FRG2B_HUMAN
ID FRG2B_HUMAN Reviewed; 278 AA.
AC Q96QU4; Q5VSQ1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Protein FRG2-like-1;
DE AltName: Full=FSHD region gene 2 protein family member B;
DE AltName: Full=HSA10-FRG2;
GN Name=FRG2B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11829491; DOI=10.1006/geno.2002.6690;
RA van Geel M., Dickson M.C., Beck A.F., Bolland D.J., Frants R.R.,
RA van der Maarel S.M., de Jong P.J., Hewitt J.E.;
RT "Genomic analysis of human chromosome 10q and 4q telomeres suggests a
RT common origin.";
RL Genomics 79:210-217(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15520407; DOI=10.1136/jmg.2004.019364;
RA Rijkers T., Deidda G., van Koningsbruggen S., van Geel M.,
RA Lemmers R.J.L.F., van Deutekom J.C.T., Figlewicz D., Hewitt J.E.,
RA Padberg G.W., Frants R.R., van der Maarel S.M.;
RT "FRG2, an FSHD candidate gene, is transcriptionally upregulated in
RT differentiating primary myoblast cultures of FSHD patients.";
RL J. Med. Genet. 41:826-836(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FRG2 family. {ECO:0000305}.
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DR EMBL; AY028079; AAK21977.1; -; Genomic_DNA.
DR EMBL; AY744466; AAV30885.1; -; mRNA.
DR EMBL; AL731696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS44502.1; -.
DR RefSeq; NP_001074467.1; NM_001080998.1.
DR AlphaFoldDB; Q96QU4; -.
DR STRING; 9606.ENSP00000401310; -.
DR CarbonylDB; Q96QU4; -.
DR iPTMnet; Q96QU4; -.
DR PhosphoSitePlus; Q96QU4; -.
DR BioMuta; FRG2B; -.
DR DMDM; 74717197; -.
DR PaxDb; Q96QU4; -.
DR PeptideAtlas; Q96QU4; -.
DR PRIDE; Q96QU4; -.
DR Antibodypedia; 55950; 106 antibodies from 16 providers.
DR DNASU; 441581; -.
DR Ensembl; ENST00000425520.2; ENSP00000401310.1; ENSG00000225899.8.
DR GeneID; 441581; -.
DR KEGG; hsa:441581; -.
DR MANE-Select; ENST00000425520.2; ENSP00000401310.1; NM_001080998.2; NP_001074467.1.
DR UCSC; uc010qvg.2; human.
DR CTD; 441581; -.
DR GeneCards; FRG2B; -.
DR HGNC; HGNC:33518; FRG2B.
DR HPA; ENSG00000225899; Not detected.
DR neXtProt; NX_Q96QU4; -.
DR PharmGKB; PA162388920; -.
DR VEuPathDB; HostDB:ENSG00000225899; -.
DR eggNOG; ENOG502SNAQ; Eukaryota.
DR GeneTree; ENSGT00530000064266; -.
DR HOGENOM; CLU_087494_0_0_1; -.
DR InParanoid; Q96QU4; -.
DR OrthoDB; 986863at2759; -.
DR PhylomeDB; Q96QU4; -.
DR TreeFam; TF342559; -.
DR PathwayCommons; Q96QU4; -.
DR BioGRID-ORCS; 441581; 30 hits in 965 CRISPR screens.
DR GenomeRNAi; 441581; -.
DR Pharos; Q96QU4; Tdark.
DR PRO; PR:Q96QU4; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q96QU4; protein.
DR Bgee; ENSG00000225899; Expressed in right hemisphere of cerebellum and 10 other tissues.
DR ExpressionAtlas; Q96QU4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR026245; FRG2.
DR PANTHER; PTHR31883; PTHR31883; 1.
DR Pfam; PF15315; FRG2; 1.
DR PRINTS; PR02074; PROTEINFRG2.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome.
FT CHAIN 1..278
FT /note="Protein FRG2-like-1"
FT /id="PRO_0000300691"
FT REGION 1..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 278 AA; 30564 MW; 38E4BDA1AEBED435 CRC64;
MGKGNEDPDL HCSSIQCSTD QPPFQQISFT EKGSDEKKPF KEKGKTAFSH SSEKHIQRQG
SEPNPNKENS EETKLKAGNS TAGSEPESSS YRENCRKRKM SSKDSCQDTA GNCPEKECSL
SLNKKSRSST PVHNSEIQET CDAHHRGRSR ACTGRSKRHR SRALGVQTPS IRKSLVTSVR
AMSEAVYQDL AQVWAQQIHS PLTCEQLTLL TRLRGPLCAQ VQTLYSMATQ AAYVFPAESW
LVPATLPGPG ESALDREAHP FPGQEITETV SGSDEAKL
