ID   FRG1_SCHPO              Reviewed;         245 AA.
AC   Q9P7X3;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Protein frg1;
GN   Name=frg1; ORFNames=SPBP23A10.12;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [3]
RP   IDENTIFICATION IN THE SPLICEOSOME.
RX   PubMed=21386897; DOI=10.1371/journal.pone.0016719;
RA   Ren L., McLean J.R., Hazbun T.R., Fields S., Vander Kooi C., Ohi M.D.,
RA   Gould K.L.;
RT   "Systematic two-hybrid and comparative proteomic analyses reveal novel
RT   yeast pre-mRNA splicing factors connected to Prp19.";
RL   PLoS ONE 6:E16719-E16719(2011).
CC   -!- FUNCTION: May have a role in processing of pre-rRNA or in the assembly
CC       of rRNA into ribosomal subunits. May be involved in pre-mRNA splicing
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the spliceosome. {ECO:0000269|PubMed:21386897}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the FRG1 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAB66440.1; -; Genomic_DNA.
DR   PIR; T50399; T50399.
DR   RefSeq; NP_595824.1; NM_001021728.2.
DR   AlphaFoldDB; Q9P7X3; -.
DR   SMR; Q9P7X3; -.
DR   BioGRID; 277840; 2.
DR   STRING; 4896.SPBP23A10.12.1; -.
DR   iPTMnet; Q9P7X3; -.
DR   MaxQB; Q9P7X3; -.
DR   PaxDb; Q9P7X3; -.
DR   PRIDE; Q9P7X3; -.
DR   EnsemblFungi; SPBP23A10.12.1; SPBP23A10.12.1:pep; SPBP23A10.12.
DR   GeneID; 2541328; -.
DR   KEGG; spo:SPBP23A10.12; -.
DR   PomBase; SPBP23A10.12; frg1.
DR   VEuPathDB; FungiDB:SPBP23A10.12; -.
DR   eggNOG; KOG3962; Eukaryota.
DR   HOGENOM; CLU_1134130_0_0_1; -.
DR   InParanoid; Q9P7X3; -.
DR   OMA; TFQIQTL; -.
DR   PhylomeDB; Q9P7X3; -.
DR   PRO; PR:Q9P7X3; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; ISS:PomBase.
DR   GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0045292; P:mRNA cis splicing, via spliceosome; ISS:PomBase.
DR   InterPro; IPR008999; Actin-crosslinking.
DR   InterPro; IPR010414; FRG1.
DR   PANTHER; PTHR12928; PTHR12928; 1.
DR   Pfam; PF06229; FRG1; 1.
DR   SUPFAM; SSF50405; SSF50405; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..245
FT                   /note="Protein frg1"
FT                   /id="PRO_0000220773"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   245 AA;  27675 MW;  C322E1C0D0A1A798 CRC64;
     MSMRLTFKGD KKIQKKKKKN TKSLQSSLES AENDPFWTDA NELNELEGPA VIYKIDDDAG
     VSLGIEEVKE SCVLLPLDKV SLEPELTRQV FLLSILNNTI LLKSCLGKYM SCSKSGDLYC
     TQEAVGSQEQ WIAENLGSGF WAWKSVSTKK YLTLSREKQD QAIACVSDTV IPEAKWRIRV
     QTRFLKKNKS SLFDNPTIHS RQLESMAGRK LSTDEKKTLK KAFKEGVLHE ALLDLRVSSR
     SDKYG