FRE31_NYCIN
ID FRE31_NYCIN Reviewed; 73 AA.
AC Q571V4;
DT 17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 55.
DE RecName: Full=Frenatin 3.1 {ECO:0000303|PubMed:15996792};
DE Flags: Precursor;
OS Nyctimystes infrafrenatus (White-lipped tree frog) (Litoria infrafrenata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae;
OC Nyctimystes.
OX NCBI_TaxID=61195;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 47-73, MASS SPECTROMETRY,
RP AND SUBCELLULAR LOCATION.
RC TISSUE=Skin;
RX PubMed=15996792; DOI=10.1016/j.peptides.2005.05.019;
RA Zhou M., Chen T., Walker B., Shaw C.;
RT "Novel frenatins from the skin of the Australasian giant white-lipped tree
RT frog, Litoria infrafrenata: cloning of precursor cDNAs and identification
RT in defensive skin secretion.";
RL Peptides 26:2445-2451(2005).
CC -!- FUNCTION: Antimicrobial peptide with activity against both Gram-
CC positive and Gram-negative bacteria. {ECO:0000250|UniProtKB:P56249}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15996792}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000305|PubMed:15996792}.
CC -!- MASS SPECTROMETRY: Mass=2829.95; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:15996792};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Frenatin subfamily. {ECO:0000305}.
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DR EMBL; AJ937525; CAI77674.1; -; mRNA.
DR AlphaFoldDB; Q571V4; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR InterPro; IPR016322; FSAP.
DR Pfam; PF03032; FSAP_sig_propep; 1.
DR PIRSF; PIRSF001822; Dermaseptin_precursor; 1.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Immunity; Innate immunity; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..46
FT /evidence="ECO:0000305|PubMed:15996792"
FT /id="PRO_0000450239"
FT PEPTIDE 47..73
FT /note="Frenatin 3.1"
FT /evidence="ECO:0000269|PubMed:15996792"
FT /id="PRO_5004250868"
FT REGION 25..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 73 AA; 8282 MW; CFAD4F5A9C35E3F4 CRC64;
MHFLKKSIFL VLFLGLVSLS ICEKEKREDQ NEEEVDENEE ASEEKRGLMS ILGKVAGNVL
GGLFKPKENV QKM