FRITZ_DROME
ID FRITZ_DROME Reviewed; 951 AA.
AC Q9VQ36;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=WD repeat-containing and planar cell polarity effector protein fritz;
GN Name=frtz; ORFNames=CG17657;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=15654087; DOI=10.1534/genetics.104.033381;
RA Collier S., Lee H., Burgess R., Adler P.;
RT "The WD40 repeat protein fritz links cytoskeletal planar polarity to
RT frizzled subcellular localization in the Drosophila epidermis.";
RL Genetics 169:2035-2045(2005).
CC -!- FUNCTION: Probable effector of the planar cell polarity signaling
CC pathway which regulates the septin cytoskeleton in both ciliogenesis
CC and collective cell movements. Functions cell autonomously to regulate
CC wing cell hair polarity and number. {ECO:0000269|PubMed:15654087}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm,
CC cytoskeleton, cilium axoneme {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis mainly in embryonic
CC epidermis. {ECO:0000269|PubMed:15654087}.
CC -!- SIMILARITY: Belongs to the WD repeat fritz family. {ECO:0000305}.
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DR EMBL; AE014134; AAF51346.1; -; Genomic_DNA.
DR EMBL; BT004832; AAO45188.1; -; mRNA.
DR RefSeq; NP_001259879.1; NM_001272950.1.
DR RefSeq; NP_608614.1; NM_134770.2.
DR AlphaFoldDB; Q9VQ36; -.
DR BioGRID; 59589; 8.
DR IntAct; Q9VQ36; 3.
DR STRING; 7227.FBpp0077577; -.
DR PaxDb; Q9VQ36; -.
DR EnsemblMetazoa; FBtr0077911; FBpp0077577; FBgn0086698.
DR EnsemblMetazoa; FBtr0333544; FBpp0305724; FBgn0086698.
DR GeneID; 33349; -.
DR KEGG; dme:Dmel_CG17657; -.
DR UCSC; CG17657-RA; d. melanogaster.
DR CTD; 33349; -.
DR FlyBase; FBgn0086698; frtz.
DR VEuPathDB; VectorBase:FBgn0086698; -.
DR eggNOG; ENOG502QR8Y; Eukaryota.
DR GeneTree; ENSGT00390000016551; -.
DR InParanoid; Q9VQ36; -.
DR OrthoDB; 692945at2759; -.
DR PhylomeDB; Q9VQ36; -.
DR Reactome; R-DME-450728; Inhibition of actin polymerisation.
DR SignaLink; Q9VQ36; -.
DR BioGRID-ORCS; 33349; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33349; -.
DR PRO; PR:Q9VQ36; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0086698; Expressed in capitellum (Drosophila) and 21 other tissues.
DR ExpressionAtlas; Q9VQ36; baseline and differential.
DR Genevisible; Q9VQ36; DM.
DR GO; GO:0097541; C:axonemal basal plate; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044782; P:cilium organization; IBA:GO_Central.
DR GO; GO:0045184; P:establishment of protein localization; IBA:GO_Central.
DR GO; GO:0035320; P:imaginal disc-derived wing hair site selection; IMP:FlyBase.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR024511; Frtz.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13667; PTHR13667; 1.
DR Pfam; PF11768; Frtz; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation;
KW Cytoplasm; Cytoskeleton; Membrane; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..951
FT /note="WD repeat-containing and planar cell polarity
FT effector protein fritz"
FT /id="PRO_0000406198"
FT REPEAT 304..343
FT /note="WD 1"
FT REPEAT 345..384
FT /note="WD 2"
FT REGION 709..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 816..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 903..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 951 AA; 106066 MW; AC9992D0D0DB3CE5 CRC64;
MLLSETHFWT TLREDVVRIK SQDLGAFRYL RQRDKEQEQQ DLACLAKRDY TERRNGLAVL
KNSGRKSTGR LKDNLKKLED LLRQHRIIHS EWQDAAQVLL LFSHGLIAHI CVDIYTGDIL
RMVFEKYLVG KLASEVITDA FFTRSHIVLA YNTNQLTVVH LQRPNARSQG PEKIANMDPR
IFHVIIPGAT ERKLSRHLTV NASFDLFVVW TQSSQNEVYP WRPTIRDQDR ANIHVFKIKG
LQLESIAYCW SENDPLCVDF LRSSESQIIT LEQKVSRKGD ISAEICSYEL AAGKMQRTAI
TSIPMGAQIC SFAFSPDQEK LFLGSVDRNI CLHDLVQQST KYANQIEIVP NQCAWHCDSA
MLCVANERSV LQCFDLALAT IGHQLVSENV TPSSLLDLSH YFVAQPTLLS VAFSRKPDLS
TFKHTYAQTD CLLLLVYEQG PLACMRIFGG TGMRGDIHNS GLTADVIADK YLRLQQPDRA
VNVLAALNWE TYGAMCLITL HKIANYVFFG GDQRRPRIEL MARALKTFAH TLSEETKDEF
SDQVYDLKRR FCFYLLRKNL FAEAFEIAQD VADYDIFMDL YNLTKCISSL SEFAQVAFSQ
AAAIIHEEDR ANGNLSLTCD LRSESACSLS TCSDMLRGQG AGTAPETGLG ASQPQSQQVL
KNYVPPLPSF KSKVFNAEMI KINIPKPELR PPLPKVSIAP PTSSLASLTL KSNSSLQQAP
AKSLHPNGNL WSQDVPDQTV GLPMASSPLP RLPPSNIPDQ SAQLGQFSTM PASPPPTGSY
QPKFYQHPLV SGNIPAMLPS LTSEDYQKRL LQKKPTASIL SNPANPAPTN GEAPATPAKS
QTAEKNKVKF SDTIQVAVVP EIPRKEKPMP PKRNGYSRPA ARHLTNPKKE LADSLPLCHP
NDEYLKDFNP ITTNVTKPPI RRREEEPKSS SKGGNSSSSS SSIKVVHFGV V
