FP1_MYTGA
ID FP1_MYTGA Reviewed; 751 AA.
AC Q27409;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Adhesive plaque matrix protein;
DE AltName: Full=Foot protein 1;
DE AltName: Full=MGFP-1;
DE Short=MGFP1;
DE Flags: Precursor;
GN Name=FP1;
OS Mytilus galloprovincialis (Mediterranean mussel).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC Mytilus.
OX NCBI_TaxID=29158;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Foot;
RX PubMed=8043658; DOI=10.2307/1542281;
RA Inoue K., Odo S.;
RT "The adhesive protein cDNA of Mytilus galloprovincialis encodes decapeptide
RT repeats but no hexapeptide motif.";
RL Biol. Bull. 186:349-355(1994).
CC -!- FUNCTION: Provides adhesiveness to the mussel's foot. Mussels produce
CC one of the strongest water insoluble glues. The mussel's adhesive is a
CC bundle of threads, called a byssus, formed by a fibrous collagenous
CC core coated with adhesive proteins.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Produced by the byssal gland.
CC -!- DOMAIN: Almost exclusively composed of repeats of a decapeptide.
CC -!- PTM: Hydroxylated on proline (mono- or dihydroxylation) and tyrosine
CC residues (to L-DOPA = 3',4'-dihydroxyphenylalanine) of the tandem
CC repeats. {ECO:0000250}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=Sticky business - Issue 2 of
CC September 2001;
CC URL="https://web.expasy.org/spotlight/back_issues/002";
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DR EMBL; D63778; BAA09851.1; -; mRNA.
DR PIR; S68957; S68957.
DR AlphaFoldDB; Q27409; -.
DR PRIDE; Q27409; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR002964; Adhesive_plaq.
DR PRINTS; PR01216; ADHESIVEI.
PE 2: Evidence at transcript level;
KW Hydroxylation; Repeat; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..751
FT /note="Adhesive plaque matrix protein"
FT /id="PRO_0000021286"
FT REPEAT 109..118
FT /note="1"
FT REPEAT 119..128
FT /note="2"
FT REPEAT 129..138
FT /note="3"
FT REPEAT 139..148
FT /note="4"
FT REPEAT 149..158
FT /note="5"
FT REPEAT 159..168
FT /note="6"
FT REPEAT 169..178
FT /note="7"
FT REPEAT 179..188
FT /note="8"
FT REPEAT 189..198
FT /note="9"
FT REPEAT 199..208
FT /note="10"
FT REPEAT 209..218
FT /note="11"
FT REPEAT 219..228
FT /note="12"
FT REPEAT 229..238
FT /note="13"
FT REPEAT 239..248
FT /note="14"
FT REPEAT 249..258
FT /note="15"
FT REPEAT 259..268
FT /note="16"
FT REPEAT 269..278
FT /note="17"
FT REPEAT 279..288
FT /note="18"
FT REPEAT 289..298
FT /note="19"
FT REPEAT 299..308
FT /note="20"
FT REPEAT 309..318
FT /note="21"
FT REPEAT 319..328
FT /note="22"
FT REPEAT 329..338
FT /note="23"
FT REPEAT 339..348
FT /note="24"
FT REPEAT 349..358
FT /note="25"
FT REPEAT 359..368
FT /note="26"
FT REPEAT 369..378
FT /note="27"
FT REPEAT 379..388
FT /note="28"
FT REPEAT 389..398
FT /note="29"
FT REPEAT 399..408
FT /note="30"
FT REPEAT 409..418
FT /note="31"
FT REPEAT 419..428
FT /note="32"
FT REPEAT 429..438
FT /note="33"
FT REPEAT 439..448
FT /note="34"
FT REPEAT 449..458
FT /note="35"
FT REPEAT 459..468
FT /note="36"
FT REPEAT 469..478
FT /note="37"
FT REPEAT 479..488
FT /note="38"
FT REPEAT 489..498
FT /note="39"
FT REPEAT 499..508
FT /note="40"
FT REPEAT 509..518
FT /note="41"
FT REPEAT 519..528
FT /note="42"
FT REPEAT 529..538
FT /note="43"
FT REPEAT 539..548
FT /note="44"
FT REPEAT 549..558
FT /note="45"
FT REPEAT 559..568
FT /note="46"
FT REPEAT 569..578
FT /note="47"
FT REPEAT 579..588
FT /note="48"
FT REPEAT 589..598
FT /note="49"
FT REPEAT 599..608
FT /note="50"
FT REPEAT 609..618
FT /note="51"
FT REPEAT 619..628
FT /note="52"
FT REPEAT 629..638
FT /note="53"
FT REPEAT 639..648
FT /note="54"
FT REPEAT 649..658
FT /note="55"
FT REPEAT 659..662
FT /note="56; truncated"
FT REPEAT 663..672
FT /note="57"
FT REPEAT 673..682
FT /note="58"
FT REPEAT 683..692
FT /note="59"
FT REPEAT 693..702
FT /note="60"
FT REPEAT 703..712
FT /note="61"
FT REPEAT 713..722
FT /note="62"
FT REPEAT 723..732
FT /note="63"
FT REGION 21..41
FT /note="Nonrepetitive linker"
FT REGION 109..732
FT /note="63 X 10 AA tandem repeats of Y-[KR]-[APTS]-K-
FT [KPMSLTIVA]-[STR]-Y-[PLS]-[PASRQT]-[STI]"
FT REGION 158..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..183
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..354
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..473
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..543
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..636
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..688
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..734
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 751 AA; 85791 MW; E9E8D91C33C95C7D CRC64;
MEGIKLNLCL LCIFTCDILG FSNGNIYNAH GSAYAGASAG AYKTLPNAYP YGTKHGPVYK
PVKTSYHPTN SYPPTYGSKT NYLPLAKKLS SYKPIKTTYN AKTNYPPVYK PKMTYPPTYK
PKPSYPPTYK PKPSYPATYK SKSSYPSSYK PKKTYPPTYK PKLTYPPTYK PKPSYPPTYK
PKPSYPATYK SKSSYPPSYK TKKTYPSSYK PKKTYPSTYK PKVSYPPTYK SKKSYPPIYK
TKASYPSSYK PKKTYPSTYK PKISYPPTYK AKPSYPTSYR AKPSYPSTYK AKPSYPPTYK
AKPSYPPTYK AKPTYPSTYK AKPSYPPTYK AKPSYPPTYK AKPSYPPSYK PKTTYPPSYK
PKISYPPTYK AKPSYPPIYK AKPSYPPTYK AKPSYLPTYK AKPSYPPTYK AKPRYPTTYK
AKPSYPPTYK AKPSYPPTYK AKLSYPPTYK AKPSYPPTYK AKPSYPPTYK AKPSYPPTYK
TKPSYPRTYK AKPSYSSTYK AKPSYPPTYK AKPSYPPTYK AKPSYPPTYK AKPSYPPTYK
AKPSYPPTYK AKPSYPQTYK AKSSYPPTYK AKPSYPPTYK AKPSYPPTYK AKPSYPPTYK
AKPSYPPTYK AKPSYPPTYK AKPSYPPTYK AKPSYPPTYK AKPSYPPTYK AKPSYPATYP
STYKAKPSYP PTYKAKPSYP PTYKPKPSYP PTYKSKSSYP SSYKPKKTYP PTYKPKLTYP
PIYKPKPSYP PTYKSSYPPR YKKKISYPSQ Y
