FRE_VIBOR
ID FRE_VIBOR Reviewed; 164 AA.
AC P43128;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=NAD(P)H-flavin reductase;
DE EC=1.5.1.-;
DE AltName: Full=NAD(P)H:flavin oxidoreductase;
DE Flags: Fragment;
GN Name=fre;
OS Vibrio orientalis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio; Vibrio oreintalis group.
OX NCBI_TaxID=28175;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 33934 / DSM 19136 / CCUG 16389 / LMG 7897 / NBRC 15638 / NCIMB
RC 2195 / CIP 102891 / 717;
RX PubMed=8206831; DOI=10.1128/jb.176.12.3544-3551.1994;
RA Zenno S., Saigo K.;
RT "Identification of the genes encoding NAD(P)H-flavin oxidoreductases that
RT are similar in sequence to Escherichia coli Fre in four species of luminous
RT bacteria: Photorhabdus luminescens, Vibrio fischeri, Vibrio harveyi, and
RT Vibrio orientalis.";
RL J. Bacteriol. 176:3544-3551(1994).
CC -!- FUNCTION: Involved in bioluminescence. It is a good supplier of reduced
CC flavin mononucleotide (FMNH2) to the bioluminescence reaction.
CC Preferably uses riboflavin as an electron acceptor when NADPH is used
CC as an electron donor.
CC -!- SIMILARITY: Belongs to the Fre/LuxG FAD/NAD(P) flavoprotein
CC oxidoreductase family. {ECO:0000305}.
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DR EMBL; D17747; BAA04599.1; -; Genomic_DNA.
DR AlphaFoldDB; P43128; -.
DR SMR; P43128; -.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008218; P:bioluminescence; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.80; -; 1.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR Pfam; PF00175; NAD_binding_1; 1.
DR SUPFAM; SSF52343; SSF52343; 1.
DR SUPFAM; SSF63380; SSF63380; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Luminescence; Oxidoreductase.
FT CHAIN <1..>164
FT /note="NAD(P)H-flavin reductase"
FT /id="PRO_0000068151"
FT BINDING 75..79
FT /ligand="pyridine"
FT /ligand_id="ChEBI:CHEBI:16227"
FT /evidence="ECO:0000250"
FT NON_TER 1
FT NON_TER 164
SQ SEQUENCE 164 AA; 18177 MW; 5A8F880FE777E41E CRC64;
GEKDKRPFSI ASSPCRHEGE LELHIGAAEQ NAYALEVVEA MKAALEQDGE ITIDAPHGDA
WVQEESERPL LLIAGGTGFS YVRSILDHCV AQELKNDIHL YWGGRDECQL YAKSELEEIA
AKHNNVHFVP VVEEAPSEWA GKTGNVLQAV EQDFDSLAEF DIYI