FRBI_BLOB1
ID FRBI_BLOB1 Reviewed; 15639 AA.
AC A0A0S6XHH0;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 17-FEB-2016, sequence version 1.
DT 03-AUG-2022, entry version 28.
DE RecName: Full=FR901469 synthetase {ECO:0000303|PubMed:27660098};
DE Short=NRPS frbI {ECO:0000303|PubMed:27660098};
DE EC=6.3.2.- {ECO:0000305|PubMed:27660098};
DE AltName: Full=FR901469 biosynthesis cluster protein I {ECO:0000303|PubMed:27660098};
DE AltName: Full=Nonribosomal peptide synthetase frbI;
GN Name=frbI {ECO:0000303|PubMed:27660098}; ORFNames=ANO11243_029940;
OS Fungal sp. (strain No.11243).
OC Eukaryota; Fungi.
OX NCBI_TaxID=1603295;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=25838475; DOI=10.1128/genomea.00118-15;
RA Matsui M., Yokoyama T., Nemoto K., Kumagai T., Terai G., Arita M.,
RA Machida M., Shibata T.;
RT "Genome sequence of fungal species No.11243, which produces the antifungal
RT antibiotic FR901469.";
RL Genome Announc. 3:0-0(2015).
RN [2]
RP BIOTECHNOLOGY.
RX PubMed=11099224; DOI=10.7164/antibiotics.53.912;
RA Fujie A., Iwamoto T., Muramatsu H., Okudaira T., Nitta K., Nakanishi T.,
RA Sakamoto K., Hori Y., Hino M., Hashimoto S., Okuhara M.;
RT "FR901469, a novel antifungal antibiotic from an unidentified fungus
RT No.11243. I. Taxonomy, fermentation, isolation, physico-chemical properties
RT and biological properties.";
RL J. Antibiot. 53:912-919(2000).
RN [3]
RP BIOTECHNOLOGY.
RX PubMed=11099225; DOI=10.7164/antibiotics.53.920;
RA Fujie A., Iwamoto T., Muramatsu H., Okudaira T., Sato I., Furuta T.,
RA Tsurumi Y., Hori Y., Hino M., Hashimoto S., Okuhara M.;
RT "FR901469, a novel antifungal antibiotic from an unidentified fungus
RT No.11243. II. In vitro and in vivo activities.";
RL J. Antibiot. 53:920-927(2000).
RN [4]
RP FUNCTION, DOMAIN, INDUCTION, AND PATHWAY.
RX PubMed=27660098; DOI=10.1016/j.jbiosc.2016.08.007;
RA Matsui M., Yokoyama T., Nemoto K., Kumagai T., Terai G., Tamano K.,
RA Machida M., Shibata T.;
RT "Identification of a putative FR901469 biosynthesis gene cluster in fungal
RT sp. No. 11243 and enhancement of the productivity by overexpressing the
RT transcription factor gene frbF.";
RL J. Biosci. Bioeng. 123:147-153(2017).
CC -!- FUNCTION: Nonribosomal peptide synthetase; part of the gene cluster
CC that mediates the biosynthesis of the antifungal antibiotic FR901469,
CC an inhibitor of beta-1,3-glucansynthase, exerting antifungal activity
CC against the pathogenes Candida albicans and Aspergillus fumigatus
CC (PubMed:27660098). FR901469 is a cyclic depsipeptide containing 12
CC amino acid residues and a fatty acid chain (PubMed:27660098). The NRPS
CC frbI contains 12 modules responsible for the formation of the
CC depsipeptide backbone which is denoted as Acyl-Thr-Ala-Tyr-Val-4OHPro-
CC Thr-Thr-3OHPro-threo3OHGln-Gly-Thr-Orn-OH (C71H116N14O23) (Probable).
CC The PKS frbB is probably involved in the production of the hydrocarbon
CC chain, and the acyl-CoA ligase frbC might be involved in the transport
CC of the chain to the peptide ptoduct of frbI (Probable). Because
CC FR901469 contains 3 hydroxylated amino acid residues, the 3 oxygenases
CC frbA, frbH, and frbJ might be participating in amino acid hydroxylation
CC (Probable). As no thioesterase domains were detected in frbI or frbB,
CC the thioesterases frbD and frbE may instead release and cyclize the
CC products of the NRPS and PKS, respectively (Probable).
CC {ECO:0000269|PubMed:27660098, ECO:0000305|PubMed:27660098}.
CC -!- PATHWAY: Antifungal biosynthesis. {ECO:0000305|PubMed:27660098}.
CC -!- INDUCTION: Expression is positively regulated by the cluster-specific
CC transcription factor frbF. {ECO:0000269|PubMed:27660098}.
CC -!- DOMAIN: NRP synthetases are composed of discrete domains (adenylation
CC (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation
CC (C) domains) which when grouped together are referred to as a single
CC module. Each module is responsible for the recognition (via the A
CC domain) and incorporation of a single amino acid into the growing
CC peptide product. Thus, an NRP synthetase is generally composed of one
CC or more modules and can terminate in a thioesterase domain (TE) that
CC releases the newly synthesized peptide from the enzyme. Occasionally,
CC epimerase (E) domains (responsible for L- to D-amino acid conversion)
CC are present within the NRP synthetase. FrbI has the following
CC architecture: T-C-A-T-E-C-A-T-E-C-A-T-C-A-T-C-A-T-C-A-T-E-C-A-T-C-A-T-
CC C-A-T-C-A-T-C-A-T-E-C-A-T-C. {ECO:0000305|PubMed:27660098}.
CC -!- BIOTECHNOLOGY: FR901469 inhibits the activity of 1,3-beta-glucan
CC synthase from Candida albicans and Aspergillus fumigatus
CC (PubMed:11099224, PubMed:11099225). With minimal inhibitory
CC concentrations (MICs) against Candida albicans and Aspergillus
CC fumigatus of 0.63 ug/ml and 0.16 ug/ml, repectively, FR901469 displays
CC greater inhibitory activity than other 1,3-beta-glucan synthase
CC inhibitors such as, WF11899A, echinocandin B, aculeacin A, and
CC papulacandin B (PubMed:11099224, PubMed:11099225).
