ID   FRCA_RHIML              Reviewed;         260 AA.
AC   Q9F9B0;
DT   15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Fructose import ATP-binding protein FrcA {ECO:0000305};
DE            EC=7.5.2.- {ECO:0000269|PubMed:11466273};
GN   Name=frcA {ECO:0000303|PubMed:11466273};
OS   Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=382;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, AND
RP   SUBUNIT.
RC   STRAIN=SU47 / Rm5000;
RX   PubMed=11466273; DOI=10.1128/jb.183.16.4709-4717.2001;
RA   Lambert A., Osteras M., Mandon K., Poggi M.C., Le Rudulier D.;
RT   "Fructose uptake in Sinorhizobium meliloti is mediated by a high-affinity
RT   ATP-binding cassette transport system.";
RL   J. Bacteriol. 183:4709-4717(2001).
CC   -!- FUNCTION: Part of the high-affinity ABC transporter complex FrcBCA
CC       involved in fructose uptake. Is also a high-affinity transporter for
CC       ribose and mannose (PubMed:11466273). Responsible for energy coupling
CC       to the transport system (Probable). {ECO:0000269|PubMed:11466273,
CC       ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-fructose(out) + H2O = ADP + D-fructose(in) + H(+) +
CC         phosphate; Xref=Rhea:RHEA:60180, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:37721,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000269|PubMed:11466273};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60181;
CC         Evidence={ECO:0000269|PubMed:11466273};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (FrcA),
CC       two transmembrane proteins (FrcC) and a solute-binding protein (FrcB).
CC       {ECO:0000305|PubMed:11466273}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; AF196574; AAG28500.1; -; Genomic_DNA.
DR   RefSeq; WP_003531508.1; NZ_WISY01000026.1.
DR   AlphaFoldDB; Q9F9B0; -.
DR   SMR; Q9F9B0; -.
DR   STRING; 382.DU99_02555; -.
DR   TCDB; 3.A.1.2.7; the atp-binding cassette (abc) superfamily.
DR   GeneID; 61601954; -.
DR   PATRIC; fig|382.52.peg.516; -.
DR   OMA; DNMFMGR; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Sugar transport; Translocase; Transport.
FT   CHAIN           1..260
FT                   /note="Fructose import ATP-binding protein FrcA"
FT                   /id="PRO_0000439250"
FT   DOMAIN          7..251
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   260 AA;  28394 MW;  FAEBE977A68A1056 CRC64;
     MAQEPILTAR GLVKRYGRVT ALDRADFDLY PGEILAVIGD NGAGKSSMIK AISGAVTPDE
     GEIRLEGKPI QFRSPMEARQ AGIETVYQNL ALSPALSIAD NMFLGREIRK PGIMGKWFRS
     LDRAAMEKQA RAKLSELGLM TIQNINQAVE TLSGGQRQGV AVARAAAFGS KVVIMDEPTA
     ALGVKESRRV LELILDVRRR GLPIVLISHN MPHVFEVADR IHIHRLGRRL CVINPKDYTM
     SDAVAFMTGA KEPPREAIAA