FRG1_DROME
ID FRG1_DROME Reviewed; 262 AA.
AC Q9VWA8; Q4V3U4;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Protein FRG1 homolog;
GN Name=FRG1; ORFNames=CG6480;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23720823; DOI=10.1093/jmcb/mjt018;
RA Neguembor M.V., Xynos A., Onorati M.C., Caccia R., Bortolanza S., Godio C.,
RA Pistoni M., Corona D.F., Schotta G., Gabellini D.;
RT "FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone
RT methyltransferase and impairs myogenesis.";
RL J. Mol. Cell Biol. 5:294-307(2013).
CC -!- FUNCTION: May have a role in processing of pre-rRNA or in the assembly
CC of rRNA into ribosomal subunits (By similarity). May be involved in
CC epigenetic regulation of muscle differentiation through regulation of
CC the activity of the histone-lysine N-methyltransferase Suv4-20.
CC {ECO:0000250, ECO:0000269|PubMed:23720823}.
CC -!- SUBCELLULAR LOCATION: Nucleus, Cajal body {ECO:0000250}. Nucleus,
CC nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, myofibril,
CC sarcomere, Z line {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Increased trimethylation of 'Lys-20' of histone
CC H4. {ECO:0000269|PubMed:23720823}.
CC -!- SIMILARITY: Belongs to the FRG1 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF49040.1; -; Genomic_DNA.
DR EMBL; BT023262; AAY55678.1; -; mRNA.
DR RefSeq; NP_649202.1; NM_140945.3.
DR AlphaFoldDB; Q9VWA8; -.
DR SMR; Q9VWA8; -.
DR BioGRID; 65491; 2.
DR DIP; DIP-23801N; -.
DR IntAct; Q9VWA8; 1.
DR STRING; 7227.FBpp0074616; -.
DR PaxDb; Q9VWA8; -.
DR PRIDE; Q9VWA8; -.
DR DNASU; 40228; -.
DR EnsemblMetazoa; FBtr0074847; FBpp0074616; FBgn0036964.
DR GeneID; 40228; -.
DR KEGG; dme:Dmel_CG6480; -.
DR UCSC; CG6480-RA; d. melanogaster.
DR CTD; 2483; -.
DR FlyBase; FBgn0036964; FRG1.
DR VEuPathDB; VectorBase:FBgn0036964; -.
DR eggNOG; KOG3962; Eukaryota.
DR GeneTree; ENSGT00390000004552; -.
DR HOGENOM; CLU_094616_0_0_1; -.
DR InParanoid; Q9VWA8; -.
DR OMA; EQWEPIF; -.
DR OrthoDB; 1400930at2759; -.
DR PhylomeDB; Q9VWA8; -.
DR BioGRID-ORCS; 40228; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 40228; -.
DR PRO; PR:Q9VWA8; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036964; Expressed in eye disc (Drosophila) and 29 other tissues.
DR Genevisible; Q9VWA8; DM.
DR GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0055120; C:striated muscle dense body; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0070828; P:heterochromatin organization; IGI:FlyBase.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR GO; GO:0070511; P:negative regulation of histone H4-K20 methylation; IMP:FlyBase.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR008999; Actin-crosslinking.
DR InterPro; IPR010414; FRG1.
DR PANTHER; PTHR12928; PTHR12928; 1.
DR Pfam; PF06229; FRG1; 1.
DR SUPFAM; SSF50405; SSF50405; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Myogenesis; Nucleus; Reference proteome; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..262
FT /note="Protein FRG1 homolog"
FT /id="PRO_0000220771"
FT REGION 16..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 23..39
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 239..255
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 24..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 262 AA; 29530 MW; ACC90001A761CEC1 CRC64;
MSDYDHARIK KLVLKGEKLK KSKKRKKEKD EAGSSKKAKV VVDEDAVKHG GWWAAKTAAD
ITGTVSIEFG DRSYLKAMDN GLFTLGAPHN AGDGPDPEEI FTAFPINDRK VAFKSGYGKY
LKIEKDGMVT GRSEAVGGME QWEPVFEEQR MALLSETGHF MSIDPQDDAC VALRKKVGQH
EICKVRSNAS RDVVIDTEPK EEKGDLGEVE KNYVKKFQKF QDKKMRINQN DVKELEQAKA
QGSLHETLLD RRSKMKADRY CK
