ID   ALCS_ASPFU              Reviewed;         272 AA.
AC   Q24JP1; Q4WAE2;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Protein alcS;
GN   Name=alcS {ECO:0000312|EMBL:DAA05752.1}; ORFNames=AFUA_7G00990;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1] {ECO:0000312|EMBL:EAL84794.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2] {ECO:0000312|EMBL:DAA05752.1}
RP   IDENTIFICATION.
RX   PubMed=16531087; DOI=10.1016/j.fgb.2005.12.008;
RA   Flipphi M., Robellet X., Dequier E., Leschelle X., Felenbok B., Velot C.;
RT   "Functional analysis of alcS, a gene of the alc cluster in Aspergillus
RT   nidulans.";
RL   Fungal Genet. Biol. 43:247-260(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC       septum {ECO:0000250|UniProtKB:Q460G9, ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the acetate uptake transporter (AceTr) (TC
CC       2.A.96) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL84794.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AAHF01000015; EAL84794.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; BK005755; DAA05752.1; -; Genomic_DNA.
DR   RefSeq; XP_746832.2; XM_741739.2.
DR   AlphaFoldDB; Q24JP1; -.
DR   SMR; Q24JP1; -.
DR   GeneID; 3504140; -.
DR   KEGG; afm:AFUA_7G00990; -.
DR   eggNOG; ENOG502S179; Eukaryota.
DR   HOGENOM; CLU_051062_4_0_1; -.
DR   InParanoid; Q24JP1; -.
DR   OrthoDB; 1251190at2759; -.
DR   Proteomes; UP000002530; Chromosome 7.
DR   GO; GO:0030428; C:cell septum; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015123; F:acetate transmembrane transporter activity; IBA:GO_Central.
DR   InterPro; IPR030186; AlcS/PatA.
DR   InterPro; IPR000791; Gpr1/Fun34/SatP.
DR   PANTHER; PTHR31123:SF4; PTHR31123:SF4; 1.
DR   Pfam; PF01184; Gpr1_Fun34_YaaH; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..272
FT                   /note="Protein alcS"
FT                   /id="PRO_0000393863"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   272 AA;  29038 MW;  2F852706A0DC3B66 CRC64;
     MDTEQGLKNH TAKTSPHDET AMASLTTIPT SVTLSAEQFE KLYLSPLTQR QGMLSKQMGN
     PTPLALGGFV ITTTPLSCCL MGWRGATGSG IAFTGPIIFL GGGLLVLTSI LEFILGNTFP
     CVVFGTIGAF WFAFGCTMTP AFNAAAPFST SATDTVAGLS SPDFLNTYAF LFIWMGVLML
     IFLACATRTN AVYVAIFTTL TLVFGFLSGA YWRLAVADAL VGNRLVVAAG ACLFVASMLG
     FYLLVAQLFD SVGLPVRLPV GDLSRFWDRR AR