ALDC_LACLA
ID ALDC_LACLA Reviewed; 236 AA.
AC P95676;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Alpha-acetolactate decarboxylase;
DE EC=4.1.1.5;
GN Name=aldB; OrderedLocusNames=LL1228; ORFNames=L0321;
OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272623;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NCDO 2118;
RX PubMed=8779600; DOI=10.1128/aem.62.7.2636-2640.1996;
RA Goupil N., Corthier G., Ehrlich S.D., Renault P.;
RT "Imbalance of leucine flux in Lactococcus lactis and its use for the
RT isolation of diacetyl-overproducing strains.";
RL Appl. Environ. Microbiol. 62:2636-2640(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NCDO 2118;
RX PubMed=9335274; DOI=10.1128/jb.179.20.6285-6293.1997;
RA Goupil-Feuillerat N., Cocaign-Bousquet M., Godon J.-J., Ehrlich S.D.,
RA Renault P.;
RT "Dual role of alpha-acetolactate decarboxylase in Lactococcus lactis subsp.
RT lactis.";
RL J. Bacteriol. 179:6285-6293(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
CC -!- FUNCTION: Converts acetolactate into acetoin.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2;
CC Xref=Rhea:RHEA:21580, ChEBI:CHEBI:15378, ChEBI:CHEBI:15686,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58476; EC=4.1.1.5;
CC -!- PATHWAY: Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-
CC butane-2,3-diol from pyruvate: step 2/3.
CC -!- SIMILARITY: Belongs to the alpha-acetolactate decarboxylase family.
CC {ECO:0000305}.
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DR EMBL; S82499; AAB37482.1; -; Genomic_DNA.
DR EMBL; U92974; AAB81923.1; -; Genomic_DNA.
DR EMBL; AE005176; AAK05326.1; -; Genomic_DNA.
DR PIR; D86778; D86778.
DR RefSeq; NP_267384.1; NC_002662.1.
DR RefSeq; WP_003131140.1; NC_002662.1.
DR AlphaFoldDB; P95676; -.
DR SMR; P95676; -.
DR STRING; 272623.L0321; -.
DR PaxDb; P95676; -.
DR EnsemblBacteria; AAK05326; AAK05326; L0321.
DR GeneID; 60357048; -.
DR KEGG; lla:L0321; -.
DR PATRIC; fig|272623.7.peg.1328; -.
DR eggNOG; COG3527; Bacteria.
DR HOGENOM; CLU_072561_0_0_9; -.
DR OMA; YKPMLEA; -.
DR BioCyc; MetaCyc:MON-8702; -.
DR UniPathway; UPA00626; UER00678.
DR Proteomes; UP000002196; Chromosome.
DR GO; GO:0047605; F:acetolactate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0045151; P:acetoin biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd17299; acetolactate_decarboxylase; 1.
DR InterPro; IPR005128; Acetolactate_a_deCO2ase.
DR PANTHER; PTHR35524; PTHR35524; 1.
DR Pfam; PF03306; AAL_decarboxy; 1.
DR PIRSF; PIRSF001332; Acetolac_decarb; 1.
DR TIGRFAMs; TIGR01252; acetolac_decarb; 1.
PE 3: Inferred from homology;
KW Acetoin biosynthesis; Decarboxylase; Lyase; Reference proteome.
FT CHAIN 1..236
FT /note="Alpha-acetolactate decarboxylase"
FT /id="PRO_0000218441"
SQ SEQUENCE 236 AA; 26353 MW; 3016555564C7C17D CRC64;
MTEITQLFQY NTLGALMAGL YEGTMTIGEL LKHGDLGIGT LDSVDGELIV LDGKAYQAKG
DKTIVELTDD IKVPYAAVVP HQAEVVFKQK FTASDKELED RIESYFDGQN LFRSIKITGE
FPKMHVRMIP RAKSGTRFVE VSQNQPEYTE ENVKGTIVGI WTPEMFHGVS VAGYHLHFIS
EDFTFGGHVL DFIIDNGTVE IGAIDQLNQS FPVQDRKFLF ADLDIEALKK DIDVAE
