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FRA13_FRAAN
ID   FRA13_FRAAN             Reviewed;         159 AA.
AC   D0E0C7;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Major strawberry allergen Fra a 1-3 {ECO:0000305};
DE   AltName: Full=Class 10 plant pathogenesis-related protein Fra a 1.03 {ECO:0000305};
DE            Short=PR10-related protein Fra a 1.03 {ECO:0000305};
DE   AltName: Allergen=Fra a 1 {ECO:0000305};
GN   Name=FRAA3 {ECO:0000303|PubMed:19969523};
OS   Fragaria ananassa (Strawberry) (Fragaria chiloensis x Fragaria virginiana).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Rosoideae; Potentilleae; Fragariinae;
OC   Fragaria.
OX   NCBI_TaxID=3747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=19969523; DOI=10.1093/mp/ssp087;
RA   Munoz C., Hoffmann T., Escobar N.M., Ludemann F., Botella M.A.,
RA   Valpuesta V., Schwab W.;
RT   "The strawberry fruit Fra a allergen functions in flavonoid biosynthesis.";
RL   Mol. Plant 3:113-124(2010).
RN   [2]
RP   ALLERGEN.
RX   PubMed=27086707; DOI=10.1021/acs.jafc.6b00488;
RA   Franz-Oberdorf K., Eberlein B., Edelmann K., Huecherig S., Besbes F.,
RA   Darsow U., Ring J., Schwab W.;
RT   "Fra a 1.02 is the most potent isoform of the Bet v 1-like allergen in
RT   strawberry fruit.";
RL   J. Agric. Food Chem. 64:3688-3696(2016).
RN   [3]
RP   INTERACTION WITH AP.
RX   PubMed=28656626; DOI=10.1002/prot.25343;
RA   Franz-Oberdorf K., Langer A., Strasser R., Isono E., Ranftl Q.L.,
RA   Wunschel C., Schwab W.;
RT   "Physical interaction between the strawberry allergen Fra a 1 and an
RT   associated partner FaAP: Interaction of Fra a 1 proteins and FaAP.";
RL   Proteins 85:1891-1901(2017).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 2-159 IN COMPLEX WITH
RP   (+)-CATECHIN, AND SUBUNIT.
RX   PubMed=24133217; DOI=10.1074/jbc.m113.501528;
RA   Casanal A., Zander U., Munoz C., Dupeux F., Luque I., Botella M.A.,
RA   Schwab W., Valpuesta V., Marquez J.A.;
RT   "The strawberry pathogenesis-related 10 (PR-10) Fra a proteins control
RT   flavonoid biosynthesis by binding to metabolic intermediates.";
RL   J. Biol. Chem. 288:35322-35332(2013).
CC   -!- FUNCTION: Involved in the control of flavonoid biosynthesis in fruits,
CC       probably by binding directly to natural flavonoids (PubMed:19969523).
CC       Binds the natural flavonoid catechin with affinities in the low
CC       micromolar range (PubMed:24133217). {ECO:0000269|PubMed:19969523,
CC       ECO:0000269|PubMed:24133217}.
CC   -!- SUBUNIT: Monomer (PubMed:24133217). Interacts with AP
CC       (PubMed:28656626). {ECO:0000269|PubMed:24133217,
CC       ECO:0000269|PubMed:28656626}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in open flowers (PubMed:19969523).
CC       Expressed in roots, leaves and flower buds (PubMed:19969523). Expressed
CC       at low levels in ripe red fruits (PubMed:19969523).
CC       {ECO:0000269|PubMed:19969523}.
CC   -!- ALLERGEN: May cause an allergic reaction in human (PubMed:27086707).
CC       Binds to IgE of patients allergic to birch Bet v 1 (PubMed:27086707).
CC       Causes degranulation of basophils sensitized with IgE of patients
CC       allergic to birch Bet v 1 (PubMed:27086707).
CC       {ECO:0000269|PubMed:27086707}.
CC   -!- MISCELLANEOUS: Fruits silencing FRAA3 exhibit loss of pigmentation in
CC       mature fruits due to the lack of anthocyanin biosynthesis.
CC       {ECO:0000269|PubMed:19969523}.
CC   -!- SIMILARITY: Belongs to the BetVI family. {ECO:0000305}.
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DR   EMBL; GQ148819; ACX47058.1; -; mRNA.
DR   PDB; 4C94; X-ray; 3.00 A; A/B/C/D/E=2-159.
DR   PDBsum; 4C94; -.
DR   AlphaFoldDB; D0E0C7; -.
DR   SMR; D0E0C7; -.
DR   Allergome; 2124; Fra a 1.
DR   GO; GO:0010427; F:abscisic acid binding; IEA:InterPro.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR000916; Bet_v_I/MLP.
DR   InterPro; IPR024949; Bet_v_I_allergen.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   Pfam; PF00407; Bet_v_1; 1.
DR   PRINTS; PR00634; BETALLERGEN.
DR   PROSITE; PS00451; PATHOGENESIS_BETVI; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Allergen; Flavonoid biosynthesis;
KW   Pathogenesis-related protein; Plant defense.
FT   CHAIN           1..159
FT                   /note="Major strawberry allergen Fra a 1-3"
FT                   /id="PRO_0000447014"
FT   BINDING         70
FT                   /ligand="(2R,3S)-catechin"
FT                   /ligand_id="ChEBI:CHEBI:15600"
FT                   /evidence="ECO:0000269|PubMed:24133217,
FT                   ECO:0007744|PDB:4C94"
FT   STRAND          4..14
FT                   /evidence="ECO:0007829|PDB:4C94"
FT   HELIX           16..23
FT                   /evidence="ECO:0007829|PDB:4C94"
FT   HELIX           27..34
FT                   /evidence="ECO:0007829|PDB:4C94"
FT   TURN            36..38
FT                   /evidence="ECO:0007829|PDB:4C94"
FT   STRAND          39..50
FT                   /evidence="ECO:0007829|PDB:4C94"
FT   STRAND          54..59
FT                   /evidence="ECO:0007829|PDB:4C94"
FT   HELIX           61..63
FT                   /evidence="ECO:0007829|PDB:4C94"
FT   STRAND          67..76
FT                   /evidence="ECO:0007829|PDB:4C94"
FT   TURN            77..80
FT                   /evidence="ECO:0007829|PDB:4C94"
FT   STRAND          81..89
FT                   /evidence="ECO:0007829|PDB:4C94"
FT   STRAND          93..107
FT                   /evidence="ECO:0007829|PDB:4C94"
FT   STRAND          109..125
FT                   /evidence="ECO:0007829|PDB:4C94"
FT   HELIX           130..153
FT                   /evidence="ECO:0007829|PDB:4C94"
SQ   SEQUENCE   159 AA;  17449 MW;  8943E1B163B9CE86 CRC64;
     MGVFTYESEF TSVIPPPKLF KAFVLDADNL IPKIAPQAVK SAEIIEGDGG VGTIKKIHLG
     EGSEYSYVKH KIDGIDKDNF VYSYSIIEGD AIGDKIEKIS YEIKLVASGG GSIIKSTSHY
     HTKGEVEIKE EHVKAGKERA AGLFKIIENH LLAHPEEYN
 
 
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