FRLR_ECO57
ID FRLR_ECO57 Reviewed; 243 AA.
AC Q8X835;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 24-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Probable fructoselysine utilization operon transcriptional repressor {ECO:0000250|UniProtKB:P45544};
DE AltName: Full=HTH-type transcriptional regulator FrlR {ECO:0000250|UniProtKB:P45544};
GN Name=frlR; OrderedLocusNames=Z4736, ECs4225;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: May regulate the transcription of the frlABCDR operon,
CC involved in the utilization of fructoselysine and psicoselysine.
CC {ECO:0000250|UniProtKB:P45544}.
CC -!- PATHWAY: Carbohydrate metabolism; fructoselysine degradation
CC [regulation]. {ECO:0000250|UniProtKB:P45544}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG58483.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB37648.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE005174; AAG58483.1; ALT_INIT; Genomic_DNA.
DR EMBL; BA000007; BAB37648.1; ALT_INIT; Genomic_DNA.
DR PIR; A91157; A91157.
DR PIR; G86002; G86002.
DR RefSeq; NP_312252.4; NC_002695.1.
DR RefSeq; WP_001302327.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; Q8X835; -.
DR SMR; Q8X835; -.
DR STRING; 155864.EDL933_4581; -.
DR EnsemblBacteria; AAG58483; AAG58483; Z4736.
DR EnsemblBacteria; BAB37648; BAB37648; ECs_4225.
DR GeneID; 915920; -.
DR KEGG; ece:Z4736; -.
DR KEGG; ecs:ECs_4225; -.
DR PATRIC; fig|386585.9.peg.4411; -.
DR eggNOG; COG2188; Bacteria.
DR HOGENOM; CLU_063236_8_2_6; -.
DR OMA; RYKLWVP; -.
DR UniPathway; UPA00784; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.1410.10; -; 1.
DR InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR011663; UTRA.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00392; GntR; 1.
DR Pfam; PF07702; UTRA; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SMART; SM00866; UTRA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF64288; SSF64288; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..243
FT /note="Probable fructoselysine utilization operon
FT transcriptional repressor"
FT /id="PRO_0000050643"
FT DOMAIN 10..78
FT /note="HTH gntR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT DNA_BIND 38..57
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ SEQUENCE 243 AA; 27835 MW; 973FF621388AA266 CRC64;
MSATDRYSHQ LLYATVRQRL LDDIAQGVYQ AGQQIPTENE LCTQYNVSRI TIRKAISDLV
ADGVLIRWQG KGTFVQSQKV ENALLTVSGF TDFGVSQGKA TKEKVIEQER ISAAPFCEKL
NIPGNSEVFH LCRVMYLDKE PLFIDSSWIP LSRYPDFDEI YVEGSSTYQL FQERFDTRVV
SDKKTIDIFA ATRPQAKWLK CELGEPLFRI SKIAFDQNDK PVHVSELFCR ANRITLTIDN
KRH