CC {ECO:0000269|PubMed:11099224, ECO:0000269|PubMed:11099225}.
CC -!- SIMILARITY: Belongs to the NRP synthetase family. {ECO:0000305}.
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DR EMBL; DF938583; GAM84991.1; -; Genomic_DNA.
DR STRING; 1603295.A0A0S6XHH0; -.
DR OrthoDB; 4243at2759; -.
DR Proteomes; UP000054361; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR Gene3D; 1.10.1200.10; -; 13.
DR Gene3D; 3.30.300.30; -; 12.
DR Gene3D; 3.30.559.10; -; 17.
DR Gene3D; 3.40.50.12780; -; 12.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR Pfam; PF00501; AMP-binding; 12.
DR Pfam; PF00668; Condensation; 17.
DR Pfam; PF00550; PP-binding; 13.
DR SMART; SM00823; PKS_PP; 12.
DR SUPFAM; SSF47336; SSF47336; 13.
DR TIGRFAMs; TIGR01733; AA-adenyl-dom; 12.
DR PROSITE; PS00455; AMP_BINDING; 12.
DR PROSITE; PS50075; CARRIER; 13.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 8.
PE 1: Evidence at protein level;
KW Ligase; Phosphopantetheine; Phosphoprotein; Reference proteome.
FT CHAIN 1..15639
FT /note="FR901469 synthetase"
FT /id="PRO_0000454567"
FT DOMAIN 5..81
FT /note="Carrier 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT ECO:0000305|PubMed:27660098"
FT DOMAIN 1108..1184
FT /note="Carrier 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT ECO:0000305|PubMed:27660098"
FT DOMAIN 2654..2730
FT /note="Carrier 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT ECO:0000305|PubMed:27660098"
FT DOMAIN 4193..4269
FT /note="Carrier 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT ECO:0000305|PubMed:27660098"
FT DOMAIN 5284..5360
FT /note="Carrier 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT ECO:0000305|PubMed:27660098"
FT DOMAIN 6375..6451
FT /note="Carrier 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT ECO:0000305|PubMed:27660098"
FT DOMAIN 7473..7546
FT /note="Carrier 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT ECO:0000305|PubMed:27660098"
FT DOMAIN 9015..9091
FT /note="Carrier 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT ECO:0000305|PubMed:27660098"
FT DOMAIN 10110..10186
FT /note="Carrier 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT ECO:0000305|PubMed:27660098"
FT DOMAIN 11217..11293
FT /note="Carrier 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT ECO:0000305|PubMed:27660098"
FT DOMAIN 12298..12374
FT /note="Carrier 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT ECO:0000305|PubMed:27660098"
FT DOMAIN 13383..13459
FT /note="Carrier 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT ECO:0000305|PubMed:27660098"
FT DOMAIN 14916..14992
FT /note="Carrier 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT ECO:0000305|PubMed:27660098"
FT REGION 82..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..553
FT /note="Condensation 1"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 579..971
FT /note="Adenylation 1"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 1219..1626
FT /note="Epimerase 1"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 1667..2097
FT /note="Condensation 2"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 2122..2518
FT /note="Adenylation 2"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 2761..3176
FT /note="Epimerase 2"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 3215..3640
FT /note="Condensation 3"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 3669..4059
