FRMC_DICDI
ID FRMC_DICDI Reviewed; 1489 AA.
AC P0CD60;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 09-FEB-2010, sequence version 1.
DT 25-MAY-2022, entry version 40.
DE RecName: Full=FERM domain-containing protein C;
GN Name=frmC; ORFNames=DDB_G0289313;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
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DR EMBL; AAFI02000137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAFI02000138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0CD60; -.
DR SMR; P0CD60; -.
DR dictyBase; DDB_G0289313; frmC.
DR InParanoid; P0CD60; -.
DR OMA; HTINIQY; -.
DR PRO; PR:P0CD60; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR CDD; cd14473; FERM_B-lobe; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SUPFAM; SSF47031; SSF47031; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Coiled coil; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..1489
FT /note="FERM domain-containing protein C"
FT /id="PRO_0000391333"
FT DOMAIN 637..934
FT /note="FERM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT REPEAT 1017..1040
FT /note="LRR 1"
FT REPEAT 1053..1075
FT /note="LRR 2"
FT REPEAT 1087..1110
FT /note="LRR 3"
FT REPEAT 1111..1133
FT /note="LRR 4"
FT REPEAT 1167..1191
FT /note="LRR 5"
FT REPEAT 1196..1219
FT /note="LRR 6"
FT REPEAT 1254..1278
FT /note="LRR 7"
FT REPEAT 1282..1306
FT /note="LRR 8"
FT REPEAT 1339..1362
FT /note="LRR 9"
FT REPEAT 1367..1391
FT /note="LRR 10"
FT REPEAT 1395..1418
FT /note="LRR 11"
FT REPEAT 1428..1450
FT /note="LRR 12"
FT REPEAT 1451..1474
FT /note="LRR 13"
FT REGION 59..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 103..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 202..289
FT /evidence="ECO:0000255"
FT COILED 356..383
FT /evidence="ECO:0000255"
FT COMPBIAS 62..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1489 AA; 166978 MW; 291FE09885010CD7 CRC64;
MEGVEDDLSK LLEELSSGVV LNNIQEKLNQ SSPKLQSFID DETGSNAEDV RRVLDAATDT
ESNYGGGANS ITNTPNFNSH RGHQHLQLHT ELSLDALRPV SENSPLHKSA TRPISTSIRL
PRLSVCEDDS SSSSSSSDGD SNSSSDSSDN SSEQSDDDDV HLHLHLHRHH RKVKEDEGDS
FESSSESSEQ YGSPSTLRRQ EALKLEKIMQ IQEKKKLLKE KLKEQDELEL KEKQELNEIT
VQKEIKLKDK SNSVQNDIVD SDNNNNNNNN NSITIEEQQQ EKQQQQQQHH HHHSTPNKPP
KSRSVSISTP DSNIVVAGGN VISKERKRSI LASFEEGSPM RSSSRLPSSR GGSIKIKVSK
VLEEEMQLQQ EFEKQEQLRH SARLSQLIRD LNMSSNLQDQ QDQQLRKNEN SNNNEGDDNN
ENVSNDNSSD NENQNINGSI LIKEEQQEKI EITTTITTVI TPPPPAQEPQ HQQQPKILTP
EEVEEERIRV LRIERMKDQV FSQLDELEDP LYSNGSRQRN GGGGGASTSA EPSMMQIPLT
RLEDTASSSS SPTLQATKTT TTTTTTTTTT TTATLPINNK NLNIQGRPRK DSISDHWDIG
RKEQPRRSMT LNIQRVGEDF SVKKAEAKKV NPDLEKILVH ISLVDQSHKV ICITEDFTVK
DVIDLFSEKL GLVQTEFFSL AEVTSDGYDR WLDPNRAVKE AGIKNLSKLT FKIKYFKQPK
KLSDSKAVHL YYLQIQQSVV NGTYPCSEAM SYRLSALQFY ITFGAFDKDK HIAGFLDHGS
LSEFIPSNFF FELTDEVIQK RLFHLHSQIK CSSSIEAKLR YLDLANKIPT FGVTSFQVFD
GIRESSIVRQ KRHLCVAEDG ILISRKDRAG YDFFSYKEII SYQVTTRGLK IQIPHSSITP
NTSETMSFDT SSYDQSNNII DLMMGYKYFI QHDEFIRGIG APVEQVDLNI SLLLPLFQPP
KIRTKSDPLR SRLELFKLNY LGLCQNFHTK PISKLIDQID YILDKEGSFR NRLAFEKVEL
PSLNLRGSDL SFIADALKDT LNLIIEEGES IVENLNILSL DLSNNPLLAT DAFEPLKIIM
TCNTIIHLNL KNIGLSNKGV MPLVTIIEKY PNIETLQIGK NRVNESGVRV ILRAIKNFNV
KIETLGFEET NLTDSGCLII DKLLSNNKTI KNLNISKNLI TEEGFHHIFE GIKRNSLSLQ
DLNISGNKIN SKLMIKFIKW LASSETSIIT LNIAKTGLES SFGAELQKFL VGNSCHIKSL
DTSYNDLGTS GTKNVIKGII NNQTITELSL CANKISSSGC NDLCQSLELA SATCSKLYLR
HCGLGSSSLV RIANMLELNK TITTLDLSMN EFSKSSSSAI GTMLEKNETL QEFYLADSSL
GAREVESILN GLKNNSTIKK IFLDTNPIGK KGISSLANML NTNTGLEVIT LRHTNLNGKD
ILELLKQLST NIPIKIINLT ENTLDKITPQ IKNAINDQIK RLHTINIQY
