ID   ALBU_LITCT              Reviewed;         382 AA.
AC   P21847;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Albumin;
DE   Flags: Fragment;
GN   Name=ALB;
OS   Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Tadpole liver;
RX   PubMed=1704484; DOI=10.1210/mend-4-10-1556;
RA   Averyhart-Fullard V., Jaffe R.C.;
RT   "Cloning and thyroid hormone regulation of albumin mRNA in Rana catesbeiana
RT   tadpole liver.";
RL   Mol. Endocrinol. 4:1556-1563(1990).
CC   -!- FUNCTION: Serum albumin, the main protein of plasma, has a good binding
CC       capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones,
CC       bilirubin and drugs. Its main function is the regulation of the
CC       colloidal osmotic pressure of blood. {ECO:0000250|UniProtKB:P02768}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Plasma.
CC   -!- SIMILARITY: Belongs to the ALB/AFP/VDB family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00769}.
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DR   EMBL; M38195; AAA63473.1; -; mRNA.
DR   PIR; A37253; A37253.
DR   AlphaFoldDB; P21847; -.
DR   SMR; P21847; -.
DR   GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0036094; F:small molecule binding; IPI:AgBase.
DR   GO; GO:0070324; F:thyroid hormone binding; TAS:AgBase.
DR   CDD; cd00015; ALBUMIN; 2.
DR   InterPro; IPR000264; ALB/AFP/VDB.
DR   InterPro; IPR020858; Serum_albumin-like.
DR   InterPro; IPR020857; Serum_albumin_CS.
DR   InterPro; IPR014760; Serum_albumin_N.
DR   PANTHER; PTHR11385; PTHR11385; 1.
DR   Pfam; PF00273; Serum_albumin; 2.
DR   PRINTS; PR00802; SERUMALBUMIN.
DR   SMART; SM00103; ALBUMIN; 2.
DR   SUPFAM; SSF48552; SSF48552; 2.
DR   PROSITE; PS00212; ALBUMIN_1; 2.
DR   PROSITE; PS51438; ALBUMIN_2; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Disulfide bond; Lipid-binding; Metal-binding; Repeat; Secreted;
KW   Zinc.
FT   CHAIN           <1..382
FT                   /note="Albumin"
FT                   /id="PRO_0000135615"
FT   DOMAIN          <1..178
FT                   /note="Albumin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT   DOMAIN          179..377
FT                   /note="Albumin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT   BINDING         51
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02769"
FT   BINDING         51
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P02768"
FT   BINDING         54
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02769"
FT   DISULFID        2..48
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT   DISULFID        47..55
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT   DISULFID        67..81
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT   DISULFID        80..91
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT   DISULFID        116..161
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT   DISULFID        160..169
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT   DISULFID        192..238
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT   DISULFID        237..248
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT   DISULFID        261..277
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT   DISULFID        276..287
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT   DISULFID        314..359
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT   DISULFID        358..367
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT   NON_TER         1
SQ   SEQUENCE   382 AA;  43920 MW;  1BD981FE808AEA37 CRC64;
     KCRIIREFPD IVFKGLTLVQ VSQKFGKAGF EDVKKVTEEI VHLNEDCCKG DAVECMMERM
     EATDHICEAK DKLSSKLADC CAKSILERTP CLLALPNDES DLSKELKNYY EDERVCENYK
     KDKLLFLAHF THDYARSHQE SSPQSCLRVS KGFEGLLEKC CASENHAECL KQAPILLEAA
     LKEIEELRKQ NCGALQLLGF RDYNIQLLFR YFFKMPQVTA PTLVELAGRM TKVAVYCCGL
     AENKQQTCAE EKLDILLGEM CEKEKHTFVN DNVRHCCVDS YANRRKCFTD LQRYPNYVAP
     KWDESKLHFN EDLCKGSEDD QIKKKLEVLV EYMKMKPDCG PEKLKEVVEA FRKIDIKCCA
     AEDHQKCFDD EKAGLLQIIE AH