FT /note="Adenylation 3"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 4316..4714
FT /note="Condensation 4"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 4756..5149
FT /note="Adenylation 4"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 5402..5802
FT /note="Condensation 5"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 5847..6238
FT /note="Adenylation 5"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 6494..6889
FT /note="Condensation 6"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 6952..7335
FT /note="Adenylation 6"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 7580..7992
FT /note="Epimerase 3"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 8034..8459
FT /note="Condensation 7"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 8486..8882
FT /note="Adenylation 7"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 9136..9535
FT /note="Condensation 8"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 9583..9974
FT /note="Adenylation 8"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 10186..10208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10240..10662
FT /note="Condensation 9"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 10683..11082
FT /note="Adenylation 9"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 11329..11725
FT /note="Condensation 10"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 11770..12165
FT /note="Adenylation 10"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 12418..12830
FT /note="Condensation 11"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 12861..13249
FT /note="Adenylation 11"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 13476..13901
FT /note="Epimerase 4"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 13940..14369
FT /note="Condensation 12"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 14390..14789
FT /note="Adenylation 12"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 15062..15433
FT /note="Condensation 13"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:27660098"
FT REGION 15434..15511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 15617..15639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10187..10207
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15434..15472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15497..15511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 42
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 1145
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 2691
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 4230
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 5321
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 6412
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 7507
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 9052
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 10147
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 11254
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 12335
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 13420
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 14953
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
SQ SEQUENCE 15639 AA; 1711325 MW; EDFCE9379D8E28B0 CRC64;
MASEHTSDGL RKLLLDLALE VLEIEPTRFR PEKSFLELGG DSLSAIEFMA KCRANDIDVD
VGIILRAKNV ADLVDKIIEQ QLEEEEEDDD SLDNESERDH SQKDLMPSHL LELSDALLEK
VIKPTNVEAD LRAAIHCISP CLSMQEGCLI SHAIDPEAYQ CRFVLKITST NPTNLFNAEN
