FRMD3_HUMAN
ID FRMD3_HUMAN Reviewed; 597 AA.
AC A2A2Y4; A8MQB0; B4DN14; Q53EP2; Q5JV59; Q5VZA1; Q86WP8; Q8IZ44; Q8N3Y5;
AC Q8N9L2;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=FERM domain-containing protein 3;
DE AltName: Full=Band 4.1-like protein 4O;
DE AltName: Full=Ovary type protein 4.1;
DE Short=4.1O;
GN Name=FRMD3; Synonyms=EPB41L4O;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Fetal brain;
RX PubMed=12601556; DOI=10.1007/s100380300015;
RA Ni X., Ji C., Cao G., Cheng H., Guo L., Gu S., Ying K., Zhao R.C., Mao Y.;
RT "Molecular cloning and characterization of the protein 4.1O gene, a novel
RT member of the protein 4.1 family with focal expression in ovary.";
RL J. Hum. Genet. 48:101-106(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 34-597 (ISOFORM 2).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-597 (ISOFORM 1).
RC TISSUE=Kidney;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP FUNCTION.
RX PubMed=17260017; DOI=10.1038/sj.onc.1210225;
RA Haase D., Meister M., Muley T., Hess J., Teurich S., Schnabel P.,
RA Hartenstein B., Angel P.;
RT "FRMD3, a novel putative tumour suppressor in NSCLC.";
RL Oncogene 26:4464-4468(2007).
CC -!- FUNCTION: Putative tumor suppressor gene that may be implicated in the
CC origin and progression of lung cancer. {ECO:0000269|PubMed:17260017}.
CC -!- INTERACTION:
CC A2A2Y4; Q96FZ5: CMTM7; NbExp=3; IntAct=EBI-6911547, EBI-2807956;
CC A2A2Y4; O43169: CYB5B; NbExp=3; IntAct=EBI-6911547, EBI-1058710;
CC A2A2Y4; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-6911547, EBI-10266796;
CC A2A2Y4; Q8IXM6: NRM; NbExp=3; IntAct=EBI-6911547, EBI-10262547;
CC A2A2Y4; Q5VZY2: PLPP4; NbExp=3; IntAct=EBI-6911547, EBI-10485931;
CC A2A2Y4; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-6911547, EBI-10329948;
CC A2A2Y4; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-6911547, EBI-749270;
CC A2A2Y4; Q96G79: SLC35A4; NbExp=3; IntAct=EBI-6911547, EBI-12363689;
CC A2A2Y4; Q5SNT2-2: TMEM201; NbExp=3; IntAct=EBI-6911547, EBI-11994282;
CC A2A2Y4; A2RU14: TMEM218; NbExp=3; IntAct=EBI-6911547, EBI-10173151;
CC A2A2Y4; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-6911547, EBI-12111910;
CC A2A2Y4; O95159: ZFPL1; NbExp=3; IntAct=EBI-6911547, EBI-718439;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=A2A2Y4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2A2Y4-2; Sequence=VSP_031167;
CC Name=3;
CC IsoId=A2A2Y4-3; Sequence=VSP_031163, VSP_031165, VSP_031167;
CC Name=4;
CC IsoId=A2A2Y4-4; Sequence=VSP_031162, VSP_031166, VSP_031167;
CC Name=5;
CC IsoId=A2A2Y4-5; Sequence=VSP_031164;
CC -!- TISSUE SPECIFICITY: Ovary-specific. {ECO:0000269|PubMed:12601556}.
CC -!- DEVELOPMENTAL STAGE: Expressed in skeletal muscle, lower levels in
CC thymus and brain. {ECO:0000269|PubMed:12601556}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04321.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=EAW62650.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY137774; AAN52119.1; -; mRNA.
DR EMBL; AK094281; BAC04321.1; ALT_INIT; mRNA.
DR EMBL; AK297722; BAG60076.1; -; mRNA.
DR EMBL; EF560742; ABQ59052.1; -; mRNA.
