ID   FRDA_ENCCU              Reviewed;         118 AA.
AC   Q8SWI3;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Frataxin, mitosomal;
DE            Short=Fxn;
GN   Name=YFH1; OrderedLocusNames=ECU01_1310;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11157783; DOI=10.1101/gr.164301;
RA   Peyret P., Katinka M.D., Duprat S., Duffieux F., Barbe V., Barbazanges M.,
RA   Weissenbach J., Saurin W., Vivares C.P.;
RT   "Sequence and analysis of chromosome I of the amitochondriate intracellular
RT   parasite Encephalitozoon cuniculi (Microspora).";
RL   Genome Res. 11:198-207(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [3]
RP   SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=18311129; DOI=10.1038/nature06606;
RA   Goldberg A.V., Molik S., Tsaousis A.D., Neumann K., Kuhnke G., Delbac F.,
RA   Vivares C.P., Hirt R.P., Lill R., Embley T.M.;
RT   "Localization and functionality of microsporidian iron-sulphur cluster
RT   assembly proteins.";
RL   Nature 452:624-628(2008).
CC   -!- FUNCTION: Promotes the assembly and repair of iron-sulfur clusters by
CC       delivering Fe(2+) to proteins involved in these pathways. {ECO:0000250,
CC       ECO:0000269|PubMed:18311129}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitosome {ECO:0000269|PubMed:18311129}.
CC   -!- SIMILARITY: Belongs to the frataxin family. {ECO:0000305}.
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DR   EMBL; AL391737; CAD25004.1; -; Genomic_DNA.
DR   RefSeq; XP_965969.1; XM_960876.1.
DR   AlphaFoldDB; Q8SWI3; -.
DR   SMR; Q8SWI3; -.
DR   STRING; 284813.Q8SWI3; -.
DR   PRIDE; Q8SWI3; -.
DR   GeneID; 860310; -.
DR   KEGG; ecu:ECU01_1310; -.
DR   VEuPathDB; MicrosporidiaDB:ECU01_1310; -.
DR   HOGENOM; CLU_080880_4_2_1; -.
DR   InParanoid; Q8SWI3; -.
DR   OMA; PSVMELW; -.
DR   OrthoDB; 1372185at2759; -.
DR   Proteomes; UP000000819; Chromosome I.
DR   GO; GO:0032047; C:mitosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0008199; F:ferric iron binding; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   Gene3D; 3.30.920.10; -; 1.
DR   InterPro; IPR002908; Frataxin/CyaY.
DR   InterPro; IPR036524; Frataxin/CyaY_sf.
DR   PANTHER; PTHR16821; PTHR16821; 1.
DR   Pfam; PF01491; Frataxin_Cyay; 1.
DR   SMART; SM01219; Frataxin_Cyay; 1.
DR   SUPFAM; SSF55387; SSF55387; 1.
DR   PROSITE; PS50810; FRATAXIN_2; 1.
PE   3: Inferred from homology;
KW   Ion transport; Iron; Iron transport; Mitosome; Reference proteome;
KW   Transport.
FT   CHAIN           1..118
FT                   /note="Frataxin, mitosomal"
FT                   /id="PRO_0000382930"
SQ   SEQUENCE   118 AA;  13906 MW;  4CDABCE55628FD4E CRC64;
     MLHKQTPEDV ITRQLYHKLA DETLTDLSEQ LDKELDGGYA DYKDGNLQIK IDNVGEYMFN
     KQPASMQIWA SSPITGPRKF DICRRHEWID LKSNTSFSRY IEEELRRMRS KMAGKHKK