FPVA_PSEAE
ID FPVA_PSEAE Reviewed; 815 AA.
AC P48632; Q51339;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 08-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Ferripyoverdine receptor;
DE Flags: Precursor;
GN Name=fpvA; OrderedLocusNames=PA2398;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 44-64.
RC STRAIN=CD10;
RX PubMed=8335619; DOI=10.1128/jb.175.15.4597-4604.1993;
RA Poole K., Neshat S., Krebes K., Heinrichs D.E.;
RT "Cloning and nucleotide sequence analysis of the ferripyoverdine receptor
RT gene fpvA of Pseudomonas aeruginosa.";
RL J. Bacteriol. 175:4597-4604(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-49.
RC STRAIN=PAO;
RX PubMed=8918232; DOI=10.1016/0378-1119(96)00209-0;
RA McMorran B.J., Merriman M.E., Rombel I.T., Lamont I.L.;
RT "Characterisation of the pvdE gene which is required for pyoverdine
RT synthesis in Pseudomonas aeruginosa.";
RL Gene 176:55-59(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Receptor for the siderophore ferripyoverdine.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC -!- INDUCTION: By the siderophore, pyoverdine, and under iron starvation
CC conditions.
CC -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-16 is the initiator.
CC {ECO:0000305}.
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DR EMBL; L10210; AAA25819.1; -; Genomic_DNA.
DR EMBL; U07359; AAB60199.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG05786.1; -; Genomic_DNA.
DR PIR; A40601; A40601.
DR PIR; H83345; H83345.
DR RefSeq; NP_251088.1; NC_002516.2.
DR RefSeq; WP_004349900.1; NZ_QZGE01000021.1.
DR PDB; 1XKH; X-ray; 3.60 A; A/B/C=129-815.
DR PDB; 2IAH; X-ray; 2.73 A; A=44-815.
DR PDB; 2O5P; X-ray; 2.77 A; A/B=44-815.
DR PDB; 2W16; X-ray; 2.71 A; A/B=44-815.
DR PDB; 2W6T; X-ray; 2.90 A; A/B=44-815.
DR PDB; 2W6U; X-ray; 3.00 A; A/B=44-815.
DR PDB; 2W75; X-ray; 2.90 A; A/B=44-815.
DR PDB; 2W76; X-ray; 2.80 A; A/B=44-815.
DR PDB; 2W77; X-ray; 2.90 A; A/B=44-815.
DR PDB; 2W78; X-ray; 3.00 A; A/B=44-815.
DR PDB; 5ODW; X-ray; 2.80 A; A/B=1-815.
DR PDBsum; 1XKH; -.
DR PDBsum; 2IAH; -.
DR PDBsum; 2O5P; -.
DR PDBsum; 2W16; -.
DR PDBsum; 2W6T; -.
DR PDBsum; 2W6U; -.
DR PDBsum; 2W75; -.
DR PDBsum; 2W76; -.
DR PDBsum; 2W77; -.
DR PDBsum; 2W78; -.
DR PDBsum; 5ODW; -.
DR AlphaFoldDB; P48632; -.
DR SMR; P48632; -.
DR STRING; 208964.PA2398; -.
DR DrugBank; DB08249; 3,6,9,12,15-PENTAOXATRICOSAN-1-OL.
DR TCDB; 1.B.14.1.6; the outer membrane receptor (omr) family.
DR PaxDb; P48632; -.
DR PRIDE; P48632; -.
DR EnsemblBacteria; AAG05786; AAG05786; PA2398.
DR GeneID; 878605; -.
DR KEGG; pae:PA2398; -.
DR PATRIC; fig|208964.12.peg.2509; -.
DR PseudoCAP; PA2398; -.
DR HOGENOM; CLU_008287_9_3_6; -.
DR InParanoid; P48632; -.
DR OMA; RATYSHK; -.
DR PhylomeDB; P48632; -.
DR BioCyc; PAER208964:G1FZ6-2436-MON; -.
DR EvolutionaryTrace; P48632; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IDA:CAFA.
DR GO; GO:0016021; C:integral component of membrane; IDA:CAFA.
DR GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IDA:PseudoCAP.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0002049; P:pyoverdine biosynthetic process; IMP:PseudoCAP.
DR Gene3D; 2.170.130.10; -; 1.
DR Gene3D; 2.40.170.20; -; 1.
DR InterPro; IPR012910; Plug_dom.
DR InterPro; IPR037066; Plug_dom_sf.
DR InterPro; IPR011662; Secretin/TonB_short_N.
DR InterPro; IPR039423; TonB-dep_rcpt.
DR InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR InterPro; IPR010917; TonB_rcpt_CS.
DR InterPro; IPR010105; TonB_sidphr_rcpt.
DR PANTHER; PTHR32552; PTHR32552; 1.
DR Pfam; PF07715; Plug; 1.
DR Pfam; PF07660; STN; 1.
DR Pfam; PF00593; TonB_dep_Rec; 1.
DR SMART; SM00965; STN; 1.
DR TIGRFAMs; TIGR01783; TonB-siderophor; 1.
DR PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Direct protein sequencing;
KW Ion transport; Iron; Iron transport; Membrane; Receptor;
KW Reference proteome; Signal; TonB box; Transmembrane;
KW Transmembrane beta strand; Transport.
