FRLR_SHIFL
ID FRLR_SHIFL Reviewed; 243 AA.
AC Q83PX4;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 24-OCT-2003, sequence version 2.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Probable fructoselysine utilization operon transcriptional repressor {ECO:0000250|UniProtKB:P45544};
DE AltName: Full=HTH-type transcriptional regulator FrlR {ECO:0000250|UniProtKB:P45544};
GN Name=frlR; OrderedLocusNames=SF3393, S4369;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: May regulate the transcription of the frlABCDR operon,
CC involved in the utilization of fructoselysine and psicoselysine.
CC {ECO:0000250|UniProtKB:P45544}.
CC -!- PATHWAY: Carbohydrate metabolism; fructoselysine degradation
CC [regulation]. {ECO:0000250|UniProtKB:P45544}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN44855.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAP19323.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE005674; AAN44855.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE014073; AAP19323.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_709148.1; NC_004337.2.
DR RefSeq; WP_005052755.1; NZ_WPGW01000003.1.
DR AlphaFoldDB; Q83PX4; -.
DR SMR; Q83PX4; -.
DR STRING; 198214.SF3393; -.
DR EnsemblBacteria; AAN44855; AAN44855; SF3393.
DR EnsemblBacteria; AAP19323; AAP19323; S4369.
DR GeneID; 1026530; -.
DR KEGG; sfl:SF3393; -.
DR KEGG; sft:NCTC1_03674; -.
DR KEGG; sfx:S4369; -.
DR PATRIC; fig|198214.7.peg.4006; -.
DR HOGENOM; CLU_063236_8_2_6; -.
DR OrthoDB; 1775418at2; -.
DR UniPathway; UPA00784; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.1410.10; -; 1.
DR InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR011663; UTRA.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00392; GntR; 1.
DR Pfam; PF07702; UTRA; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SMART; SM00866; UTRA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF64288; SSF64288; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..243
FT /note="Probable fructoselysine utilization operon
FT transcriptional repressor"
FT /id="PRO_0000050644"
FT DOMAIN 10..78
FT /note="HTH gntR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT DNA_BIND 38..57
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ SEQUENCE 243 AA; 27837 MW; 37F3EF6232A7B11E CRC64;
MSATDRYSHQ LLYATVRQRL LDDIAQGVYQ AGQQIPTENE LCTQYNVSRI TIRKAISDLV
ADGVLIRWQG KGTFVQSQKV ENALLTVSGF TDFGVSQGKS TKEKVIEQER VSAAPFCEKL
NIPGNSEVFH LCRVMYLDKE PLFIDSSWIP LSRYPDFDEI YVEGSSTYQL FQERFDTRVV
SDKKTIDIFA ATRPQAKWLK CELGEPLFRI SKIAFDQNDK PVHVSELFCR ANRITLTIDN
KRH
