ID   FRDA_TRAHO              Reviewed;         107 AA.
AC   B0YLW8; L7JX71;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Frataxin;
DE            Short=Fxn;
GN   Name=YFH1; ORFNames=THOM_1399;
OS   Trachipleistophora hominis (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Pleistophoridae;
OC   Trachipleistophora.
OX   NCBI_TaxID=72359;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBCELLULAR LOCATION.
RX   PubMed=18311129; DOI=10.1038/nature06606;
RA   Goldberg A.V., Molik S., Tsaousis A.D., Neumann K., Kuhnke G., Delbac F.,
RA   Vivares C.P., Hirt R.P., Lill R., Embley T.M.;
RT   "Localization and functionality of microsporidian iron-sulphur cluster
RT   assembly proteins.";
RL   Nature 452:624-628(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23133373; DOI=10.1371/journal.ppat.1002979;
RA   Heinz E., Williams T.A., Nakjang S., Noel C.J., Swan D.C., Goldberg A.V.,
RA   Harris S.R., Weinmaier T., Markert S., Becher D., Bernhardt J., Dagan T.,
RA   Hacker C., Lucocq J.M., Schweder T., Rattei T., Hall N., Hirt R.P.,
RA   Embley T.M.;
RT   "The genome of the obligate intracellular parasite Trachipleistophora
RT   hominis: new insights into microsporidian genome dynamics and reductive
RT   evolution.";
RL   PLoS Pathog. 8:E1002979-E1002979(2012).
CC   -!- FUNCTION: Promotes the assembly and repair of iron-sulfur clusters by
CC       delivering Fe(2+) to proteins involved in these pathways.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18311129}.
CC   -!- SIMILARITY: Belongs to the frataxin family. {ECO:0000305}.
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DR   EMBL; EF571315; ABS58599.1; -; Genomic_DNA.
DR   EMBL; JH993936; ELQ75646.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0YLW8; -.
DR   SMR; B0YLW8; -.
DR   STRING; 72359.B0YLW8; -.
DR   EnsemblFungi; ELQ75646; ELQ75646; THOM_1399.
DR   VEuPathDB; MicrosporidiaDB:THOM_1399; -.
DR   HOGENOM; CLU_080880_4_2_1; -.
DR   OMA; PSVMELW; -.
DR   Proteomes; UP000011185; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008199; F:ferric iron binding; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   Gene3D; 3.30.920.10; -; 1.
DR   InterPro; IPR002908; Frataxin/CyaY.
DR   InterPro; IPR036524; Frataxin/CyaY_sf.
DR   InterPro; IPR020895; Frataxin_CS.
DR   Pfam; PF01491; Frataxin_Cyay; 1.
DR   SMART; SM01219; Frataxin_Cyay; 1.
DR   SUPFAM; SSF55387; SSF55387; 1.
DR   PROSITE; PS01344; FRATAXIN_1; 1.
DR   PROSITE; PS50810; FRATAXIN_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Ion transport; Iron; Iron transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..107
FT                   /note="Frataxin"
FT                   /id="PRO_0000382931"
SQ   SEQUENCE   107 AA;  12434 MW;  873AA4F328D69A1D CRC64;
     MLQKIADQRS YLTAAHNTLT ALEKKLDNDY GEIEHNNNVI EYTVDGVGRY VVSRQPSVME
     LWVSSPITGP SKFGMVEKKF VEKKNGMEIM KYFEMEMERI KRMLGNR