ID   FRLB_SHIFL              Reviewed;         340 AA.
AC   P0AC01; P45540;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Fructoselysine 6-phosphate deglycase {ECO:0000250|UniProtKB:P0AC00};
DE            EC=3.5.-.- {ECO:0000250|UniProtKB:P0AC00};
GN   Name=frlB; OrderedLocusNames=SF3390, S4373;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Catalyzes the reversible conversion of fructoselysine 6-
CC       phosphate to glucose 6-phosphate and lysine. May function in a
CC       fructoselysine degradation pathway that allows S.flexneri to grow on
CC       fructoselysine or psicoselysine. {ECO:0000250|UniProtKB:P0AC00}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine = D-glucose 6-
CC         phosphate + L-lysine; Xref=Rhea:RHEA:28382, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32551, ChEBI:CHEBI:61392, ChEBI:CHEBI:61548;
CC         Evidence={ECO:0000250|UniProtKB:P0AC00};
CC   -!- PATHWAY: Carbohydrate metabolism; fructoselysine degradation; D-glucose
CC       6-phosphate and lysine from fructoselysine: step 2/2.
CC       {ECO:0000250|UniProtKB:P0AC00}.
CC   -!- SUBUNIT: Homododecamer. {ECO:0000250|UniProtKB:P0AC00}.
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DR   EMBL; AE005674; AAN44852.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP19326.1; -; Genomic_DNA.
DR   RefSeq; NP_709145.4; NC_004337.2.
DR   RefSeq; WP_001295163.1; NZ_WPGW01000003.1.
DR   AlphaFoldDB; P0AC01; -.
DR   SMR; P0AC01; -.
DR   STRING; 198214.SF3390; -.
DR   EnsemblBacteria; AAN44852; AAN44852; SF3390.
DR   EnsemblBacteria; AAP19326; AAP19326; S4373.
DR   GeneID; 1026968; -.
DR   KEGG; sfl:SF3390; -.
DR   KEGG; sfx:S4373; -.
DR   PATRIC; fig|198214.7.peg.4003; -.
DR   HOGENOM; CLU_012520_3_0_6; -.
DR   OrthoDB; 1046291at2; -.
DR   UniPathway; UPA00784; UER00770.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR   CDD; cd05009; SIS_GlmS_GlmD_2; 1.
DR   InterPro; IPR035490; GlmS/FrlB_SIS.
DR   InterPro; IPR001347; SIS_dom.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   Pfam; PF01380; SIS; 1.
DR   SUPFAM; SSF53697; SSF53697; 1.
DR   PROSITE; PS51464; SIS; 2.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome; Repeat.
FT   CHAIN           1..340
FT                   /note="Fructoselysine 6-phosphate deglycase"
FT                   /id="PRO_0000136595"
FT   DOMAIN          35..169
FT                   /note="SIS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00797"
FT   DOMAIN          201..331
FT                   /note="SIS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00797"
SQ   SEQUENCE   340 AA;  38569 MW;  503497DD301942C6 CRC64;
     MLDIDKSTVD FLVTENMVQE VEKVLSHDVP LVHAIVEEMV KRDIDRIYFV ACGSPLNAAQ
     TAKHLADRFS DLQVYAISGW EFCDNTPYRL DDRCAVIGVS DYGKTEEVIK ALELGRACGA
     LTAAFTKRAD SPITSAAEFS IDYQADCIWE IHLLLCYSVV LEMITRLAPN AEIGKIKNDL
     KQLPNALGHL VRTWEEKGRQ LGELASQWPM IYTVAAGPLR PLGYKEGIVT LMEFTWTHGC
     VIESGEFRHG PLEIVEPGVP FLFLLGNDES RHTTERAINF VKQRTDNVIV IDYAEISQGL
     HPWLAPFLMF VPMEWLCYYL SIYKDHNPDE RRYYGGLVEY