ALDH3_DICDI
ID ALDH3_DICDI Reviewed; 470 AA.
AC Q54DG1; Q86MX3;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Aldehyde dehydrogenase family 3 comG;
DE EC=1.2.1.5;
DE AltName: Full=Communication mutant protein G;
GN Name=comG; ORFNames=DDB_G0292270;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 269-347.
RX PubMed=12871696; DOI=10.1016/s0012-1606(03)00204-5;
RA Kibler K., Nguyen T.-L., Svetz J., Van Driessche N., Ibarra M.,
RA Thompson C., Shaw C., Shaulsky G.;
RT "A novel developmental mechanism in Dictyostelium revealed in a screen for
RT communication mutants.";
RL Dev. Biol. 259:193-208(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NADP(+) = a carboxylate + 2 H(+) + NADPH;
CC Xref=Rhea:RHEA:11888, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349; EC=1.2.1.5;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.5;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000189; EAL61259.1; -; Genomic_DNA.
DR EMBL; AY221644; AAO34400.1; -; Genomic_DNA.
DR RefSeq; XP_629680.1; XM_629678.1.
DR AlphaFoldDB; Q54DG1; -.
DR SMR; Q54DG1; -.
DR STRING; 44689.DDB0185188; -.
DR PaxDb; Q54DG1; -.
DR EnsemblProtists; EAL61259; EAL61259; DDB_G0292270.
DR GeneID; 8628596; -.
DR KEGG; ddi:DDB_G0292270; -.
DR dictyBase; DDB_G0292270; comG.
DR eggNOG; KOG2456; Eukaryota.
DR HOGENOM; CLU_005391_3_1_1; -.
DR InParanoid; Q54DG1; -.
DR OMA; NDCLWHL; -.
DR PhylomeDB; Q54DG1; -.
DR Reactome; R-DDI-1660661; Sphingolipid de novo biosynthesis.
DR Reactome; R-DDI-211945; Phase I - Functionalization of compounds.
DR Reactome; R-DDI-389599; Alpha-oxidation of phytanate.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-9603798; Class I peroxisomal membrane protein import.
DR Reactome; R-DDI-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR PRO; PR:Q54DG1; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005811; C:lipid droplet; HDA:dictyBase.
DR GO; GO:0004028; F:3-chloroallyl aldehyde dehydrogenase activity; ISS:dictyBase.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0033721; F:aldehyde dehydrogenase (NADP+) activity; IEA:RHEA.
DR GO; GO:0006081; P:cellular aldehyde metabolic process; ISS:dictyBase.
DR GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR Gene3D; 3.40.309.10; -; 1.
DR Gene3D; 3.40.605.10; -; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR PANTHER; PTHR43570; PTHR43570; 1.
DR Pfam; PF00171; Aldedh; 1.
DR PIRSF; PIRSF036492; ALDH; 1.
DR SUPFAM; SSF53720; SSF53720; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; NAD; Oxidoreductase; Reference proteome.
FT CHAIN 1..470
FT /note="Aldehyde dehydrogenase family 3 comG"
FT /id="PRO_0000342179"
FT ACT_SITE 218
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT ACT_SITE 252
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT BINDING 196..201
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
SQ SEQUENCE 470 AA; 52563 MW; 26F49BE34D31A205 CRC64;
MSTSAAATLP LSVISKNLRK VFLSQKTRKI DWRYSQLKAI KKMMSENKDN ITAAVKKDLG
KHEFEIHQTE IVMIQTELDE TISHLESWNK TEKVYSPLHF KPASSYILKE PLGVVLIMSP
WNYPVNLALI PLIGAIAGGN CALLKLSRHS YNISKLLHGL LTKYLDPECF EFDCEGGAPY
ITELLEYKWD HIFFTGSVKV GKIVYQAAAK FLTPVTLELG GKNPCIVDKD TDIKLTARRL
IWGKCWNAGQ TCIGLDYLIV HKSILEPLIE EFKVVLKEFF GEDIKKSTSF ARIISSAAAE
RLQQLFSMGK VVIGGEADIA ERYIAPTVIV DPDLDSPLMQ DEIFGPVLPI VTYENIDECL
EFIQNRPHAL TLYLFSRDQA IQDKVLDGTQ SGSLMINDTL LHFTNPNLPF GGIGDSGIGS
YHGKGTFDIF VHKRGLVQST TKKFLDLPLR YPPYTPFSDN VAGKILGSGW
