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FRA18_FRAAN
ID   FRA18_FRAAN             Reviewed;         160 AA.
AC   A0A024B2V6;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   09-JUL-2014, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Major strawberry allergen Fra a 1.08 {ECO:0000305};
DE   AltName: Full=Class 10 plant pathogenesis-related protein Fra a 1.08 {ECO:0000305};
DE            Short=PR10-related protein Fra a 1.08 {ECO:0000305};
DE            EC=3.1.27.- {ECO:0000269|PubMed:30572279};
DE   AltName: Allergen=Fra a 1 {ECO:0000305};
GN   Name=Fra a 1.08 {ECO:0000303|PubMed:27086707};
OS   Fragaria ananassa (Strawberry) (Fragaria chiloensis x Fragaria virginiana).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Rosoideae; Potentilleae; Fragariinae;
OC   Fragaria.
OX   NCBI_TaxID=3747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX   PubMed=27086707; DOI=10.1021/acs.jafc.6b00488;
RA   Franz-Oberdorf K., Eberlein B., Edelmann K., Huecherig S., Besbes F.,
RA   Darsow U., Ring J., Schwab W.;
RT   "Fra a 1.02 is the most potent isoform of the Bet v 1-like allergen in
RT   strawberry fruit.";
RL   J. Agric. Food Chem. 64:3688-3696(2016).
RN   [2]
RP   FUNCTION, TISSUE SPECIFICITY, AND PHOSPHORYLATION.
RX   PubMed=30572279; DOI=10.1016/j.jplph.2018.12.002;
RA   Besbes F., Franz-Oberdorf K., Schwab W.;
RT   "Phosphorylation-dependent ribonuclease activity of Fra a 1 proteins.";
RL   J. Plant Physiol. 233:1-11(2019).
CC   -!- FUNCTION: Possesses ribonuclease activity in vitro.
CC       {ECO:0000269|PubMed:30572279}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in roots (PubMed:30572279).
CC       Expressed a low levels in ripe red fruits (PubMed:30572279).
CC       {ECO:0000269|PubMed:30572279}.
CC   -!- PTM: Phosphorylated in vivo. Phosphorylation prevents its activity as
CC       ribonuclease. {ECO:0000269|PubMed:30572279}.
CC   -!- ALLERGEN: May cause an allergic reaction in human (PubMed:27086707).
CC       Binds to IgE of patients allergic to birch Bet v 1 (PubMed:27086707).
CC       Causes degranulation of basophils sensitized with IgE of patients
CC       allergic to birch Bet v 1 (PubMed:27086707).
CC       {ECO:0000269|PubMed:27086707}.
CC   -!- SIMILARITY: Belongs to the BetVI family. {ECO:0000305}.
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DR   EMBL; KJ507739; AHZ10959.1; -; mRNA.
DR   AlphaFoldDB; A0A024B2V6; -.
DR   SMR; A0A024B2V6; -.
DR   GO; GO:0010427; F:abscisic acid binding; IEA:InterPro.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR000916; Bet_v_I/MLP.
DR   InterPro; IPR024949; Bet_v_I_allergen.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   Pfam; PF00407; Bet_v_1; 1.
DR   PRINTS; PR00634; BETALLERGEN.
DR   PROSITE; PS00451; PATHOGENESIS_BETVI; 1.
PE   1: Evidence at protein level;
KW   Allergen; Hydrolase; Nuclease; Pathogenesis-related protein;
KW   Phosphoprotein; Plant defense.
FT   CHAIN           1..160
FT                   /note="Major strawberry allergen Fra a 1.08"
FT                   /id="PRO_0000447019"
SQ   SEQUENCE   160 AA;  17525 MW;  202B4AEDFA0917F3 CRC64;
     MGVFTYETEF TSVIPPPRLY KAFVLDADNL IPKIAPQAVK SAEIVQGDGG VGTIKKIHLG
     EGSEYSYVKH QIDGLDKDNF VYNYSIIEGD AIGDKVEKIS YEIKLVASPS GGSIIKSTSH
     YHCKGEVEIK EEHVKAGKEK AAGLFKIIEN HLLANPEAYN
 
 
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