ID   FRG1_CAEEL              Reviewed;         274 AA.
AC   O18282;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 2.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Protein FRG1 homolog;
GN   Name=frg-1; ORFNames=ZK1010.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Binds to mRNA in a sequence-independent manner. May play a
CC       role in regulation of pre-mRNA splicing or in the assembly of rRNA into
CC       ribosomal subunits. May be involved in mRNA transport. May be involved
CC       in epigenetic regulation of muscle differentiation through regulation
CC       of activity of the histone-lysine N-methyltransferase KMT5B (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, Cajal body {ECO:0000250}. Nucleus,
CC       nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FRG1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z82083; CAB04969.2; -; Genomic_DNA.
DR   PIR; T27640; T27640.
DR   RefSeq; NP_499696.2; NM_067295.4.
DR   AlphaFoldDB; O18282; -.
DR   SMR; O18282; -.
DR   BioGRID; 41892; 2.
DR   DIP; DIP-26349N; -.
DR   STRING; 6239.ZK1010.3.2; -.
DR   EPD; O18282; -.
DR   PaxDb; O18282; -.
DR   PeptideAtlas; O18282; -.
DR   EnsemblMetazoa; ZK1010.3.1; ZK1010.3.1; WBGene00014177.
DR   GeneID; 176719; -.
DR   KEGG; cel:CELE_ZK1010.3; -.
DR   UCSC; ZK1010.3; c. elegans.
DR   CTD; 176719; -.
DR   WormBase; ZK1010.3; CE37862; WBGene00014177; frg-1.
DR   eggNOG; KOG3962; Eukaryota.
DR   GeneTree; ENSGT00390000004552; -.
DR   HOGENOM; CLU_094616_0_0_1; -.
DR   InParanoid; O18282; -.
DR   OMA; EQWEPIF; -.
DR   OrthoDB; 1400930at2759; -.
DR   PhylomeDB; O18282; -.
DR   PRO; PR:O18282; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00014177; Expressed in embryo and 4 other tissues.
DR   GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IDA:WormBase.
DR   GO; GO:0055120; C:striated muscle dense body; IDA:WormBase.
DR   GO; GO:0051015; F:actin filament binding; IDA:WormBase.
DR   GO; GO:0042803; F:protein homodimerization activity; IDA:WormBase.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051017; P:actin filament bundle assembly; IDA:WormBase.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR008999; Actin-crosslinking.
DR   InterPro; IPR010414; FRG1.
DR   PANTHER; PTHR12928; PTHR12928; 1.
DR   Pfam; PF06229; FRG1; 1.
DR   SUPFAM; SSF50405; SSF50405; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Cytoplasm; Myogenesis; Nucleus; Reference proteome;
KW   Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..274
FT                   /note="Protein FRG1 homolog"
FT                   /id="PRO_0000220770"
FT   REGION          27..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           20..36
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           252..268
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        29..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   274 AA;  30268 MW;  C9E57FFEFB4EBD16 CRC64;
     MPGADYSAVK GGGLKLKAGK KNLFKVGKEK KKKNKDDKEK IDPDTVENGG WRKIADEFDM
     KGGTNVAIEV ASGAGSTRTY VAAMDNGKFT IGFPHPEGEG PNPEEIFALV KTPDDSKISL
     KTGFGRYVGV DSEYQLVAMA EAIGSREQFV LVFQEGKTAF QAVSSPLFLS TVPNKEGHIY
     VASRTATENE MVNIRTDAIQ EGPVDWRSVE DRKNARECET AYVKMYQHSK VDLKNRHIAI
     DVKDKKGVKK AQADGSAHEL LLDRRMKMKS DRYC