DR EMBL; AL161786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL137847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL450026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471089; EAW62647.1; -; Genomic_DNA.
DR EMBL; CH471089; EAW62649.1; -; Genomic_DNA.
DR EMBL; CH471089; EAW62650.1; ALT_INIT; Genomic_DNA.
DR EMBL; CH471089; EAW62651.1; -; Genomic_DNA.
DR EMBL; BC023560; AAH23560.1; -; mRNA.
DR EMBL; BC037253; AAH37253.1; -; mRNA.
DR EMBL; AK223597; BAD97317.1; -; mRNA.
DR CCDS; CCDS43840.1; -. [A2A2Y4-1]
DR CCDS; CCDS59131.1; -. [A2A2Y4-4]
DR CCDS; CCDS59132.1; -. [A2A2Y4-3]
DR CCDS; CCDS59133.1; -. [A2A2Y4-2]
DR CCDS; CCDS75852.1; -. [A2A2Y4-5]
DR RefSeq; NP_001231888.1; NM_001244959.1. [A2A2Y4-2]
DR RefSeq; NP_001231889.1; NM_001244960.1. [A2A2Y4-5]
DR RefSeq; NP_001231890.1; NM_001244961.1. [A2A2Y4-3]
DR RefSeq; NP_001231891.1; NM_001244962.1. [A2A2Y4-4]
DR RefSeq; NP_777598.3; NM_174938.5. [A2A2Y4-1]
DR AlphaFoldDB; A2A2Y4; -.
DR SMR; A2A2Y4; -.
DR BioGRID; 129190; 24.
DR IntAct; A2A2Y4; 24.
DR STRING; 9606.ENSP00000303508; -.
DR iPTMnet; A2A2Y4; -.
DR PhosphoSitePlus; A2A2Y4; -.
DR BioMuta; FRMD3; -.
DR jPOST; A2A2Y4; -.
DR MassIVE; A2A2Y4; -.
DR MaxQB; A2A2Y4; -.
DR PaxDb; A2A2Y4; -.
DR PeptideAtlas; A2A2Y4; -.
DR PRIDE; A2A2Y4; -.
DR ProteomicsDB; 234; -. [A2A2Y4-1]
DR ProteomicsDB; 235; -. [A2A2Y4-2]
DR ProteomicsDB; 236; -. [A2A2Y4-3]
DR ProteomicsDB; 237; -. [A2A2Y4-4]
DR ProteomicsDB; 238; -. [A2A2Y4-5]
DR Antibodypedia; 27519; 135 antibodies from 21 providers.
DR DNASU; 257019; -.
DR Ensembl; ENST00000304195.8; ENSP00000303508.3; ENSG00000172159.16. [A2A2Y4-1]
DR Ensembl; ENST00000328788.5; ENSP00000328615.1; ENSG00000172159.16. [A2A2Y4-4]
DR Ensembl; ENST00000376434.5; ENSP00000365617.1; ENSG00000172159.16. [A2A2Y4-3]
DR Ensembl; ENST00000376438.5; ENSP00000365621.1; ENSG00000172159.16. [A2A2Y4-2]
DR Ensembl; ENST00000621208.4; ENSP00000484839.1; ENSG00000172159.16. [A2A2Y4-5]
DR GeneID; 257019; -.
DR KEGG; hsa:257019; -.
DR MANE-Select; ENST00000304195.8; ENSP00000303508.3; NM_174938.6; NP_777598.3.
DR UCSC; uc004amq.1; human. [A2A2Y4-1]
DR CTD; 257019; -.
DR DisGeNET; 257019; -.
DR GeneCards; FRMD3; -.
DR HGNC; HGNC:24125; FRMD3.
DR HPA; ENSG00000172159; Tissue enhanced (heart muscle, skeletal muscle, tongue).
DR MIM; 607619; gene.
DR neXtProt; NX_A2A2Y4; -.
DR OpenTargets; ENSG00000172159; -.
DR PharmGKB; PA134903920; -.
DR VEuPathDB; HostDB:ENSG00000172159; -.
