ID   ALCA_BORBR              Reviewed;         461 AA.
AC   Q44740; O07956;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2003, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Alcaligin biosynthesis enzyme;
DE            EC=1.-.-.-;
GN   Name=alcA; OrderedLocusNames=BB3893;
OS   Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
OS   (Alcaligenes bronchisepticus).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MBORD846;
RX   PubMed=8566764; DOI=10.1016/0378-1119(95)00659-1;
RA   Giardina P.C., Foster L.A., Toth S.I., Roe B.A., Dyer D.W.;
RT   "Identification of alcA, a Bordetella bronchiseptica gene necessary for
RT   alcaligin production.";
RL   Gene 167:133-136(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-588 / NCTC 13252 / RB50;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- PATHWAY: Siderophore biosynthesis; alcaligin biosynthesis.
CC   -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC       oxygenase family. {ECO:0000305}.
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DR   EMBL; U32117; AAA97596.1; -; Genomic_DNA.
DR   EMBL; U61153; AAB40618.1; -; Genomic_DNA.
DR   EMBL; BX640448; CAE35867.1; -; Genomic_DNA.
DR   PIR; JC4556; JC4556.
DR   RefSeq; WP_010926977.1; NC_002927.3.
DR   AlphaFoldDB; Q44740; -.
DR   SMR; Q44740; -.
DR   STRING; 257310.BB3893; -.
DR   EnsemblBacteria; CAE35867; CAE35867; BB3893.
DR   GeneID; 56477621; -.
DR   KEGG; bbr:BB3893; -.
DR   eggNOG; COG3486; Bacteria.
DR   HOGENOM; CLU_020931_0_0_4; -.
DR   OMA; FYIRESF; -.
DR   OrthoDB; 324612at2; -.
DR   BioCyc; MetaCyc:MON-15213; -.
DR   UniPathway; UPA00023; -.
DR   Proteomes; UP000001027; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR025700; Lys/Orn_oxygenase.
DR   PANTHER; PTHR42802; PTHR42802; 1.
DR   Pfam; PF13434; K_oxygenase; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; NADP; Oxidoreductase.
FT   CHAIN           1..461
FT                   /note="Alcaligin biosynthesis enzyme"
FT                   /id="PRO_0000204031"
FT   BINDING         9..15
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        445
FT                   /note="G -> R (in Ref. 1; AAA97596/AAB40618)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   461 AA;  52927 MW;  5A2FB50A1A27605F CRC64;
     MNREIYDFVA IGIGPFNLSL ASLSAPLRGV RTLFLDKKSG FDWHPGMLIE TSTLQNPFLA
     DLVSLADPRS EYSYLNYCKL TNRIYSYYMR ENHYLSRAEY TRYCQWVAAR LPNLRFGCDV
     QGVLHDPESH SYLVTGQHTM SGQRFMFRCR KLVLGLGSQP YLPACCDRRA APFIHSADYL
     RHKYELQGRA SITIVGSGQS AAEVFHDLLR ESGRHDYSLA WITRSPRFFQ MENTKLTLEL
     ISPDYTEYFH DLPEARRQEI LTQQNSLYKG INASLINQIY DLLDEKVHDG DNRYTLLTNS
     ELRACRYDPL QERFQLDFQH LDCDRPFSHA TDGLVLATGY SHEIPACINP IHDRIAWNAD
     GSYRIGRNYA IDHEGSEIFV QNTGLLSHGV TNPDLGFCCY RNSQILRELT GTEHYRIETR
     TALQEFSPPA DGVLKHRPAR RAERGPTVAA RPLMDIHRAT L