ALC_ARATH
ID ALC_ARATH Reviewed; 210 AA.
AC Q9FHA2; A8MRE6; A8MS60;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transcription factor ALC;
DE AltName: Full=Basic helix-loop-helix protein 73;
DE Short=AtbHLH73;
DE Short=bHLH 73;
DE AltName: Full=Protein ALCATRAZ;
DE AltName: Full=Transcription factor EN 98;
DE AltName: Full=bHLH transcription factor bHLH073;
GN Name=ALC; Synonyms=BHLH73, EN98; OrderedLocusNames=At5g67110;
GN ORFNames=K21H1.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 115-210 (ISOFORMS 1/2), TISSUE SPECIFICITY,
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=11747817; DOI=10.1016/s0960-9822(01)00593-0;
RA Rajani S., Sundaresan V.;
RT "The Arabidopsis myc/bHLH gene ALCATRAZ enables cell separation in fruit
RT dehiscence.";
RL Curr. Biol. 11:1914-1922(2001).
RN [6]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- FUNCTION: Required for the dehiscence of fruit, especially for the
CC separation of the valve cells from the replum. Promotes the
CC differentiation of a strip of labile nonlignified cells sandwiched
CC between layers of lignified cells. {ECO:0000269|PubMed:11747817}.
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9FHA2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9FHA2-2; Sequence=VSP_036108;
CC Name=3;
CC IsoId=Q9FHA2-3; Sequence=VSP_036109;
CC -!- TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems,
CC and flowers. Confined to the valve margins of the silique.
CC {ECO:0000269|PubMed:11747817, ECO:0000269|PubMed:12679534}.
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DR EMBL; AB020742; BAB10945.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98301.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98302.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98303.1; -; Genomic_DNA.
DR EMBL; BT028946; ABI49493.1; -; mRNA.
DR EMBL; AF488605; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001078810.1; NM_001085341.1. [Q9FHA2-3]
DR RefSeq; NP_001078811.1; NM_001085342.1. [Q9FHA2-2]
DR RefSeq; NP_201512.1; NM_126111.4. [Q9FHA2-1]
DR AlphaFoldDB; Q9FHA2; -.
DR SMR; Q9FHA2; -.
DR BioGRID; 22088; 16.
DR IntAct; Q9FHA2; 11.
DR STRING; 3702.AT5G67110.1; -.
DR PaxDb; Q9FHA2; -.
DR PRIDE; Q9FHA2; -.
DR ProteomicsDB; 245015; -. [Q9FHA2-1]
DR EnsemblPlants; AT5G67110.1; AT5G67110.1; AT5G67110. [Q9FHA2-1]
DR EnsemblPlants; AT5G67110.2; AT5G67110.2; AT5G67110. [Q9FHA2-3]
DR EnsemblPlants; AT5G67110.3; AT5G67110.3; AT5G67110. [Q9FHA2-2]
DR GeneID; 836846; -.
DR Gramene; AT5G67110.1; AT5G67110.1; AT5G67110. [Q9FHA2-1]
DR Gramene; AT5G67110.2; AT5G67110.2; AT5G67110. [Q9FHA2-3]
DR Gramene; AT5G67110.3; AT5G67110.3; AT5G67110. [Q9FHA2-2]
DR KEGG; ath:AT5G67110; -.
DR Araport; AT5G67110; -.
DR TAIR; locus:2155503; AT5G67110.
DR eggNOG; ENOG502QVNY; Eukaryota.
DR HOGENOM; CLU_1333564_0_0_1; -.
DR InParanoid; Q9FHA2; -.
DR OMA; NKRNGAK; -.
DR OrthoDB; 1376203at2759; -.
DR PhylomeDB; Q9FHA2; -.
DR PRO; PR:Q9FHA2; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FHA2; baseline and differential.
DR Genevisible; Q9FHA2; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0010047; P:fruit dehiscence; IMP:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR031066; bHLH_ALC-like_plant.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR45855; PTHR45855; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..210
FT /note="Transcription factor ALC"
FT /id="PRO_0000358839"
FT DOMAIN 93..142
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 104..125
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_036108"
FT VAR_SEQ 126..210
FT /note="TDKASMLDEAIEYLKQLQLQVQTLAVMNGLGLNPMRLPQVPPPTHTRINETL
FT EQDLNLETLLAAPHSLEPAKTSQGMCFSTATLL -> VNQSLFESEIVRNIVLIDPLSF
FT VCL (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_036109"
SQ SEQUENCE 210 AA; 22963 MW; CE5287FB7314223D CRC64;
MGDSDVGDRL PPPSSSDELS SFLRQILSRT PTAQPSSPPK STNVSSAETF FPSVSGGAVS
SVGYGVSETG QDKYAFEHKR SGAKQRNSLK RNIDAQFHNL SEKKRRSKIN EKMKALQKLI
PNSNKTDKAS MLDEAIEYLK QLQLQVQTLA VMNGLGLNPM RLPQVPPPTH TRINETLEQD
LNLETLLAAP HSLEPAKTSQ GMCFSTATLL
