ID   FRIP1_ARATH             Reviewed;         355 AA.
AC   Q8S8K9;
DT   28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Protein FIP1 {ECO:0000305};
DE   AltName: Full=FRIGIDA-interacting protein 1 {ECO:0000303|PubMed:19429606};
GN   Name=FIP1 {ECO:0000303|PubMed:19429606};
GN   OrderedLocusNames=At2g06005 {ECO:0000312|Araport:AT2G06005};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   INTERACTION WITH FRI, AND DISRUPTION PHENOTYPE.
RX   PubMed=19429606; DOI=10.1104/pp.109.137448;
RA   Geraldo N., Baeurle I., Kidou S., Hu X., Dean C.;
RT   "FRIGIDA delays flowering in Arabidopsis via a cotranscriptional mechanism
RT   involving direct interaction with the nuclear cap-binding complex.";
RL   Plant Physiol. 150:1611-1618(2009).
CC   -!- SUBUNIT: Interacts with FRI. {ECO:0000269|PubMed:19429606}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC       conditions. {ECO:0000269|PubMed:19429606}.
CC   -!- SIMILARITY: Belongs to the TMEM192 family. {ECO:0000305}.
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DR   EMBL; AC005970; AAM15099.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC05993.1; -; Genomic_DNA.
DR   EMBL; AY086482; AAM63484.1; -; mRNA.
DR   RefSeq; NP_565332.1; NM_126614.3.
DR   AlphaFoldDB; Q8S8K9; -.
DR   SMR; Q8S8K9; -.
DR   IntAct; Q8S8K9; 1.
DR   STRING; 3702.AT2G06005.1; -.
DR   PaxDb; Q8S8K9; -.
DR   ProteomicsDB; 228946; -.
DR   EnsemblPlants; AT2G06005.1; AT2G06005.1; AT2G06005.
DR   GeneID; 815154; -.
DR   Gramene; AT2G06005.1; AT2G06005.1; AT2G06005.
DR   KEGG; ath:AT2G06005; -.
DR   Araport; AT2G06005; -.
DR   TAIR; locus:505006239; AT2G06005.
DR   eggNOG; ENOG502QT7U; Eukaryota.
DR   OMA; PWIFESE; -.
DR   OrthoDB; 932704at2759; -.
DR   PhylomeDB; Q8S8K9; -.
DR   PRO; PR:Q8S8K9; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q8S8K9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   InterPro; IPR029399; TMEM192.
DR   PANTHER; PTHR31592; PTHR31592; 1.
DR   Pfam; PF14802; TMEM192; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..355
FT                   /note="Protein FIP1"
FT                   /id="PRO_0000443508"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          331..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          220..337
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   355 AA;  40586 MW;  92EE836EE3F67AA2 CRC64;
     MSTERRASSN PMTNEENAMF LDILHEAPLF GHRKSRSLVG SYLYMLLLAG YAILAAGAPW
     MFHRVQQLTP SLLCCCDVAL LVVTGVFQQY FVYQVQKIRL QGYYSFSQKL KHVVRLPFAI
     AAYGTAAMLL VIVWRPQIHI LSISSLQRII MLVEAVGAGF FMGLYIGYVH QYNSVNSRPD
     VLKSLYSPLQ PSSSMEGLRY YEGRLSDQQT ALLQYQRENL HFLSEEILCL QEKLSKYEQS
     DDGSTPQVDL AHLLAARDQE LRTLSAEMNQ LQSELRLARS LIAERDAEVQ RVNSTNNQYI
     EENERLRAIL SEWSMRAANL ERALEVERMS NSELQKEVAS TRRKQMLETT TSEQP