LAEAWRRVVA RHPSLRTSFM ESQNRPGKFD QIIWKSVRPQ ISICQDVSQV VAPTTPPKLD
YSQPPHHLVL AQGSAADLYV RLDISHAIVD GQSTEVLLHD LWQAYQGRLP QGEAIAVTDI
LKLHNSSTAA DAAAYWSDYL SKAQESYLPM KVNQAASTNL SSIKRTIKVA QDDLEAFCAK
RGVTIANLCQ MAWGLVLRSF TNSDKVCFSY VTSGRQVPLV GINEAVGAFI TTLIQRLDFN
RSKDIAEVLT QVNDDFIQSV PYQHLSFNDI GLKSARQWGN SILSMHRPLP TQVYANSGIG
FEPITRTTAT DYDVSLNIDI FTDSIVLNMD FWLSKMSEED AHSTLKVYEK AILFVLNNSD
KMTRDFLPLT EDDRATIHAR NQKIPSKVDK CVHDLVLETI SKQPDAVAVQ AWDGQWTYSE
LNEKATRVAE FLISLGTGPE VKVGLCMEKS RWAPIAMLGI LKAGGVVVPM GTQHPLSRVQ
TVLEDTKAIA ILTDKEQETR LGGLKVRKIT IDAEIMSNAN GSILANSTKV SPDNAAWIVY
TSGSTGTPKG VVLEHAALCS SITGHSAAFQ LDNKTRTLQF AAHTFDAAIQ DVFTTIFVGG
VICIPSEHDR MNALERVMDE LKVNFATLTS TVAGLLRPQA IPSMETIVLV GEAVKPAVVE
AWLPHSRVLN AYGPSECSIH STCSKPITDK RDALVIGFPL TDCLWVTDPD NYNRLSPIGA
SGELLIEGPI LARGYLNDLE KTGKAFVVDP DFVHELGLPK GRRMYRTGDL VRQNSDGSLT
YLGRRDTQVK IHGQRVEIGE IEYHITRHSS VEEAVVVKVS GGPMDGRLVG AIVLKNFVSG
TYHGTSVKEI DMGQHASAML QVSDVQLHLS ERVMQYMVPT FWIPVNSLPV NASGKIDRKV
VGTWMADLDM DTVERLSGTG EEEEKEQTPA TAIEKELRRI WSETLNIPLR NISYRNSFLS
LGGDSITAMQ VVSICRSVDI SVSVKQVLEC RALSELALVA RSTTESVDDL SVVPDGEFTL
APIQQQYFDL VAADGLEARS SNRFNQSVHL SVRRPIGVAE LARSMEAVVA KHAMLRARFV
PDTGSGWSQR IENQLVGSYR LKVSQVESME QVQSTIYDAQ DSLDLQNGPV FSADLISIKD
QQLVSMTAHH LVVDLVSWRI IVRDLEQLLS DRTLQNTRSL SFPTWLQLQR DHTEEKISES
TAALPFDVSP ADLKYWNLQP GTLTVKDRII EMIEVDELTT SLLFGAANNA MRSEPVEILL
AALFHSFANT FIDRPVPAIF NEGHGREPWS DELDLADTVG WFTTMTPLQV TNTTGDIVDT
LKQTKERRRR IPEKGMTAFA AQYFSGKSES QVMEILFNYE GRYQQLENED GLFRLAQPSD
LGDADQSLSV GQDVKIQAAI DINASVSSKK LQLRIGFSKQ SRRQDDMKQW MVACGETITH
LVKRLAHMAP MMTAGDFTTA TLTEDDVMFL EQTYLPEIGL NIPTDVEDVL PCTPIQQGIL
FSQENSKSTY KVRQLVEVLP RDASRPVSVD QLVKAWRTVI RQHSIMRTIF VDSLPNQQRF
HQVVLKEVDA VADIHILQNT QNRSLHDILA EQPEFDYRGK ERPPHRFTII TDISGKTFAH
FEISHALVDA SSIELLVSDL FAAYGGMPSG KASHYGEYVA FLESKPITDD LIYWKSLLEG
AEPCKLPLAS IDNATTTGSF TTRKHVGRQL TDLEELQTFR KEHEITIATL FQLAWSLVLK
SRTGSSKVSF GYLSSGRDVP IRDVEGLVGP MVNLMICHNH LDQDESVIAA ARKIQTKFLD
SFAHQRVPLD AIQHSLQLSG QALFNTTLSY KNSAASDSNA ASSISFNRLE AEDPTEYDIN
IDITAGKTDI AVTLQYSPET LAQSSADELL QQLVEIVQML CHNTETSLGN LSLLTNNDVT
SIKAWNAGPF LSDDRLLHHL IQEAAKEYTN ASAICAWDGE VTHDELNALT DRLAHHLRLE
LGVGPEKTVG VCMDKSKWAV VSMLAILKAG GAVLPLGVQL PVARIEFLLR DASAVAVLAN
QQHATRLRDV APKALVIDEQ LFSEIPELTG PACTDVKADS AAWVIYTSGS TGMPKGVVLQ
HSALSTSLLA QGPALGITKG TRTLQFAAYT FDVSIGETFA TLIRGGTVCI PSEDRRVNNL
AGTAADMRVN LAILTSTVAG LLEPAEVPLL STIVLAGEAA SPAVVDKWLG HAAVYNAYGP
AECSVLASSS KPMARKEDAP VIGYPLSGCF WVADPTDYNS LVPIGVIGEL LVEGPQLARE
YLGDEERTKT SFIQDPEFVT KLNLGHGHRM YRTGDLVQQN LDGSLIYIGR RDNQIKIRGQ
RVEVGEIEYL VTSHPAVKDA VVILADKGLL KNKLIGVIAT HDSIKDGGYG SSVEIADEHH
RQTASPYTAE IRRLLSQNIP AYMIPTLWVI LATIPINSSG KVDRAQIKQS LFTMDPKALG
LVLASNTQDK LRTVPATALE KQLLTAWSKT LNLVPEQIGY GQAFTAVGGD SVTAMQVVSE
LRKVGVTFSV RDVLQSQNIA ELALKAKSTT AHQAEETPYE PFALSPVQQM FFDDIAADGL
VSAGEHRYNQ GFWLSVERPT GVDELARAIE ILVGRHAMLR ARFFHDGEHG WKQRIQEELQ
GSYRFRAMQV ESDDDLAAIS NASQKSLDLE HGPVFSVDVV NRESQGQMMY VVAHHLVVDL
VSWRIILREL EELLRNRTMS EQVPLSFRSW NHLQSQYSQG LSDVSATLPY SVPSADWSYW
GLEQGYKAGD QIQKSVVLEE AITNKLFGDS NRALRTEPVE ILLAALFYSF QATFDNRPVP
AIFNEGHGRE TWDESVDLSE TVGWFTIMTP LACAEEHSDI VDLLAQTKDQ RRRIPSRGLP
YFTSRFLTEE GKRSFVDHRQ MEILFNYQGR YQQTESKDAL FRPIDLSNLT TKASAPAVGS
LVKQTAVFDI DVSRAVDSTH VAFRFSQHIS RQDDIARWML KFQMSVTELL HRLEQMEIRV
TSSDFPLTQL TRKDLMALQQ TSSSLPGLSS LDNIQDIYPC SPTQQGILIS QSKNPEGYQI
RQFIKISGMG GKPVDIAVIK CAWQRVINRH SILRTIFIDW LPSQLSYHQL VLKGWTADVP
