ID   FRL2A_ARATH             Reviewed;         473 AA.
AC   A0SWL0;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=FRIGIDA-like protein 2;
DE            Short=AtFRL2;
GN   Name=FRL2;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=17056759; DOI=10.1104/pp.106.085571;
RA   Schlappi M.R.;
RT   "FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates
RT   for a nonsense allele of FRIGIDA LIKE 1.";
RL   Plant Physiol. 142:1728-1738(2006).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=20405310; DOI=10.1007/s11103-010-9635-2;
RA   Risk J.M., Laurie R.E., Macknight R.C., Day C.L.;
RT   "FRIGIDA and related proteins have a conserved central domain and family
RT   specific N- and C- terminal regions that are functionally important.";
RL   Plant Mol. Biol. 73:493-505(2010).
CC   -!- FUNCTION: Involved in flowering time regulation. Required for FRI-
CC       mediated up-regulation of FLC transcripts. Partially redundant with
CC       FRL1. {ECO:0000269|PubMed:17056759}.
CC   -!- MISCELLANEOUS: In cv. Columbia and cv. Landsberg erecta, either FRL1 or
CC       FRL2, but not both, is functional and required for FRI-mediated up-
CC       regulation of FLC (PubMed:17056759). {ECO:0000305|PubMed:17056759}.
CC   -!- SIMILARITY: Belongs to the Frigida family. {ECO:0000305}.
CC   -!- CAUTION: The protein in cv. Landsberg erecta and cv. Columbia (AC
CC       Q9C6S2) only differ by two residues in positions 132 and 401 (Ala to
CC       Pro and Leu to Gln changes, respectively); these variations leading to
CC       inactivate the protein in cv. Columbia. {ECO:0000305}.
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DR   EMBL; EF052678; ABK79074.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0SWL0; -.
DR   SMR; A0SWL0; -.
DR   ExpressionAtlas; A0SWL0; baseline and differential.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR   InterPro; IPR012474; Frigida.
DR   Pfam; PF07899; Frigida; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Developmental protein; Differentiation; Flowering.
FT   CHAIN           1..473
FT                   /note="FRIGIDA-like protein 2"
FT                   /id="PRO_0000423741"
FT   REGION          356..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          3..35
FT                   /evidence="ECO:0000255"
FT   COILED          306..361
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        359..374
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   473 AA;  52823 MW;  4D75086FC433AB7B CRC64;
     MTAAESIAAS INQIDEKKQK LKKAFDDLQA HRSLLSPSFN LSWSEIDSHF SSLQSSLFNR
     LQSAVTSSNS GNIETPTAVT TETPVLWPEL RKFCEKNDGK GLGNYMIENS RKRLSINEEL
     PNAIRCSENP AALVLDAIEG SYHCSSPSSS SSARAIDVKR IFVLLLEALI EINANLTNDL
     RERARTIAYD WKPNIGNKPS EALGFLHLVA AFELGSLFST EEICDYIFLI SKYKQATTIC
     KKIGLDRNRI GVLVQKFLDT GRLLVAIRFI YENEMVGEFE PVSILKTSLK NSREAAKRVC
     AEGNYSLKVQ NEATDKELSA LRAVIKVVKE KNIESEFMEE KLEECVKELE DQKAQRKRAT
     KFNSPANPQQ PQEQKVDNKR PRVANGSSME YNLTIPPLRP LQQPPLLPTP SQILQVNPYG
     LLSSILPGVA VPYGNPRALF GSVPAPASRP VFYVQQTGYG MPPPQYRPPY YPQ