486
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..606
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..657
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..697
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 872 AA; 101678 MW; 98CC70D7C75FF3C4 CRC64;
MEGIKLNLCL LCIFSCDIFA LSNGNIHNVY GSAYSGASAG AYKTLPGSHP YGSKHVPVYK
PMNKIPTPYI SKKSYPAPYK PKGYYPTKRY QPTYGSKTNY PPIYKPIAKK LSSYKAIKTT
YPAYKAKTSY PPSYKHKITY PPTYKPKITY PPTYKQKPSY PPSYKPKTTY PPTYKPKITY
PPTYKRKPSY TPYKPKATYP PTYKPKITYP PTYKRKPSYT PYKPKTTYPP TYKPKISYPS
IYKPKASYVS SYKSKKTYPP TYKPKISYPP TYKPKPSYPP TYKPKVTYPP TYKPKPSYPP
TYKPKITYPP TYKPKPSYPT PYKQKPSYPP IYKSKSSYPT SYKSKKTYPP TYKPKITYPP
TYKPKPSYPP SYKPKKTYSP TYKPKITYPP TYKPKPSYPP SYKPKTTYPP TYKPKISYPP
TYKPKASYVS SYKSKKTYPP TYKPKISYPP TYKPKPSYPP TYKPKITYPP TYKPKPSYPP
TYKPKITYPP TYKRKPSYPT PYKQKPSYPP IYKSKSSYPT SYKSKKTYPP TYKPKITYPP
TYKPKPSYPP SYKPKTTYPP TYKPKIRYPP TYKPKASYPP TYKPKITYPP TYKPKPSYPT
PYKQKPSYPP IYKSKSSYPT AYKSKKTYPP TYKPKITYPP TYKPKPSYPP SYRPKITYPP
TYKPKKSYPQ AYKSKGSYPP SYQPKKTYPP SYKPKKTYPP TYKPKISYPP TYKTKPSYPA
SYKRKTSYPP TYKPKISYPS TYKAKPSYPP TYKPKPSYAS SYKPKIRYPP TYKPKPSYAS
SYKPKIRYPP TYKPKPSYAS SYKPKIRYPP TYKPKPSYAS SYKPKITYPP TYKPKISYPP
TYKPKITYPP TYKPKISYPP AYKPKISYPS QY