IIACQDESAI KTHIKGLAEL KYGDNKLPHE FTLYQTETGE VYGFFQMSHT IVDAWSIDLI
VRDLVAACDR EAKFMPAPRY GDYISYLKED TSDKDIKYWT KLLGNVEPCH LQIEGQDSKS
ENESAFEIKS SIEDLTAFRG LQEKQGITSA SLLRFAWAVV LSAYTNSSQV DFGFLTHGRD
VPVSGIENLA GPTINMSVCH LRIDSGSASL DGIKKSQDLF LEGLEHQRSS LADIQHHLKL
SNQALFNTTM SYRQATSADA LKSSSIVIES VYAENPTEFD INVNIVAAQD RIDVELHYKL
SAVSHTAAQR LLETLVHVAD QLARQTVAKL DDLIMMSPED LNKIRTRNAL VPSRLHSFVH
ELVAEKTFTQ PHAPAVAAWD GDMTYQALDA VSQTLAGYLA SLGVGPETMV GVCMGKSKWA
VVSMLAILKA GGTVVPLGVN APLSRIEHIV RDTAATIVLV DVAQADRLAT IASNIIDVND
DLIDNLPACS TPPCAAISPD NAAYVIFTSG STGTPKGVIL EHGALCTSLR AHGKAFSLDA
HSRVLQFAAH TFDAAIQDIF TTLAFGGCVC IVSEDERMNN LAAGMRRTGV NFAALTSSVA
ALIHPDDTPD LKTIILVGEA VSEVVVKRWI QSSRLINAYG PAEGSICTTC TAPMRSDFEA
SNIGYPVAGC VWVTDPADYN RLCPPGVPGE LLIEGPLLAR GYLNDAEKTA AAFVREPKFL
KQIGISNRTG RLYRTGDLVR QNPDGSLTFM GRIDSQIKIA GQRVETGEIE NQIARLLPTV
RQVSVDLIQD PSRSGARTLV AAIEIHTNDT KPSQQSLEPV KYSRGLHKQI EALQDSLAEV
LPSYMVPKIF VPLVTLPVGA TGKLDRRALK QYLESLDNSE LRAFVANEAV KEPPSNDAER
MVQSLWAKIF KRPTSAIGIN DHFFHLGGDS VLAMQMIAAA HEEAMDLTVA DIFRMPRLHQ
LAAIVTQRGF KAESSESMNP APFNLAQHLL SSVSEERDRQ FAELAEQCSI GVEDIEDVYP
CTPLQENLIA STLHNAEAYI ARRVFRLRPE VATDRFMSTW TQLSEMQPIL RTRILFTTLL
QPVQVVVRKS VSWNTAESLQ QYLDTDRKQP IGEGEALCRL ALIDEGDRYF VWTMHHSIYD
GWSTSKMLEV LSNLLEEKPV SPAVPFSRFV KYVAVQDAET TQNFWRQQLD GVVSATRFPA
LPSASYKPRP TKKASLTLTA TRQPGQVTTS IALRAAWAKL VATYTNTDDL VIIEALSGRN
APVSGILDIL APTVTTVPVR VRLQPQQTIR KVLADLQQQS ADMIPFEQTG LQNIKRIAPG
AGSDLGSEHL FVVQTALEQA SKDNTGPFDR VLDADVPLDY ALLMECTMDL TRDTVDVQAS
FDEAVMSADQ IEMMLFHFQQ IFEQILAHGT GLEEETEKGE TMGGIDLLSK QDMDLIGSWN
AKPYQALDAC LPAQVTEAAS TRPDAQAVCA WDGAMTYAEL EQQAGRLAHY LSGRNVGPEI
KVGVCMAKSK WAVVSMLAVL KAGGVVVPLG ADHPLLRIQH MIRDTGMDLI LVDSAQAERL
ASTGPDLVIV SEVFVDSSLG QETFSRESIN PESAAWIVYT SGSTGTPKGV VLTHKSLCTS
IKAHGTAYGT SSGTRMLQFA AHTFDAAIQE VFTTLIFGGC VCIPSGDDRV NDLIRVICDM
DVSLAALTPS VAGMILPSSV PSLKTLILIG EAVTSAVLSK WIGAITVFNG YGPTECSIYT
TCKRMESVKD LGNIGSPLGG RVWVTNVTNY HQLCPVGAPG ELLVEGPILA REYLNDTPRS
SASFVENPGF VKRFGLEGQR MYRTGDLVRQ NLDGSITILG RLDTQAKLRG QRLEATEIEN
HIIQSQSGIQ SSVVSIVQLE GATTEPVLVA AIEFSSGSEF TKQEKQNDGL IESSDVLRAW
FQKTQESLYQ TLPAYMVPKI YIAMERLPLN TSGKLDRPKV RQLIESLHSD TLASYSSAGS
NTVEPATIME RQLQKLWASV LNKPQASVGA DDHFFQIGGD SVVAMRLVAS ARQEQIHLSV
AQIFKHPRLC DLASHIDHHT LLEETGDLAP FALWLGEDQA ESRSSAMQKL ASQCDVAVEQ
IEDIYPCTPL QEGMMALTMQ NPRAYVFQSV FRLDDTLQSE RLVAAWDKLV DIVPILRTRI
VALADSRSLQ CVIREPVQWK KSNSLKDYLR QDSQDIIKSG SRMSRCALIE GEKSERYFVW
TAHHGLYDGW SRMRMMELLS KIYNSETLPT LPPMSRFLSY LGGSSQADMK TFWQNQLANL
AVAKFPALPH ATYQPNVDCI AKRQLIGQPA NSSVTTSVAL RAAWAITVAT YTSSEEALLA
VALSGRTAPV EGILDLLAPT ITTVPVRIRI PHSRTVRELL EEVQKQATDM IPYEHAGLQN
MPQLVDDSSV LASLGHLFIV QSTLDGVSVR GHVAPEKTLG LHAEEANFTG LDSYALNVEC
TMLNEDKIHV DARFDKNVVS EKQVERVLDS FATVFAQLCD SSAAETLVQD VVVIGEKDAQ
AIRAENAVVT PTHERCIHDL VMDSTLKYPN EPAVHAWDGG FTYQQLDAAA TRLALYLSQQ
GVGPEVKVGF CMDKSKWAVV SILAILKAGG AVTPLGVQHP LPHIEKILSS TKATIILADA
QQASRLSGLA AKSVVVDGKL LESLPGSVSG QTVCKVVTPD NTAWVIHTSG STGTPKGVLL
HHSQLSTSFK HQTVAFGIGQ DTRTFQFSAF TFDVSISDVC LTLYVGGCVC LPSESDRMND
LEKTARDMEV NLLMITSTVA GLIQPTNVPS AKTLVLTGEA IAPNVVTQWL GHATILNAYG
PAECSVDSCS VAFTSPAMAS NIGYTTAACF WVVDQLNPHR LVPVGTIGEL LIEGPLVSHG
YLNDPEKTSQ SQMVGPAFFK QLGLEQSRGR IYRTGDLVRQ NADGSYEYLG RRDSQMKVHG
QRVEAAMIEE LIVRLLPDAH VSLVDLVLFG DGKADSTLVA SIEFKTDSIY QQHVTSSGLL
AATDELREAL YHVRTSLADS IPIYMVPSVF VPFARLPTNM SGKLDRKALQ QIYKTLGQEE
