FRL2I_ARATH
ID FRL2I_ARATH Reviewed; 473 AA.
AC Q9C6S2;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Inactive FRIGIDA-like protein 2;
DE Short=AtFRL2;
GN Name=FRL2; OrderedLocusNames=At1g31814;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DISRUPTION PHENOTYPE, AND GENE
RP FAMILY.
RX PubMed=14973192; DOI=10.1073/pnas.0306778101;
RA Michaels S.D., Bezerra I.C., Amasino R.M.;
RT "FRIGIDA-related genes are required for the winter-annual habit in
RT Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:3281-3285(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Shinn P., Chen H., Cheuk R., Kim C.J., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=17056759; DOI=10.1104/pp.106.085571;
RA Schlappi M.R.;
RT "FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates
RT for a nonsense allele of FRIGIDA LIKE 1.";
RL Plant Physiol. 142:1728-1738(2006).
RN [7]
RP GENE FAMILY, NOMENCLATURE, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=20405310; DOI=10.1007/s11103-010-9635-2;
RA Risk J.M., Laurie R.E., Macknight R.C., Day C.L.;
RT "FRIGIDA and related proteins have a conserved central domain and family
RT specific N- and C- terminal regions that are functionally important.";
RL Plant Mol. Biol. 73:493-505(2010).
CC -!- FUNCTION: Inactive FRIGIDA-like 2 protein.
CC {ECO:0000269|PubMed:14973192, ECO:0000269|PubMed:17056759}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels throughout the plant, with
CC slightly higher expression in developing seeds and the highest
CC expression in pollen. {ECO:0000269|PubMed:20405310}.
CC -!- DISRUPTION PHENOTYPE: No effect on flowering time, due to a partial
CC redundancy with FRL1. Frl1 and frl2 double mutants flower earlier than
CC frl1 single mutant. {ECO:0000269|PubMed:14973192}.
CC -!- MISCELLANEOUS: In cv. Columbia and cv. Landsberg erecta, either FRL1 or
CC FRL2, but not both, is functional and required for FRI-mediated up-
CC regulation of FLC (PubMed:17056759). {ECO:0000305|PubMed:17056759}.
CC -!- SIMILARITY: Belongs to the Frigida family. {ECO:0000305}.
CC -!- CAUTION: The sequence displayed is a non-functional allele found in cv.
CC Columbia. The protein in cv. Landsberg erecta (AC A0SWL0) only differ
CC by two residues in positions 132 and 401 (Pro to Ala and Gln to Leu
CC changes, respectively); these variations leading to activate the
CC protein in cv. Landsberg erecta. {ECO:0000305}.
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DR EMBL; BK004885; DAA05286.1; -; Genomic_DNA.
DR EMBL; AC079041; AAG50711.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31397.1; -; Genomic_DNA.
DR EMBL; BT012571; AAS99715.1; -; mRNA.
DR EMBL; AK226705; BAE98812.1; -; mRNA.
DR PIR; A86442; A86442.
DR RefSeq; NP_174463.1; NM_102917.4.
DR AlphaFoldDB; Q9C6S2; -.
DR SMR; Q9C6S2; -.
DR STRING; 3702.AT1G31814.1; -.
DR PaxDb; Q9C6S2; -.
DR PRIDE; Q9C6S2; -.
DR EnsemblPlants; AT1G31814.1; AT1G31814.1; AT1G31814.
DR GeneID; 840070; -.
DR Gramene; AT1G31814.1; AT1G31814.1; AT1G31814.
DR KEGG; ath:AT1G31814; -.
DR Araport; AT1G31814; -.
DR TAIR; locus:2826175; AT1G31814.
DR eggNOG; ENOG502QUKS; Eukaryota.
DR HOGENOM; CLU_032433_0_0_1; -.
DR InParanoid; Q9C6S2; -.
DR OMA; CSAMDGP; -.
DR OrthoDB; 1089519at2759; -.
DR PhylomeDB; Q9C6S2; -.
DR PRO; PR:Q9C6S2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C6S2; baseline and differential.
DR Genevisible; Q9C6S2; AT.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
DR InterPro; IPR012474; Frigida.
DR Pfam; PF07899; Frigida; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Developmental protein; Differentiation; Flowering;
KW Reference proteome.
FT CHAIN 1..473
FT /note="Inactive FRIGIDA-like protein 2"
FT /id="PRO_0000423740"
FT REGION 356..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3..35
FT /evidence="ECO:0000255"
FT COILED 306..361
FT /evidence="ECO:0000255"
FT COMPBIAS 359..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 52864 MW; E658609EB9AD61CC CRC64;
MTAAESIAAS INQIDEKKQK LKKAFDDLQA HRSLLSPSFN LSWSEIDSHF SSLQSSLFNR
LQSAVTSSNS GNIETPTAVT TETPVLWPEL RKFCEKNDGK GLGNYMIENS RKRLSINEEL
PNAIRCSENP APLVLDAIEG SYHCSSPSSS SSARAIDVKR IFVLLLEALI EINANLTNDL
RERARTIAYD WKPNIGNKPS EALGFLHLVA AFELGSLFST EEICDYIFLI SKYKQATTIC
KKIGLDRNRI GVLVQKFLDT GRLLVAIRFI YENEMVGEFE PVSILKTSLK NSREAAKRVC
AEGNYSLKVQ NEATDKELSA LRAVIKVVKE KNIESEFMEE KLEECVKELE DQKAQRKRAT
KFNSPANPQQ PQEQKVDNKR PRVANGSSME YNLTIPPLRP QQQPPLLPTP SQILQVNPYG
LLSSILPGVA VPYGNPRALF GSVPAPASRP VFYVQQTGYG MPPPQYRPPY YPQ
