ID   ALDH2_GEOSE             Reviewed;          73 AA.
AC   P45959;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Aldehyde dehydrogenase;
DE            EC=1.2.1.3;
DE   Flags: Fragment;
OS   Geobacillus stearothermophilus (Bacillus stearothermophilus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=1422;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 2334 / Var. Non-diastaticus;
RX   PubMed=8049268; DOI=10.1016/0167-4781(94)90199-6;
RA   Robinson G.A., Bailey C.J., Dowds B.C.A.;
RT   "Gene structure and amino acid sequences of alcohol dehydrogenases of
RT   Bacillus stearothermophilus.";
RL   Biochim. Biophys. Acta 1218:432-434(1994).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.3;
CC   -!- PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol:
CC       step 2/2.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; Z25544; CAA80990.1; -; Genomic_DNA.
DR   PIR; S47644; S47644.
DR   AlphaFoldDB; P45959; -.
DR   SMR; P45959; -.
DR   UniPathway; UPA00780; UER00768.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006068; P:ethanol catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN           1..>73
FT                   /note="Aldehyde dehydrogenase"
FT                   /id="PRO_0000056443"
FT   NON_TER         73
SQ   SEQUENCE   73 AA;  7946 MW;  A023C282B453C9AD CRC64;
     MMSSIAAPKL KEKVEKFLSG KKKMYINGSF VESASGKTFD TPNPATGERL ATVYEGDAED
     IDRAVKAARE AFD