LDLYAPQAGE AAGAQPSTTA EIKLQALWAT VLRKPSAQYS TRDHFFQSGG DSVSAMRLVA
AARQEGLQLA VTDIFNNPRL EDMAKIVEEH VEEEELVDVA PFSLWEADIP TPEQRKSELA
DLAAQCKVAT DNIEDVYPAT PLQEGMMAIT MQSPRAYVSQ VVYRLDKEMD LDRLIRTWQR
AEQIAPILRT RIVARPEAAS VQVVIREQSE WSFGNDLEAY LAQDKKSPVT FGGPLSRFAL
ITSKQKSERY FVWTCHHSLY DGWSRNRIMD AVARAYTGEE VGPSTPVTRF LQHLGNAGEA
ETSKFWNTQL DGLTATKFPA LPHSGYQPYV KSVVSQRVRD TSINGVVTTS VLLRAAWAIV
VAAQTGNKDV LLTVSLSGRT VPVPGILDML APTLTTVPVR LRVEREQTIA AFLREAQKQA
TDMMPFEHTG LQGIRRLLPK NAAPLDPGHL FVVQTSLDKD DGSGSDTFGL TPMDPEIDGF
DSYALNISCT VLEDEQQVEI EARFDEQVLS QGRTTALLER FAKVYQQLSH LATANAGAGA
CVGDISTLCQ SDIAQLKDWS ARASYDKAEH CLHTLVHEAT IKYATSTAIE AWDGSMTYAE
LESAADRLAQ HLASLDVGPE TMVGMCMDKS KFAAVAFFAI LKAGGVCVPL GVQHPVSRVE
HIVQDAGATV LLVDKQQAER LNDMESDAKV ITVEEDFLSR LPQSNGFVCH NVTPDNAAWI
IYTSGSTGTP KGVVLQHSAI VSAMLGHNAA FGLNSKSRVL QFAAHTFDLL ISEIFSTLLC
GGTICIPSEE TRVSNLAQTA KAMGVNFTWL TSTVASMLTP QELPDLKTLI LIGEAASAAV
VETWLGHATV LNAYGPSECS IHSSCSKSMV KKEDTPVIGF PVCGNFWVVD AEDYHRLAPV
GGVGELLIQG PHLAREYLKD EAKTAAAFVN NARWASELGI THSTQKMYRT GDLVQQNPDG
SLTYLGRRDT QIKIRGQRVE VGEIEHHITQ HPAVWHAAIV RPSTGPLAGR LAAVVVLHHS
AAGNGYSSDV LPLEAELQMA NAVTQEVQSF LTERVMQYMV PSTWIPVAAL PMNLNRKTDL
GRLTRWVAEL DEKALTAYQT EAEDDELVSA RGTAMEEQLR TVFSRILNVS ESRTRLDRSF
LSLGGDSVTA MQVVAQCRRL GIQLSVRDVI QSKSISQLAL LASTDESEVA HDAVSYEPFA
LAPIQQMFFD QVASDGMNVM GENRYNQSVC VRLNQAIELS SLQAALDAVV DKHAMLRARF
QVDKQSWTQR ILETVQGSYR FQTVTAGSED EIFDILETAE SALDIENGPV FSVTVINAPG
RQLVFLVAHH LVIDLMSWRI ILTDLAELLQ NGGQDGKYTL DRSLSFPQWS RLQAEYSHTI
KSLDSVLPFD VPAADWAYWG LSAGDFVTRD KIHEHVEISK QITELLLGEG ANSALKTEPV
ELLLAALFQS FHKTFPNRLV PAIVNEGHGR EPWDSSVDLS ETVGWFTTMT PLHVPVDSQS
YDVVETLKQT KERRRQTPGR GLPYFTARYL TKEGRTKFAD HQMMEILFNY QGQYQQLERD
DTLFSLETLG GRGQPSRVGQ NVRELAVFDV AVTVSQGPLH VSIGFSKNIR RPKAVQDWLT
AYSKTLEELT TQLVSLAPTR TSSDFPLASL SQQDIDAIAT ENLSSTGLGF NDVEDVFPAS
PMQQGILLSM SKNPGTYYVQ QTCEFIPKAD VKYDTARLAS AWQLVVDRHA ILRTFFTDAL
PDQHAYHQIV LSAWTADVQI VKCAHQTEVQ SQIGARAQQA FAADQPPHRF TVYEVGDESL
YGHFEISHAL VDASSVQLLV HDLLRAYDGS LPAAQGPRYS SYISYLQERS PEEDLKYWTS
VLGDVEPCQV KTVTFGPAQP IDERPQNIAA EIENLEILQR FGEAHGVTLA TLFQLAWAMV
LGRHTGLQQV CFGYLLNGRD VPVAGIEEMV GPMINMMVCA VSLDNKELAV PEAAQLVQKQ
FLEGFEHQRT SLGDIQHAFK LSGQALFNSV LNYKAAQSTD GAQTTSLSIA GKGSEDPTEY
DISVNVTKTT DRISLSLQYA QAEVSPALAQ RLLDGLLQAV HTLAGSDASQ RMRNISLASV
KDVAKFREWN THTPPRVEST VHALVQKSVH ARPDATAICA WDGEMSYGEL DAAASRLASR
LVDDHGIGPE AKVGLCMDKS KWVVVAMLAI LKAGGAVLPL GVQHPLERIA HIVRETEAKV
VLVDEGQEKR LAEMDVSTLV VDEALVAGVS DALDSKTQTS SPDNTAWIIY TSGSTGTPKG
VVLQHGALAT SLLAHSKAFG MGVHTRSLQF AAHTFDASIQ DTMTTLTIGG CICIPSETER
MNSLSAAVAR MGANCANLTT TVVGLLHPSE VPSLKTIIFG GEAVLPSLVD LWAPHATLIN
SLGHTECSIN SSFSQPMTHG WQAPGIGKAI CGSFWVADQV DFNQLVSIGS VGELLIESPQ
LAKEYLRDSA KTAAAFVTDP DFVHQLGFTK GRRMYRTGDL VRQLEDGTLT YVGRRDTQVK
IRGQRVEIGE IESTVLAVLP EVRSVVVNLI KRGDSQQTLS VAVEFVAENT FLEGEVNTDT
GLIAPSKELL EAFGLLRDRL TEVLPLYMVP SIFVPLVKLP LNASGKLDRR ATQQLVESLD
DATIAAYSSS AAKVQPATDA ERQLQTLWAG VLDKDVNAIG ATDHFFQLGG DSVVAMRLVA
AARQENVQIS VADIFAHPRL RDLAKTIQDS ETADEEGDAA PFALWEESLD MANSQQRQQE
LIKLANECAV EVDQIEDVYP CTPLQEGFMA LTMQNPRAYV FQSCFELDSK IGTDTLISAW
EQLMDVVAIL RTRIVALPDS QSLQCVVREK LPWTFSNKSL DDFLASDNQT PMTSGSRLCR
CAIVEEPQDN KRYFVWTVHH GVYDGYSRSR MLELLTKILT GHSLPPLTPI PRFLQYLARV
DDDEAAAGRF WKAQLANVAA PKFPALPHAA YQPRVDSTAR MQIAGPRLAA SSGVTTAVAI
RTAWAIAVGA HTNSDEALLV VALSGRAAPV DGILDLLGPT LTTVPFRVRI DREKTLSELL
TQVQSQASDM IPFEHTGLQK VQVLAGSGPL ELGHLLTVQS TLSDERDDPV EALGMHAREV
