FRLA_ECO57
ID FRLA_ECO57 Reviewed; 445 AA.
AC Q8X845;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 24-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Probable fructoselysine/psicoselysine transporter FrlA {ECO:0000250|UniProtKB:P45539};
GN Name=frlA; OrderedLocusNames=Z4731, ECs4221;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Is likely involved in the transport of fructoselysine and
CC psicoselysine to the cytoplasm, where they are degraded.
CC {ECO:0000250|UniProtKB:P45539}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6)-(D-fructosyl)-L-lysine(in) = N(6)-(D-fructosyl)-L-
CC lysine(out); Xref=Rhea:RHEA:28454, ChEBI:CHEBI:61393;
CC Evidence={ECO:0000250|UniProtKB:P45539};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28456;
CC Evidence={ECO:0000250|UniProtKB:P45539};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6)-(D-psicosyl)-L-lysine(in) = N(6)-(D-psicosyl)-L-
CC lysine(out); Xref=Rhea:RHEA:28450, ChEBI:CHEBI:61403;
CC Evidence={ECO:0000250|UniProtKB:P45539};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28452;
CC Evidence={ECO:0000250|UniProtKB:P45539};
CC -!- PATHWAY: Carbohydrate metabolism; fructoselysine degradation.
CC {ECO:0000250|UniProtKB:P45539}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P45539}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG58478.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB37644.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE005174; AAG58478.1; ALT_INIT; Genomic_DNA.
DR EMBL; BA000007; BAB37644.1; ALT_INIT; Genomic_DNA.
DR PIR; B86002; B86002.
DR PIR; E91156; E91156.
DR RefSeq; NP_312248.2; NC_002695.1.
DR AlphaFoldDB; Q8X845; -.
DR SMR; Q8X845; -.
DR STRING; 155864.EDL933_4576; -.
DR EnsemblBacteria; AAG58478; AAG58478; Z4731.
DR EnsemblBacteria; BAB37644; BAB37644; ECs_4221.
DR GeneID; 915924; -.
DR KEGG; ece:Z4731; -.
DR KEGG; ecs:ECs_4221; -.
DR PATRIC; fig|386585.9.peg.4406; -.
DR eggNOG; COG0531; Bacteria.
DR HOGENOM; CLU_007946_3_4_6; -.
DR OMA; HKAFGIH; -.
DR UniPathway; UPA00784; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR InterPro; IPR002293; AA/rel_permease1.
DR Pfam; PF13520; AA_permease_2; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..445
FT /note="Probable fructoselysine/psicoselysine transporter
FT FrlA"
FT /id="PRO_0000054248"
FT TRANSMEM 10..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..433
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 445 AA; 47543 MW; B986F23F27E8AE5F CRC64;
MGSQELQRKL GFWAVLAIAV GTTVGSGIFV SVGEVAKAAG TPWLTVLAFV IGGLIVIPQM
CVYAELSTAY PENGADYVYL KNAGSRPLAF LSGWASFWAN DAPSLSIMAL AIVSNLGFLT
PIDPLLGKFI AAGLIIAFML LHLRSVEGGA AFQTLITIAK IIPFTIVIGL GIFWFKAENF
AAPATTAIGA TGSFMALLAG ISATSWSYTG MASICYMTGE IKNPGKTMPR ALIGSCLLVL
VLYTLLALVI SGLMPFDKLA NSETPISDAL TWIPALGSTA GIFVAITAMI VILGSLSSCV
MYQPRLEYAM AKDNLFFKCF GHVHPKYNTP DVSIILQGAL GIFFIFVSDL TSLLGYFTLV
MCFKNTLTFG SIIWCRKRDD YKPLWRTPAF GLMTPLAIAS SLILVASTFV WAPIPGLICA
VIVIATGLPA YAFWAKRSRQ LNALS
