ID   FRG1_TAKRU              Reviewed;         255 AA.
AC   O73747; Q548D5;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Protein FRG1;
GN   Name=frg1;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9714712; DOI=10.1016/s0378-1119(98)00334-5;
RA   Grewal P.K., Todd L.C., van der Maarel S., Frants R.R., Hewitt J.E.;
RT   "FRG1, a gene in the FSH muscular dystrophy region on human chromosome
RT   4q35, is highly conserved in vertebrates and invertebrates.";
RL   Gene 216:13-19(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Gonad;
RA   Bolland D.J., van Geel M., Carim-Todd L., Beck A.F., Grewal P.K.,
RA   van der Maarel S., Frants R.R., de Jong P.J., Hewitt J.E.;
RT   "Comparative sequence analysis of an evolutionary chromosomal breakpoint in
RT   human, mouse and Fugu rubripes.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to mRNA in a sequence-independent manner. May play a
CC       role in regulation of pre-mRNA splicing or in the assembly of rRNA into
CC       ribosomal subunits. May be involved in mRNA transport. May be involved
CC       in epigenetic regulation of muscle differentiation through regulation
CC       of activity of the histone-lysine N-methyltransferase KMT5B.
CC       {ECO:0000250|UniProtKB:Q14331}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, Cajal body
CC       {ECO:0000250|UniProtKB:Q14331}. Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q14331}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q14331}. Cytoplasm, myofibril, sarcomere, Z line
CC       {ECO:0000250|UniProtKB:Q14331}.
CC   -!- SIMILARITY: Belongs to the FRG1 family. {ECO:0000305}.
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DR   EMBL; AF042797; AAC18059.1; -; Genomic_DNA.
DR   EMBL; AF389402; AAK69356.1; -; mRNA.
DR   RefSeq; NP_001027774.1; NM_001032602.1.
DR   AlphaFoldDB; O73747; -.
DR   SMR; O73747; -.
DR   STRING; 31033.ENSTRUP00000041436; -.
DR   PRIDE; O73747; -.
DR   Ensembl; ENSTRUT00000041580; ENSTRUP00000041436; ENSTRUG00000016208.
DR   GeneID; 445937; -.
DR   KEGG; tru:445937; -.
DR   CTD; 2483; -.
DR   eggNOG; KOG3962; Eukaryota.
DR   GeneTree; ENSGT00390000004552; -.
DR   HOGENOM; CLU_094616_0_0_1; -.
DR   InParanoid; O73747; -.
DR   OrthoDB; 1400930at2759; -.
DR   Proteomes; UP000005226; Chromosome 17.
DR   GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR008999; Actin-crosslinking.
DR   InterPro; IPR010414; FRG1.
DR   PANTHER; PTHR12928; PTHR12928; 1.
DR   Pfam; PF06229; FRG1; 1.
DR   SUPFAM; SSF50405; SSF50405; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Myogenesis; Nucleus; Reference proteome;
KW   Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..255
FT                   /note="Protein FRG1"
FT                   /id="PRO_0000220769"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           21..31
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           232..248
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   255 AA;  28729 MW;  465D78C7A707D6D7 CRC64;
     MAEYTKVKST KLVLKGQKQG KKHKHKDRKR KATDEDEKPD IVGGWWVVKS FVEMNGTVAL
     EMQNNAYIHA LDSGLFTLGA PHKDDEGPDP PEQFTTIKLS DSRIALKSGY GRYLGINSEG
     LVVGRSDAIG PREQWEPVFQ DGKMALLAAN SCFISYSDSG DIVANSKTAG DEEMLKIRTS
     AERETRSKDD LAEEDRGNVK SCEVNYVKKF QSFQDRRLRV NEGDSMTLKK ARTDGKFHEA
     LLDRRSKMKA DRYCK