SNLGSDSYAL NVECSIWNVE NKINVEARFD GNVISQDQVE AILDGFAAIF RQLCDENIAA
RTKVSEVSVI GEKGLELLRA RTDKMPAPYE VLVQNMVTNS LIKNPHAIAV NAWDGDLTYQ
QLDDAASCLA HHLVRSFGIK PEDKVAFCMD KSKRAVISML AILKAGGAVT PLGVTHPLQH
VQRVINNASS PLVLVDKKQA ERFAELSVPT ITIDDELLDN LPAYSGPACS SLTVNNTAWV
IHTSGSTGIP KGVLLHHSLI ATSAKYQAIL YGCVGPHTRT LQFAAHTFDM NIFEVFLTLY
GGGTICILSE EDRMNDLERQ ANAMKVTLAF LTSTVAGLLD PTKLPSLHTI VLTGEACTPS
VVQQWLDHAV VLNAYGPAEG SVASITKAYT HAEEYSNIGF ETAGCFWVVD QLNSDRLVPL
GTIGELIIEG PLVSPGYLND AEKTAQMFIV DPAWVTDLGP TRGRRMYKTG DLVRQNQDGS
FEYLGRRDNQ MKIRGQRVEA AEVESAIVRL LSGVRTAAVD LVKVGNDADK QVTLVGAFEF
VPGTEFTTQG EAEGGLLAPS QPLREALQTL RKDLLQGLPP YMVPSIFVPL VRLPQNLSGK
LDRRALRQML EGLDGTQLTS YASEDSERIE PATPMEMQLA KLWATVLRKP VESVSASDDF
FQSGGDSVAA MRLVAAGRQE DVDFTVADIF REPRLSGLAA LIQKQIDEEE EYDDSEEEEE
DDEEEVREVK GDVAPFALWK EEDGAIADLA AQCGVAISEV EDVYPCTPLQ EGLMAITMQS
PHAYVSQAVF KLGQDLDIAR FKAAWQKTTE KVSILRTRIL ACRDSASLQV VLRQPIEWKS
SGKTLHAYLA DDKDTPMTLG APLCRLAIVE NNNERHFVWT CHHSLYDGWS RHRTMDLVSR
IYAGSEVGSI TPMARFVNHL VKVREVDDTR QYWNAQLRGV TATKFPALPN ATYQPLVSTV
LRQKMSFTPL PGTITTAVML RVAWAMVCAA QTSNSDVLLA VSMSGRTIPV PGILDMLGPT
LTTVPVRISI DRDEGLHTFL KAAQRQATEM MPYEHTGLQA IRRLLPDGGA KVDLDAGHVF
IVQTSLDKTA DSVTRPFGSA LEPIDINQHG FDSYALNVSC TANDDEQEVE VEVRFDNKVI
SEYQMQSVLD RLATVLQQIG HLGQAAKVAD LQVLSETDKT KIKAWNGICP PRIESCVHML
THKQAIERPN APAICAWDGD MTQRELDAAA DRLAGHLASL GVGPEVKVGM CINKSKWAVV
CMLAILKAGG AVLPLGVQHP IPRIQHILRD TAADVILVDE EQVERLGSLG SETRLVTVDE
RLVSSLPQPA APVCSTVGPE NAAWVIYTSG STGVPKGVVL QHFALCTSLV AHGTAFGMGS
DTRSLQFAAY TFDASIQDTM TTLVNGGGCI CIPSEDERMN SLAAAIRRMK VNCATLTSTV
AGLLDPTEIP LLKTIAFGGE AVGPAVVERW GKYANLLNSY GATECSINSS CSKPMTEAHH
AANIGWAIPN SGVFWVVDSV DFNRLAPIGA VGELLIEGPQ LAREYLNDPV KTASSFVVDP
SFIAQLNLGS GRRMYRTGDL VQQQEDGSLI YLGRRDTQIK IRGQRVETGE IESAVRRFLP
DVRAAVVNLV QRGGDNALRV LTLAVEFIAE SSFQTGETSS TDLLAPSQAL REAFADLRDK
LLEILPPYMV PSIFVPFVKL PVNTSGKTDR RAVKELIEAL TEDALAAYTT TSLTKTEPAT
GMERHLQALW ASVLNKPIES VGANDHFFQS GGDSVVAMRL VAAARQKDIH LTVKDIFSFP
RLSDLARETE SQGAAEEEDV APFALWEQSG SNAIDEIARL CAVSSDGIED VYPCTPLQEG
LMAITLQHTN AYVSQRVFKL DASIDVAQFK NRWDSLVELL PILRTRIVPA SLSSSLQVVV
REAVQWQTAS SVEEYLRRDQ NTPMTHGGAL CRLALITEQD GTNTFVWTIH HSIYDGWSVI
KMMGMLDGLS REQTLPEVVP VSRFVKYLTQ QDPAASESFW KQQLEGANLT PFPALADTTY
KPRPTNRVRF QFSKLKRHGS VVAPAILRAA WAITVATYSG TDDVTLTVAL SGRNAPVPGI
TDIVAPTVTS VPVRIAIQQD QPVAAYLSAI QQQAVDMIPF EHTGLQNIKR IALPAGASFG
SGHLFIVQAS VDNDRAAATQ FSGMTEQFSD QDINMDYPLI VECTTDPEQA MVEVSVSFDN
AVLSPDMVDG MMHGFETIFQ QLSSVNEQDG TDNSVKISDV QLLGRKDSEM IQSWNKTLVP
RATDCLHHTF KRTADKQPER PAICAWDGNF TFHELNQTAD RLAAHLIARG VGAEVMVGVC
MNKSKWAVVG MLAILKAGGV VVPLGVQHPL ARIEHIVKDA DIRVVLVDSQ QGQRLGDNLA
EKIVVDDALL TSLPNPASVK DVRVTADSAA WVIYTSGSTG TPKGVVLEHG SLATSIQAQA
AAFGITPETR ALQFSAYTFD ISIQDMFATL LHGGCVCIPS EEARVVGLAG AIPELKVNSA
ALTSTVTALL DPAEVPDLKT ICFVGEAVNQ SVMDKWVHHC SLINAYGPAE ASICTTFNQI
KKGDAASTIG TPLAGRVWVV DPTNFNRLVP VGAPGELLIE GPLLARHYLN DPIKTEKAFV
QAPSFTPHFG ISAGTRMYRT GDLVRQNAIG SLTYIGRRDT QIKVRGQRVE IGEIESLVKR
LLPSAHTAVV DLITRKEGSE ALTVAIEFAA GQPASVANPS GSPLSSPTTA LREELSNLRA
ALFEALPSYM VPSVFVPVVK LPVNASGKLD RGAVRRLLQD LDDEQLGAYV SAEAERKEPS
TEMERRIQQL WSAVLKKPAT AIGANDHFFQ SGGDSVSAIR MIASARGMDV HLTVADVFKH
PRLSDLAAAV QGRITDEDEE DPAPFTLWQE SSVDDIAEHK AKMHDLASQC DLTAEQIEDV
YPATPLQEGL MAITMHSPEA YVSQAVFRLE DNIQVDQLIA AWESLVQMAP ILRTRIVSQP
GQSSLQIVVK ERTSWIRQTS LNIYLAEDKK LPIVSGGELS RTAVVEDKSK RYFVWTCHHS