FT SIGNAL 1..43
FT /evidence="ECO:0000255"
FT CHAIN 44..815
FT /note="Ferripyoverdine receptor"
FT /id="PRO_0000034751"
FT MOTIF 798..815
FT /note="TonB C-terminal box"
FT CONFLICT 716
FT /note="Y -> F (in Ref. 1; AAA25819)"
FT /evidence="ECO:0000305"
FT CONFLICT 745..746
FT /note="Missing (in Ref. 1; AAA25819)"
FT /evidence="ECO:0000305"
FT CONFLICT 750
FT /note="S -> R (in Ref. 1; AAA25819)"
FT /evidence="ECO:0000305"
FT STRAND 46..50
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 52..54
FT /evidence="ECO:0007829|PDB:2IAH"
FT HELIX 55..65
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 69..72
FT /evidence="ECO:0007829|PDB:2W16"
FT HELIX 74..77
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 85..89
FT /evidence="ECO:0007829|PDB:2W16"
FT HELIX 91..99
FT /evidence="ECO:0007829|PDB:2W16"
FT TURN 100..103
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 105..109
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 112..116
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 132..134
FT /evidence="ECO:0007829|PDB:2W16"
FT TURN 154..156
FT /evidence="ECO:0007829|PDB:2W16"
FT HELIX 162..164
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 166..172
FT /evidence="ECO:0007829|PDB:2W16"
FT HELIX 174..180
FT /evidence="ECO:0007829|PDB:2W16"
FT HELIX 185..190
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 196..201
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 204..209
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 217..219
FT /evidence="ECO:0007829|PDB:2W16"
FT TURN 229..237
FT /evidence="ECO:0007829|PDB:2W16"
FT HELIX 240..242
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 243..251
FT /evidence="ECO:0007829|PDB:2W16"
FT HELIX 254..257
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 262..270
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 278..286
FT /evidence="ECO:0007829|PDB:2W16"
FT TURN 287..289
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 290..302
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 306..318
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 326..341
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 344..359
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 362..369
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 392..406
FT /evidence="ECO:0007829|PDB:2W16"
FT TURN 407..409
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 410..430
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 441..466
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 468..490
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 499..501
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 519..538
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 540..560
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 563..578
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 580..594
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 611..624
FT /evidence="ECO:0007829|PDB:2W16"
FT HELIX 625..627
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 629..645
FT /evidence="ECO:0007829|PDB:2W16"
FT HELIX 648..651
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 664..682
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 685..698
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 699..701
FT /evidence="ECO:0007829|PDB:2IAH"
FT STRAND 710..720
FT /evidence="ECO:0007829|PDB:2W16"
FT HELIX 723..725
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 728..737
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 740..746
FT /evidence="ECO:0007829|PDB:2W16"
FT TURN 747..750
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 751..757
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 760..772
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 775..783
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 790..793
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 797..801
FT /evidence="ECO:0007829|PDB:2W16"
FT STRAND 805..814
FT /evidence="ECO:0007829|PDB:2W16"
SQ SEQUENCE 815 AA; 91167 MW; A11AE4AA5A290F35 CRC64;
MPAPHGLSPL SKAFLMRRAF QRRILPHSLA MALSLPLAGY VQAQEVEFDI PPQALGSALQ
EFGRQADIQV LYRPEEVRNK RSSAIKGKLE PNQAITELLR GTGASVDFQG NAITISVAEA
ADSSVDLGAT MITSNQLGTI TEDSGSYTPG TIATATRLVL TPRETPQSIT VVTRQNMDDF
GLNNIDDVMR HTPGITVSAY DTDRNNYYAR GFSINNFQYD GIPSTARNVG YSAGNTLSDM
AIYDRVEVLK GATGLLTGAG SLGATINLIR KKPTHEFKGH VELGAGSWDN YRSELDVSGP
LTESGNVRGR AVAAYQDKHS FMDHYERKTS VYYGILEFDL NPDTMLTVGA DYQDNDPKGS
GWSGSFPLFD SQGNRNDVSR SFNNGAKWSS WEQYTRTVFA NLEHNFANGW VGKVQLDHKI
NGYHAPLGAI MGDWPAPDNS AKIVAQKYTG ETKSNSLDIY LTGPFQFLGR EHELVVGTSA
SFSHWEGKSY WNLRNYDNTT DDFINWDGDI GKPDWGTPSQ YIDDKTRQLG SYMTARFNVT
DDLNLFLGGR VVDYRVTGLN PTIRESGRFI PYVGAVYDLN DTYSVYASYT DIFMPQDSWY
RDSSNKLLEP DEGQNYEIGI KGEYLDGRLN TSLAYFEIHE ENRAEEDALY NSKPTNPAIT
YAYKGIKAKT KGYEAEISGE LAPGWQVQAG YTHKIIRDDS GKKVSTWEPQ DQLSLYTSYK
FKGALDKLTV GGGARWQGKS WQMVYNNPRS RWEKFSQEDY WLVDLMARYQ ITDKLSASVN
VNNVFDKTYY TNIGFYTSAS YGDPRNLMFS TRWDF
