ID   FRIL_RABIT              Reviewed;         175 AA.
AC   P09451;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Ferritin light chain;
DE            Short=Ferritin L subunit;
GN   Name=FTL;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Liver;
RX   PubMed=3412911; DOI=10.1093/nar/16.15.7741;
RA   Daniels-Mcqueen S., Ray A., Walden W.E., Ray B.K., Brown P.H., Thach R.E.;
RT   "Nucleotide sequence of cDNA encoding rabbit ferritin L chain.";
RL   Nucleic Acids Res. 16:7741-7741(1988).
CC   -!- FUNCTION: Stores iron in a soluble, non-toxic, readily available form.
CC       Important for iron homeostasis. Iron is taken up in the ferrous form
CC       and deposited as ferric hydroxides after oxidation. Also plays a role
CC       in delivery of iron to cells. Mediates iron uptake in capsule cells of
CC       the developing kidney (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Oligomer of 24 subunits. There are two types of subunits: L
CC       (light) chain and H (heavy) chain. The major chain can be light or
CC       heavy, depending on the species and tissue type. The functional
CC       molecule forms a roughly spherical shell with a diameter of 12 nm and
CC       contains a central cavity into which the insoluble mineral iron core is
CC       deposited.
CC   -!- SIMILARITY: Belongs to the ferritin family. {ECO:0000305}.
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DR   EMBL; X07830; CAA30682.1; -; mRNA.
DR   PIR; S01239; S01239.
DR   RefSeq; NP_001095158.1; NM_001101688.1.
DR   AlphaFoldDB; P09451; -.
DR   SMR; P09451; -.
DR   STRING; 9986.ENSOCUP00000016423; -.
DR   GeneID; 100009254; -.
DR   KEGG; ocu:100009254; -.
DR   CTD; 2512; -.
DR   eggNOG; KOG2332; Eukaryota.
DR   InParanoid; P09451; -.
DR   OrthoDB; 1249457at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0008043; C:intracellular ferritin complex; ISS:UniProtKB.
DR   GO; GO:0008199; F:ferric iron binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; ISS:UniProtKB.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0006826; P:iron ion transport; IEA:InterPro.
DR   Gene3D; 1.20.1260.10; -; 1.
DR   InterPro; IPR001519; Ferritin.
DR   InterPro; IPR012347; Ferritin-like.
DR   InterPro; IPR009040; Ferritin-like_diiron.
DR   InterPro; IPR009078; Ferritin-like_SF.
DR   InterPro; IPR014034; Ferritin_CS.
DR   InterPro; IPR008331; Ferritin_DPS_dom.
DR   PANTHER; PTHR11431; PTHR11431; 1.
DR   Pfam; PF00210; Ferritin; 1.
DR   SUPFAM; SSF47240; SSF47240; 1.
DR   PROSITE; PS00540; FERRITIN_1; 1.
DR   PROSITE; PS00204; FERRITIN_2; 1.
DR   PROSITE; PS50905; FERRITIN_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Iron; Iron storage; Metal-binding; Reference proteome.
FT   CHAIN           1..175
FT                   /note="Ferritin light chain"
FT                   /id="PRO_0000201065"
FT   DOMAIN          7..156
FT                   /note="Ferritin-like diiron"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
FT   BINDING         54
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
FT   BINDING         57
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
FT   BINDING         58
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
FT   BINDING         61
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
FT   BINDING         64
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
SQ   SEQUENCE   175 AA;  20075 MW;  3B02FBF2FB6E2EB6 CRC64;
     MTSQIRQNYS PEVEAAVNHL VNLHLRASYT YLSLGFYFDR DDVALEGVSH FFRELAEEKR
     EAAERLLKMQ NQRGGRALFQ DVQKPSQDEW GKTLNAMEAA LALEKNLNQA LLDLHALGSA
     HTDPHLCDFL ENHFLDEEVK LLKKMGDHLT NIRRLSGPQA SLGEYLFERL TLKHD