FRDC_SERP5
ID FRDC_SERP5 Reviewed; 130 AA.
AC A8G8T5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Fumarate reductase subunit C {ECO:0000255|HAMAP-Rule:MF_00708};
DE AltName: Full=Fumarate reductase 15 kDa hydrophobic protein {ECO:0000255|HAMAP-Rule:MF_00708};
DE AltName: Full=Quinol-fumarate reductase subunit C {ECO:0000255|HAMAP-Rule:MF_00708};
DE Short=QFR subunit C {ECO:0000255|HAMAP-Rule:MF_00708};
GN Name=frdC {ECO:0000255|HAMAP-Rule:MF_00708}; OrderedLocusNames=Spro_0417;
OS Serratia proteamaculans (strain 568).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Serratia.
OX NCBI_TaxID=399741;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=568;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L.,
RA Vangronsveld J., van der Lelie D., Richardson P.;
RT "Complete sequence of chromosome of Serratia proteamaculans 568.";
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Two distinct, membrane-bound, FAD-containing enzymes are
CC responsible for the catalysis of fumarate and succinate
CC interconversion; fumarate reductase is used in anaerobic growth, and
CC succinate dehydrogenase is used in aerobic growth. Anchors the
CC catalytic components of the fumarate reductase complex to the cell
CC inner membrane, binds quinones. {ECO:0000255|HAMAP-Rule:MF_00708}.
CC -!- SUBUNIT: Part of an enzyme complex containing four subunits: a
CC flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic
CC anchor proteins (FrdC and FrdD). {ECO:0000255|HAMAP-Rule:MF_00708}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00708}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00708}.
CC -!- SIMILARITY: Belongs to the FrdC family. {ECO:0000255|HAMAP-
CC Rule:MF_00708}.
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DR EMBL; CP000826; ABV39525.1; -; Genomic_DNA.
DR RefSeq; WP_012004880.1; NC_009832.1.
DR AlphaFoldDB; A8G8T5; -.
DR SMR; A8G8T5; -.
DR STRING; 399741.Spro_0417; -.
DR EnsemblBacteria; ABV39525; ABV39525; Spro_0417.
DR KEGG; spe:Spro_0417; -.
DR eggNOG; COG3029; Bacteria.
DR HOGENOM; CLU_156492_0_0_6; -.
DR OMA; MTATWWQ; -.
DR OrthoDB; 2053102at2; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045284; C:plasma membrane fumarate reductase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0000104; F:succinate dehydrogenase activity; IEA:UniProtKB-UniRule.
DR CDD; cd00546; QFR_TypeD_subunitC; 1.
DR Gene3D; 1.20.1300.10; -; 1.
DR HAMAP; MF_00708; Fumarate_red_C; 1.
DR InterPro; IPR003510; Fumarate_red_C.
DR InterPro; IPR034804; SQR/QFR_C/D.
DR Pfam; PF02300; Fumarate_red_C; 1.
DR PIRSF; PIRSF000180; FrdC; 1.
DR SUPFAM; SSF81343; SSF81343; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..130
FT /note="Fumarate reductase subunit C"
FT /id="PRO_1000062066"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00708"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00708"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00708"
SQ SEQUENCE 130 AA; 14415 MW; B90FFF438AD0773A CRC64;
MTTQRKPYVR TMTPTWWQKL GFYRFYMLRE GTSVPAVWFS IVLIYGVFAL KGGVDSWAGF
VGFLQNPLVL LINFVALLAA LLHTKTWFDL APKAANIVVN SEKMGPGPIV KTLWAVTVVA
SVVILAVALV