IYDGWSRRKM MDLLARIYND EVVEGLTPIP RFIRYLTQVS RQDTETFWRA QLEGVAVSKF
PTLPHPTYQP RTSSMVRKTF SNASSANVAT MSAVLRAAWT LVVNAHTGTD DVLLAVSLSG
RTLPVPGILD LIAPTLTTVP VRNKIDRNQS ITSFLEQVQS QATAMMPFEH SGLQQIRRML
PGSGTDLDPG HLFMVQTNLD QEDVGAVSDI GLRFEETGVE GFDSYALNIL CTTSDGAHGT
EVEARFDDKV ISHARVEALL NRFDHVFAQL VTETTASQKR IQDIEMVSEQ DVAQMRSWNT
AASLQPVGMC VHDLIRDSFS SRADEIAICA CDGDLTYGEL DDASTRLAQY LVSLGVKPEV
KVGMSMDKSK WGPIAMLAIL KAGGVVVPLN VAHPVMRIEG IVKDTEMTIA VLDAGQADRI
GHLVSNAVVL DAAFLDSLPQ VNSRFSTTVT PENAAWIIYT SGSTGTPKGV VLQHSALSTS
LKAHGAAFGM NSSTRTLQFA ANSFDATISE FFATLLYGGT VCIPSEDDRM SDLTNICNSM
KVTLAMLTST VAALLGDIPT LKTLILVGEA ASPAVVEQWL SRATILNAYG PSECSIHASC
SKPMAAKEDT PIIGYALSGC FWVVDPTDHN RLAPLGGTGE LLIEGPQLAR EYLNDSAKTS
SAFVVDPAFI TKLGLGTGRR MYRTGDLVQQ REDGSLVYLG RRDTQIKIRG QRVETGEIEH
HIAQHSAVLR GAIVRPKTGP LAERLVAFVV LNELAVGSGY SSEVLEISAE DRTHANEVAT
GVKKYLSDRV MQYMVPGVWI TLAALPMNIN SKTDLLTLTR WAAEVDDETV ATYTNEDTQT
ASMPGTVQEE QLRSIFSLVL NIPEVRIPLD RSFLSLGGDS VTAMQVISQC RKQGITLTVR
DVIQSQSIQQ LGQKVKEAVD DNEELNKVSY KPFGLAPIQQ MFFEQIVPKQ GSGDGENRYN
QSVFLKLQQR YALEVIRRAV DAIVDKHAML RSRFERTADG LWTQRVAQKL DASYSFHNQS
VESEDEIYAI LDTAEKSLNI ENGPVFATRI IDTSDKQLLF LVAHHLVIDL MSWRIILNDF
AEALQGRSLA ASRSVSFEAW AKAQNEYSKT LQIEKVLPYT VPMADWNYWG VPIGSYLPAD
KVYQTIDVDE KTAALILGDS NTALQTEPVE ILLAALFHSF RRTFLDREVP AIVNEGHGRE
PWDDSIDLSE TVGWFTTMTP LHVAVEKDDL IKTLRGTKEH RRQTPGRGLP YFTSRYMTEQ
GREAFAHHRA IEVLFNYQGR YQQLERQDAV FSLESLARGV PSPVGANVPE LALFDVSVTA
LASTMQISIG YSRNIRDSAL VHEWATNYGN TLKDMTSTLL QMAPTRTPSD FPLATLTDAD
LSTIEKKNLV PASLVYANVE DILPCSPIQQ GILLGQVKAP STYHIQQTCR FRPKSKHTLE
TDVKRLSRAW QRVVQRHSIL RTFFVDSLAS HDSFHQVVLS SWSADVTVVN CTTADEAKAY
FATHNPFAAN QPPHRFTLVC VGGSDLYGHF EISHALVDAS SIELIVNDLL QAYDDKLTVA
PGPRYSSYVA HLQKSSAEAD LGYWTALLQD AQPCHVRDAP KDLQNVDNTL NKLTSQMTDV
ATLQRFSEIN GVTLATVFQL GWAMVLSSYT NLPQVCFGYL TNGRDVPLAQ VDEMVGPMIN
MMVCTIKLDG ETAVSEAAKH AQQSFLEGFD HQRTSLAAIH HALHLSGQPL FNSALSYKRE
QTVSGQQKPA SLALESVASE DPTEYDVSLD VNWSEHSIGL SLVHTRQLSS GLAKSLLDSL
VHVVTQLVRG DRTSKLRDIS IVGEHDLQQI KAWNTIVPSR MDATLHTLVR DAAHRTPDAL
AVHAWDGDYT HVELDSTVQR LATRLRALGV RPETRVAFCM DKSRFAPVAV LAILNAGGAV
VPLGVQHPVD RVNKIVLDAE AQVMLVDATQ AARLVGVVPN MIVVDDKFLH NLPNVDSEQS
QPTITPDNAA WVMYTSGSTG VPKGVVLPHG ALATSLMVNG KSFGMGPHTR TLQFASYTFD
DSIHDIIATL SFGGCICVPS ETQRMNSLAE AITSMRANTA AITPTVASLL DPKAVPTLKT
VLVGGEAATP QVIELWGPHA TLLNLYGPTE CSINACVSGP MTIAAHAASI GRPISGSGLV
WVVDPANPNA LVPLGAPGEL LLEGPQLARE YLNDPAKTSA AFILDPAFLK LLGIEDTGRR
MYRTGDLVIQ RADGSLDYLG RGDGQIKIRG QRVETGDIEA AVRRLMPAAR GAVVDLLARG
EQRMLIAAVE LVDGERADDG VLLAPSSEIR EAFSSLKTAL RNVLPPYMVP QSFVPLARLP
VNASGKLDRR AVTTILSGLT SDVLASYTSD QGDSQLPASA DEGALAGAWA RVLGVEQSSI
TRNDDLFHLG GDSISAMKLV QAARELDLHL SVADIFRNPR LADMASVASA ARTTQGEEQQ
YERFSLVETD KTALLAELPA LLKVEESTIH DALPVTDFQA LCVAGNTIGS GLEMNYFALD
GQHAVDLAAL KQGCKDLIQQ TEMLRTVFVF HQEQMLQVVL AMSNPPVTLH ETDEPLDTFT
QQLIERQTSQ PIRLGQPMAS IDIVASPSSA THRIIFRLSH ALYEGVALPM IFQRLSTLLA
GQALTQGPSF GAFVADLQSR ATQEAYSHWR SLLQGAQMPR LSSPPQEQRL FRMAPLPARS
VPLPASVQKG ITPAMLVKAS WAAVLARHTR TPDVVFAETV SGRASASPDV ADVLGCCAAI
LPVRATIRPD TTTAELLASV REQQILSAQN DALGARSIIR NCTEWEKGTR FTSRINHTLA
EDGAVALGEE EYKLSPLPPR EWMDVAEVSI ASFQFGDRVE VGMSFADDEL ERGVVEGLLR
ELCDIMVRLA SQQEGTVWDS EERSDSLLPS ASAVNGTNGS NGDGTDAANG IGQKTGGTGG
HAVEKSSGDA EVEKVSTNGH ADNNTSAENR QSELSAAIKH ATGTVLKNKL KTERSTEALW
SGHADVVDYA HVAFLLQRQG WSVLTEDLVR CRSETELIDV VVKREAERVK GNGSAFNGAN
GHYSNEESVN GNGLHGVQTN GHAGKGVTNG VNGGSKGHI
