ID   FRHD_METTH              Reviewed;         158 AA.
AC   P19497;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Coenzyme F420 hydrogenase subunit delta;
DE   AltName: Full=Putative coenzyme F420 hydrogenase-processing subunit;
GN   Name=frhD; OrderedLocusNames=MTH_1299;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=2207102; DOI=10.1021/bi00483a011;
RA   Alex L.A., Reeve J.N., Orme-Johnson W.H., Walsh C.T.;
RT   "Cloning, sequence determination, and expression of the genes encoding the
RT   subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing
RT   hydrogenase from Methanobacterium thermoautotrophicum delta H.";
RL   Biochemistry 29:7237-7244(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- MISCELLANEOUS: Does not copurify with the active FRH.
CC   -!- SIMILARITY: Belongs to the peptidase A31 family. {ECO:0000305}.
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DR   EMBL; J02914; AAA72188.1; -; Genomic_DNA.
DR   EMBL; AE000666; AAB85779.1; -; Genomic_DNA.
DR   PIR; F69039; F69039.
DR   RefSeq; WP_010876914.1; NC_000916.1.
DR   AlphaFoldDB; P19497; -.
DR   SMR; P19497; -.
DR   STRING; 187420.MTH_1299; -.
DR   EnsemblBacteria; AAB85779; AAB85779; MTH_1299.
DR   GeneID; 24854416; -.
DR   KEGG; mth:MTH_1299; -.
DR   PATRIC; fig|187420.15.peg.1270; -.
DR   HOGENOM; CLU_099037_0_2_2; -.
DR   OMA; GCGNLIF; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd06064; H2MP_F420-Reduc; 1.
DR   Gene3D; 3.40.50.1450; -; 1.
DR   InterPro; IPR004411; Pept_A31_F420-red_hyd_d.
DR   InterPro; IPR023430; Pept_HybD-like_dom_sf.
DR   InterPro; IPR000671; Peptidase_A31.
DR   PANTHER; PTHR30302; PTHR30302; 1.
DR   Pfam; PF01750; HycI; 1.
DR   PRINTS; PR00446; HYDRGNUPTAKE.
DR   SUPFAM; SSF53163; SSF53163; 1.
DR   TIGRFAMs; TIGR00130; frhD; 1.
DR   TIGRFAMs; TIGR00072; hydrog_prot; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease; Hydrolase; Protease; Reference proteome.
FT   CHAIN           1..158
FT                   /note="Coenzyme F420 hydrogenase subunit delta"
FT                   /id="PRO_0000201947"
SQ   SEQUENCE   158 AA;  17650 MW;  3041A39B5E7565BC CRC64;
     MPYDAEILVV GCGNILFKDD GFGPEVIKAL EEYFKDREKP DNVMFIDAGT GGPHFVFSLP
     HEEWKKMIVV DVVEFNAEPG TLRKFDVTEI PKGSYENMHT WPVSQPLHEL SEKIDVVVIG
     CKPKEISAPN VEMGLTPPVK KAIPRAIQMI LDEIGVSK