ID   FRE21_DISSA             Reviewed;          12 AA.
AC   P0DTV4;
DT   17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT   17-JUN-2020, sequence version 1.
DT   12-AUG-2020, entry version 2.
DE   RecName: Full=Frenatin-2.1D {ECO:0000303|PubMed:23262358};
OS   Discoglossus sardus (Tyrrhenian painted frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Alytidae; Discoglossinae; Discoglossus.
OX   NCBI_TaxID=191474;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RX   PubMed=23262358; DOI=10.1016/j.peptides.2012.12.012;
RA   Conlon J.M., Mechkarska M., Pantic J.M., Lukic M.L., Coquet L.,
RA   Leprince J., Nielsen P.F., Rinaldi A.C.;
RT   "An immunomodulatory peptide related to frenatin 2 from skin secretions of
RT   the Tyrrhenian painted frog Discoglossus sardus (Alytidae).";
RL   Peptides 40:65-71(2013).
CC   -!- FUNCTION: Probable defense peptide. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23262358}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:23262358}.
CC   -!- MASS SPECTROMETRY: Mass=1140.9; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:23262358};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Frenatin subfamily. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted.
FT   PEPTIDE         1..12
FT                   /note="Frenatin-2.1D"
FT                   /evidence="ECO:0000269|PubMed:23262358"
FT                   /id="PRO_0000450235"
SQ   SEQUENCE   12 AA;  1140 MW;  09A25584F6C76724 CRC64;
     GTLGNLPAPF PG