FRA1A_FRAAN
ID FRA1A_FRAAN Reviewed; 160 AA.
AC Q5ULZ4; A0A2Z6FJ89; Q3T923;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-MAY-2019, sequence version 3.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=Major strawberry allergen Fra a 1-A {ECO:0000303|PubMed:16945416};
DE AltName: Full=Fra a 1.01A {ECO:0000305};
DE AltName: Allergen=Fra a 1 {ECO:0000305};
GN Name=FRAA1A.1 {ECO:0000303|PubMed:16945416};
GN Synonyms=FRAA1A.2 {ECO:0000303|PubMed:16945416};
OS Fragaria ananassa (Strawberry) (Fragaria chiloensis x Fragaria virginiana).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Rosoideae; Potentilleae; Fragariinae;
OC Fragaria.
OX NCBI_TaxID=3747;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP ALLERGEN.
RX PubMed=16945416; DOI=10.1016/j.molimm.2006.06.004;
RA Musidlowska-Persson A., Alm R., Emanuelsson C.;
RT "Cloning and sequencing of the Bet v 1-homologous allergen Fra a 1 in
RT strawberry (Fragaria ananassa) shows the presence of an intron and little
RT variability in amino acid sequence.";
RL Mol. Immunol. 44:1245-1252(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=29177844; DOI=10.1007/s00299-017-2237-6;
RA Ishibashi M., Nabe T., Nitta Y., Tsuruta H., Iduhara M., Uno Y.;
RT "Analysis of major paralogs encoding the Fra a 1 allergen based on their
RT organ-specificity in Fragaria x ananassa.";
RL Plant Cell Rep. 37:411-424(2018).
RN [3]
RP PROTEIN SEQUENCE OF 22-69, AND ALLERGEN.
RX PubMed=15507096; DOI=10.1111/j.1398-9995.2004.00585.x;
RA Karlsson A.L., Alm R., Ekstrand B., Fjelkner-Modig S., Schioett A.,
RA Bengtsson U., Bjoerk L., Hjernoe K., Roepstorff P., Emanuelsson C.S.;
RT "Bet v 1 homologues in strawberry identified as IgE-binding proteins and
RT presumptive allergens.";
RL Allergy 59:1277-1284(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 87-160.
RC TISSUE=Receptacle;
RA Balogh A., Koncz T., Kiss E., Heszky L.E.;
RT "Identification of novel genes involved in ripening of strawberry fruits.";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in ripening of fruits. {ECO:0000305}.
CC -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q256S2}.
CC -!- ALLERGEN: May cause an allergic reaction in human (PubMed:15507096,
CC PubMed:16945416). Binds to IgE of patients allergic to strawberry,
CC birch Bet v 1 and apple Mal d 1 (PubMed:15507096, PubMed:16945416).
CC Causes degranulation of basophils sensitized with IgE of patients
CC allergic to strawberry, birch Bet v 1 and apple Mal d 1
CC (PubMed:15507096). {ECO:0000269|PubMed:15507096,
CC ECO:0000269|PubMed:16945416}.
CC -!- SIMILARITY: Belongs to the BetVI family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAV33460.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; DQ385511; ABD39049.1; -; Genomic_DNA.
DR EMBL; AM084674; CAJ29538.1; -; Genomic_DNA.
DR EMBL; LC214965; BBE27860.1; -; mRNA.
DR EMBL; AY679601; AAV33460.1; ALT_FRAME; mRNA.
DR AlphaFoldDB; Q5ULZ4; -.
DR SMR; Q5ULZ4; -.
DR Allergome; 11672; Fra a 1.0102.
DR Allergome; 2124; Fra a 1.
DR Allergome; 3286; Fra a 1.0101.
DR GO; GO:0010427; F:abscisic acid binding; IEA:InterPro.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009835; P:fruit ripening; IEA:UniProtKB-KW.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR000916; Bet_v_I/MLP.
DR InterPro; IPR024949; Bet_v_I_allergen.
DR InterPro; IPR023393; START-like_dom_sf.
DR Pfam; PF00407; Bet_v_1; 1.
DR PRINTS; PR00634; BETALLERGEN.
PE 1: Evidence at protein level;
KW Allergen; Direct protein sequencing; Fruit ripening;
KW Pathogenesis-related protein; Plant defense.
FT CHAIN 1..160
FT /note="Major strawberry allergen Fra a 1-A"
FT /id="PRO_0000154189"
FT CONFLICT 64
FT /note="H -> Q (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 73
FT /note="H -> N (in Ref. 2; BBE27860)"
FT /evidence="ECO:0000305"
FT CONFLICT 95..96
FT /note="NI -> TL (in Ref. 4; AAV33460)"
FT /evidence="ECO:0000305"
FT CONFLICT 110..114
FT /note="HGGTV -> SSSTI (in Ref. 4; AAV33460)"
FT /evidence="ECO:0000305"
FT CONFLICT 142
FT /note="S -> A (in Ref. 4; AAV33460)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 160 AA; 17784 MW; 636B0C12D7EE1689 CRC64;
MGVYTYENEF TSDIPAPKLF KAFVLDADNL IPKIAPQAVK CAEILEGDGG PGTIKKITFG
EGSHYGYVKH KIHSIDKENH TYSYSLIEGD ALSDNIEKID YETKLVSAPH GGTVIKTTSK
YHTKGDVEIK EEHVKAGKEK ASHLFKLIEG YLKDHPSEYN
