ID   ALCA_BORPE              Reviewed;         461 AA.
AC   P65199; P59855;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Alcaligin biosynthesis enzyme;
DE            EC=1.-.-.-;
GN   Name=alcA; OrderedLocusNames=BP2456;
OS   Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- PATHWAY: Siderophore biosynthesis; alcaligin biosynthesis.
CC   -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC       oxygenase family. {ECO:0000305}.
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DR   EMBL; BX640418; CAE42728.1; -; Genomic_DNA.
DR   RefSeq; NP_881083.1; NC_002929.2.
DR   RefSeq; WP_003814013.1; NZ_CP039022.1.
DR   AlphaFoldDB; P65199; -.
DR   SMR; P65199; -.
DR   STRING; 257313.BP2456; -.
DR   GeneID; 56624947; -.
DR   KEGG; bpe:BP2456; -.
DR   PATRIC; fig|257313.5.peg.2647; -.
DR   eggNOG; COG3486; Bacteria.
DR   HOGENOM; CLU_020931_0_0_4; -.
DR   OMA; FYIRESF; -.
DR   UniPathway; UPA00023; -.
DR   PRO; PR:P65199; -.
DR   Proteomes; UP000002676; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR025700; Lys/Orn_oxygenase.
DR   PANTHER; PTHR42802; PTHR42802; 1.
DR   Pfam; PF13434; K_oxygenase; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..461
FT                   /note="Alcaligin biosynthesis enzyme"
FT                   /id="PRO_0000204032"
FT   BINDING         9..15
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   461 AA;  53026 MW;  412E050A1A27605F CRC64;
     MNREIYDFVA IGIGPFNLSL ASLSAPLRGV RTLFLDKKSG FDWHPGMLIE TSTLQNPFLA
     DLVSLADPRS EYSYLNYCKL TNRIYSYYMR ENHYLSRAEY TRYCQWVAAR LPNLRFGCDV
     QGVLHDPESH SYLVTGQHTM SGQRFMFRCR KLVLGLGSQP YLPACCDRRA APFIHSADYL
     RHKYELQGRA SITIVGSGQS AAEVFHDLLR ESGRHDYSLA WITRSPRFFQ MENTKLTLEL
     ISPDYTEYFH DLPEARRQEI LTQQNSLYKG INASLINQIY DLLDEKVHDG DNRYTLLTNS
     ELRACRYDPL QERFQLDFQH LDCDRPFSHA TDGLVLATGY SHEIPACINP IHDRIAWNAD
     GSYRIGRNYA IDHEGSEIFV QNTGLLSHGV TNPDLGFCCY RNSQILRELT GTEHYRIETR
     TALQEFSPPA DGVLKHRPAR RAERRPTVAA RPLMDIHRAT L