FP2_MYTGA
ID FP2_MYTGA Reviewed; 473 AA.
AC Q25464;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Adhesive plaque matrix protein 2;
DE AltName: Full=Foot protein 2;
DE AltName: Full=MGFP-2;
DE Short=MGFP2;
DE Flags: Precursor;
GN Name=FP2;
OS Mytilus galloprovincialis (Mediterranean mussel).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC Mytilus.
OX NCBI_TaxID=29158;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Foot;
RX PubMed=7896812; DOI=10.1074/jbc.270.12.6698;
RA Inoue K., Takeuchi Y., Miki D., Odo S.;
RT "Mussel adhesive plaque protein gene is a novel member of epidermal growth
RT factor-like gene family.";
RL J. Biol. Chem. 270:6698-6701(1995).
CC -!- FUNCTION: Provides adhesiveness to the mussel's foot. Mussels produce
CC one of the strongest water insoluble glues. The mussel's adhesive is a
CC bundle of threads, called a byssus, formed by a fibrous collagenous
CC core coated with adhesive proteins.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Produced by the byssal gland.
CC -!- DEVELOPMENTAL STAGE: Expression starts at the pediveliger, foot
CC formation, stage.
CC -!- PTM: Contains L-DOPA (3',4'-dihydroxyphenylalanine). {ECO:0000250}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=Sticky business - Issue 2 of
CC September 2001;
CC URL="https://web.expasy.org/spotlight/back_issues/002";
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DR EMBL; D43794; BAA07852.1; -; mRNA.
DR PIR; A56175; A56175.
DR AlphaFoldDB; Q25464; -.
DR SMR; Q25464; -.
DR PRIDE; Q25464; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR Pfam; PF00008; EGF; 7.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00179; EGF_CA; 10.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 11.
DR PROSITE; PS01186; EGF_2; 10.
DR PROSITE; PS50026; EGF_3; 11.
PE 2: Evidence at transcript level;
KW Disulfide bond; EGF-like domain; Glycoprotein; Hydroxylation; Repeat;
KW Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..473
FT /note="Adhesive plaque matrix protein 2"
FT /id="PRO_0000007588"
FT DOMAIN 45..81
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 82..117
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 118..154
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 155..191
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 192..228
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 229..265
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 266..301
FT /note="EGF-like 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 302..340
FT /note="EGF-like 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 342..378
FT /note="EGF-like 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 383..420
FT /note="EGF-like 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 425..461
FT /note="EGF-like 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT MOD_RES 23
FT /note="3',4'-dihydroxyphenylalanine"
FT /evidence="ECO:0000250"
FT MOD_RES 31
FT /note="3',4'-dihydroxyphenylalanine"
FT /evidence="ECO:0000250"
FT MOD_RES 36
FT /note="3',4'-dihydroxyphenylalanine"
FT /evidence="ECO:0000250"
FT MOD_RES 43
FT /note="3',4'-dihydroxyphenylalanine"
FT /evidence="ECO:0000250"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..60
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 54..69
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 71..80
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 86..97
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 91..106
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 108..117
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 122..133
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 127..143
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 145..154
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 159..170
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 164..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 182..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 196..207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 201..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 219..228
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 233..244
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 238..254
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 256..265
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 270..281
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 275..290
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 292..301
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 306..317
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 311..328
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 330..339
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 346..357
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 351..366
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 368..377
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 387..399
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 393..408
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 410..419
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 429..440
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 434..449
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 451..460
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 473 AA; 51772 MW; BA76BA8C3BA49A0F CRC64;
MLFSFFLLLT CTQLCLGTNR PDYNDDEEDD YKPPVYKPSP SKYRPVNPCL KKPCKYNGVC
KPRGGSYKCF CKGGYYGYNC NLKNACKPNQ CKNKSRCVPV GKTFKCVCRN GNFGRLCEKN
VCSPNPCKNN GKCSPLGKTG YKCTCSGGYT GPRCEVHACK PNPCKNKGRC FPDGKTGYKC
RCVDGYSGPT CQENACKPNP CSNGGTCSAD KFGDYSCECR PGYFGPECER YVCAPNPCKN
GGICSSDGSG GYRCRCKGGY SGPTCKVNVC KPTPCKNSGR CVNKGSSYNC ICKGGYSGPT
CGENVCKPNP CQNRGRCYPD NSDDGFKCRC VGGYKGPTCE DKPNPCNTKP CKNGGKCNYN
GKIYTCKCAY GWRGRHCTDK AYKPNPCVVS KPCKNRGKCI WNGKAYRCKC AYGYGGRHCT
KKSYKKNPCA SRPCKNRGKC TDKGNGYVCK CARGYSGRYC SLKSPPSYDD DEY