DR eggNOG; KOG3530; Eukaryota.
DR GeneTree; ENSGT00940000158577; -.
DR HOGENOM; CLU_113149_0_0_1; -.
DR InParanoid; A2A2Y4; -.
DR OMA; CPLRQWM; -.
DR OrthoDB; 484046at2759; -.
DR PhylomeDB; A2A2Y4; -.
DR TreeFam; TF343477; -.
DR PathwayCommons; A2A2Y4; -.
DR SignaLink; A2A2Y4; -.
DR BioGRID-ORCS; 257019; 12 hits in 1071 CRISPR screens.
DR ChiTaRS; FRMD3; human.
DR GenomeRNAi; 257019; -.
DR Pharos; A2A2Y4; Tbio.
DR PRO; PR:A2A2Y4; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; A2A2Y4; protein.
DR Bgee; ENSG00000172159; Expressed in secondary oocyte and 192 other tissues.
DR ExpressionAtlas; A2A2Y4; baseline and differential.
DR Genevisible; A2A2Y4; HS.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central.
DR CDD; cd14473; FERM_B-lobe; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FERM-adjacent.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF47031; SSF47031; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..597
FT /note="FERM domain-containing protein 3"
FT /id="PRO_0000318098"
FT TRANSMEM 531..551
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 32..312
FT /note="FERM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT REGION 383..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..344
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031162"
FT VAR_SEQ 1..194
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031163"
FT VAR_SEQ 1..49
FT /note="MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQ ->
FT MQLSK (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:12601556"
FT /id="VSP_031164"
FT VAR_SEQ 195..198
FT /note="KNEL -> MVFR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031165"
FT VAR_SEQ 345..398
FT /note="SSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPSPSEQEEELPL
FT GE -> MQAEETKGIGITSMAKCLVKIQTRRSLQLHMVNHCNSNVFVRLLRLGSKVTAR
FT NT (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031166"
FT VAR_SEQ 553..597
FT /note="GIDLSFLCEIRQTPEFEQFHYEYYCPLKEWVAGKVHLILYMLGCS -> VSM
FT Q (in isoform 2, isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_031167"
FT VARIANT 485
FT /note="D -> Y (in dbSNP:rs4877747)"
FT /id="VAR_048366"
FT CONFLICT 248
FT /note="Q -> R (in Ref. 1; AAN52119)"
FT /evidence="ECO:0000305"
FT CONFLICT 554
FT /note="I -> V (in Ref. 1; AAN52119)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 597 AA; 68772 MW; 0B11ABBDDDE0AE67 CRC64;
MFASCHCVPR GRRTMKMIHF RSSSVKSLSQ EMRCTIRLLD DSEISCHIQR ETKGQFLIDH
ICNYYSLLEK DYFGIRYVDP EKQRHWLEPN KSIFKQMKTH PPYTMCFRVK FYPHEPLKIK
EELTRYLLYL QIKRDIFHGR LLCSFSDAAY LGACIVQAEL GDYDPDEHPE NYISEFEIFP
KQSQKLERKI VEIHKNELRG QSPPVAEFNL LLKAHTLETY GVDPHPCKDS TGTTTFLGFT
AAGFVVFQGN KRIHLIKWPD VCKLKFEGKT FYVIGTQKEK KAMLAFHTST PAACKHLWKC
GVENQAFYKY AKSSQIKTVS SSKIFFKGSR FRYSGKVAKE VVEASSKIQR EPPEVHRANI
TQSRSSHSLN KQLIINMEPL QPLLPSPSEQ EEELPLGEGV PLPKEENISA PLISSSPVKA
AREYEDPPSE EEDKIKEEPL TISELVYNPS ASLLPTPVDD DEIDMLFDCP SRLELEREDT
DSFEDLEADE NAFLIAEEEE LKEARRALSW SYDILTGHIR VNPLVKSFSR LLVVGLGLLL
FVFPLLLLLL ESGIDLSFLC EIRQTPEFEQ FHYEYYCPLK EWVAGKVHLI LYMLGCS
