FPTA_PSEAE
ID FPTA_PSEAE Reviewed; 720 AA.
AC P42512;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Fe(3+)-pyochelin receptor;
DE AltName: Full=Fe(III)-pyochelin receptor;
DE Flags: Precursor;
GN Name=fptA; OrderedLocusNames=PA4221;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 39-51.
RC STRAIN=PAO / IA602;
RX PubMed=8288523; DOI=10.1128/jb.176.2.307-319.1994;
RA Ankenbauer R.G., Quan H.N.;
RT "FptA, the Fe(III)-pyochelin receptor of Pseudomonas aeruginosa: a
RT phenolate siderophore receptor homologous to hydroxamate siderophore
RT receptors.";
RL J. Bacteriol. 176:307-319(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: High-affinity outer membrane receptor required for the
CC transport of Fe(3+)-pyochelin.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC {ECO:0000305}.
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DR EMBL; U03161; AAC43213.1; -; Unassigned_DNA.
DR EMBL; AE004091; AAG07609.1; -; Genomic_DNA.
DR PIR; A36942; A36942.
DR RefSeq; NP_252911.1; NC_002516.2.
DR RefSeq; WP_003111969.1; NZ_QZGE01000042.1.
DR PDB; 1XKW; X-ray; 2.00 A; A=56-720.
DR PDBsum; 1XKW; -.
DR AlphaFoldDB; P42512; -.
DR SMR; P42512; -.
DR STRING; 287.DR97_3690; -.
DR BindingDB; P42512; -.
DR ChEMBL; CHEMBL3097981; -.
DR DrugBank; DB04147; Dodecyldimethylamine N-oxide.
DR TCDB; 1.B.14.1.8; the outer membrane receptor (omr) family.
DR PaxDb; P42512; -.
DR PRIDE; P42512; -.
DR EnsemblBacteria; AAG07609; AAG07609; PA4221.
DR GeneID; 880419; -.
DR KEGG; pae:PA4221; -.
DR PATRIC; fig|208964.12.peg.4422; -.
DR PseudoCAP; PA4221; -.
DR HOGENOM; CLU_008287_9_3_6; -.
DR InParanoid; P42512; -.
DR OMA; NAHYEND; -.
DR PhylomeDB; P42512; -.
DR BioCyc; PAER208964:G1FZ6-4294-MON; -.
DR EvolutionaryTrace; P42512; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IDA:CAFA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:1903981; F:enterobactin binding; IDA:CAFA.
DR GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR DisProt; DP00176; -.
DR Gene3D; 2.170.130.10; -; 1.
DR Gene3D; 2.40.170.20; -; 1.
DR InterPro; IPR012910; Plug_dom.
DR InterPro; IPR037066; Plug_dom_sf.
DR InterPro; IPR039423; TonB-dep_rcpt.
DR InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR InterPro; IPR010917; TonB_rcpt_CS.
DR InterPro; IPR010105; TonB_sidphr_rcpt.
DR PANTHER; PTHR32552; PTHR32552; 1.
DR Pfam; PF07715; Plug; 1.
DR Pfam; PF00593; TonB_dep_Rec; 1.
DR TIGRFAMs; TIGR01783; TonB-siderophor; 1.
DR PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Direct protein sequencing;
KW Ion transport; Iron; Iron transport; Membrane; Receptor;
KW Reference proteome; Signal; TonB box; Transmembrane;
KW Transmembrane beta strand; Transport.
FT SIGNAL 1..38
FT /evidence="ECO:0000269|PubMed:8288523"
FT CHAIN 39..720
FT /note="Fe(3+)-pyochelin receptor"
FT /id="PRO_0000034750"
FT MOTIF 703..720
FT /note="TonB C-terminal box"
FT HELIX 76..78
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 80..87
FT /evidence="ECO:0007829|PDB:1XKW"
FT HELIX 88..93
FT /evidence="ECO:0007829|PDB:1XKW"
FT HELIX 99..104
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 109..115
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 118..123
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 130..133
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 153..161
FT /evidence="ECO:0007829|PDB:1XKW"
FT TURN 164..167
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 172..180
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 188..196
FT /evidence="ECO:0007829|PDB:1XKW"
FT TURN 197..199
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 200..229
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 231..234
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 236..251
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 254..268
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 297..314
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 317..339
FT /evidence="ECO:0007829|PDB:1XKW"
FT TURN 343..345
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 349..375
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 378..398
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 400..402
FT /evidence="ECO:0007829|PDB:1XKW"
FT TURN 410..412
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 415..417
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 432..448
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 451..465
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 476..488
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 491..502
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 518..531
FT /evidence="ECO:0007829|PDB:1XKW"
FT HELIX 532..534
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 536..553
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 555..557
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 566..586
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 589..604
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 620..630
FT /evidence="ECO:0007829|PDB:1XKW"
FT HELIX 633..636
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 638..647
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 650..654
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 657..661
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 664..687
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 694..696
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 704..706
FT /evidence="ECO:0007829|PDB:1XKW"
FT STRAND 711..720
FT /evidence="ECO:0007829|PDB:1XKW"
SQ SEQUENCE 720 AA; 79992 MW; DA796313116E0CC2 CRC64;
MKTETKVIKG RQGIARNRHT PLCLGLLLAL SPLAAAVADA RKDGETELPD MVISGESTSA
TQPPGVTTLG KVPLKPRELP QSASVIDHER LEQQNLFSLD EAMQQATGVT VQPFQLLTTA
YYVRGFKVDS FELDGVPALL GNTASSPQDM AIYERVEILR GSNGLLHGTG NPAATVNLVR
KRPQREFAAS TTLSAGRWDR YRAEVDVGGP LSASGNVRGR AVAAYEDRDY FYDVADQGTR
LLYGVTEFDL SPDTLLTVGA QYQHIDSITN MAGVPMAKDG SNLGLSRDTY LDVDWDRFKW
DTYRAFGSLE QQLGGGWKGK VSAEYQEADS RLRYAGSFGA IDPQTGDGGQ LMGAAYKFKS
IQRSLDANLN GPVRLFGLTH ELLGGVTYAQ GETRQDTARF LNLPNTPVNV YRWDPHGVPR
PQIGQYTSPG TTTTTQKGLY ALGRIKLAEP LTLVVGGRES WWDQDTPATR FKPGRQFTPY
GGLIWDFARD WSWYVSYAEV YQPQADRQTW NSEPLSPVEG KTYETGIKGE LADGRLNLSL
AAFRIDLENN PQEDPDHPGP PNNPFYISGG KVRSQGFELE GTGYLTPYWS LSAGYTYTST
EYLKDSQNDS GTRYSTFTPR HLLRLWSNYD LPWQDRRWSV GGGLQAQSDY SVDYRGVSMR
QGGYALVNMR LGYKIDEHWT AAVNVNNLFD RTYYQSLSNP NWNNRYGEPR SFNVSLRGAF
