ID   ALDH9_POLMI             Reviewed;         228 AA.
AC   Q94688;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Aldehyde dehydrogenase 9;
DE            EC=1.2.1.3;
DE   AltName: Full=PM-ALDH9;
DE   Flags: Fragment;
GN   Name=ALDH9;
OS   Polyandrocarpa misakiensis (Tunicate).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Styelidae; Polyandrocarpa.
OX   NCBI_TaxID=7723;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Ushimado;
RA   Harafuji N., Miyashita S., Kawamura K., Fujiwara S.;
RT   "Molecular cloning and expression of aldehyde dehydrogenases in the budding
RT   ascidian Polyandrocarpa misakiensis.";
RL   Mem. Fac. Sci. Kochi Univ. D Biol. 16:7-16(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.3;
CC   -!- PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol:
CC       step 2/2.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; D88309; BAA13586.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q94688; -.
DR   SMR; Q94688; -.
DR   UniPathway; UPA00780; UER00768.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006068; P:ethanol catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN           <1..>228
FT                   /note="Aldehyde dehydrogenase 9"
FT                   /id="PRO_0000056431"
FT   ACT_SITE        99
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        132
FT                   /evidence="ECO:0000255"
FT   BINDING         76..81
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT   NON_TER         228
SQ   SEQUENCE   228 AA;  24460 MW;  8EF9C3084AB1CB88 CRC64;
     FPLLMQAWKL GPALACGNTV VMKTAEQTPL TALYVAALAK EAGFPPGVIN IISGYGPTAG
     AAISEHMDVD KVAFTGSTET AHIVMEAAAK SNLKRVSLEL GGKSPMIVLA DSDLDFAVDT
     CHHGLFFNMG QCCCAGSRIY VQEGVYDEFV KKSVERAKKR TVGDPFTEGI EQGPQIDTEQ
     FNKINRMIEE GKQSGAKLLC GGKRWGDKGY YIEPTVFSDV PDDSTIGS